ChemicalBook > CAS DataBase List > D-P-METHYL SULFONE PHENYL ETHYL SERINATE

D-P-METHYL SULFONE PHENYL ETHYL SERINATE

Product Name
D-P-METHYL SULFONE PHENYL ETHYL SERINATE
CAS No.
36983-12-7
Chemical Name
D-P-METHYL SULFONE PHENYL ETHYL SERINATE
Synonyms
D-p-Methyl;Florfenicol Impurity 10;Acetildenafil Impurity 3;D-p-Methyl-sulfino phenyl ethyl;D- p-sulfoxylphenylserine ethyl;D-(4-Methylsulfonyl)phenylserineester;D-P-METHYL SULFONE PHENYL ETHYL SERITE;Ethyl D-4-(methylsulfinophenyl)serinate;D-P-METHYL SULFONE PHENYL ETHYL SERINATE;D-p-methyI sulfone phenyl ethyl serinate
CBNumber
CB1674479
Molecular Formula
C12H17NO5S
Formula Weight
287.33
MOL File
36983-12-7.mol
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D-P-METHYL SULFONE PHENYL ETHYL SERINATE Property

Melting point:
135-137°C
Boiling point:
515.0±50.0 °C(Predicted)
Density 
1.309
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform
form 
Solid
pka
10.57±0.45(Predicted)
color 
White
optical activity
1.00°(C=0.01g/mL, MEOH, 589nm)
InChI
InChI=1/C12H17NO5S/c1-3-18-12(15)10(13)11(14)8-4-6-9(7-5-8)19(2,16)17/h4-7,10-11,14H,3,13H2,1-2H3/t10-,11+/s3
InChIKey
CEEHCOWSYFANRT-WQVXQJEGNA-N
SMILES
[C@@H](C1C=CC(S(=O)(=O)C)=CC=1)(O)[C@@H](N)C(=O)OCC |&1:0,12,r|
CAS DataBase Reference
36983-12-7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M326190
Product name
D-p-MethylSulfonePhenylEthylSerinate
Packaging
10g
Price
$1085
Updated
2021/12/16
AK Scientific
Product number
A515
Product name
D-p-Methylsulfonephenylethylserinate
Packaging
1g
Price
$21
Updated
2021/12/16
Activate Scientific
Product number
AS49130
Product name
D-P-Methyl sulfino phenyl ethyl serinate
Purity
95% ee
Packaging
1g
Price
$32
Updated
2021/12/16
Activate Scientific
Product number
AS49130
Product name
D-P-Methyl sulfino phenyl ethyl serinate
Purity
95% ee
Packaging
5G
Price
$82
Updated
2021/12/16
Activate Scientific
Product number
AS49130
Product name
D-P-Methyl sulfino phenyl ethyl serinate
Purity
95% ee
Packaging
25g
Price
$232
Updated
2021/12/16
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D-P-METHYL SULFONE PHENYL ETHYL SERINATE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Florfenicol intermediate.

Synthesis

5398-77-6

623-33-6

31925-27-6

GENERAL STEPS: 500 g (15.6 mol) of methanol was added to a 1000 ml three-necked flask. Under stirring conditions, 73.9 g (0.53 mol) of ethyl glycinate hydrochloride was added and the temperature was slowly raised to 50-55°C until the ethyl glycinate hydrochloride was completely dissolved. Subsequently, 67.5 g (0.27 mol) of copper sulfate pentahydrate was added to this solution and stirring was continued until complete dissolution and stirring was maintained at 50-55°C for 0.5 hr. Next, triethylamine was added dropwise to the reaction system and the pH was adjusted to 8.5-9.0. Then, 92 g (0.5 mol) of p-methylsulfonylbenzaldehyde was added, and the reaction temperature was maintained at 50-55 °C and the pH was maintained between 8.5-9.0 by adding triethylamine. During the reaction, the progress of the reaction was monitored by HPLC, and the reaction was judged to be complete when the percentage of peak area of p-methylsulfonylbenzaldehyde was less than 2%. At the end of the reaction, methanol was recovered by decompression distillation, and the temperature inside the reaction flask was controlled to be no more than 50 °C during the distillation process. After the recovery of methanol, 600 g of water was added to the reaction flask, and after sufficient stirring, 146.7 g of ethyl 3-(p-toluenesulfonylphenyl)serinate was obtained by centrifugation, with a moisture content of 10.0%, a purity of 97.2% and a yield of 92%.

References

[1] Patent: CN108373430, 2018, A. Location in patent: Paragraph 0017; 0040; 0045-0059

D-P-METHYL SULFONE PHENYL ETHYL SERINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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D-P-METHYL SULFONE PHENYL ETHYL SERINATE Suppliers

Canada 1 China 191 India 4 United States 8 Global 204
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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HBCChem, Inc.
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View Lastest Price from D-P-METHYL SULFONE PHENYL ETHYL SERINATE manufacturers

airuikechemical co., ltd.
Product
D-threo-beta-Methylsulfonylphenylserine ethyl ester 36983-12-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-07
Hebei Chuanghai Biotechnology Co,.LTD
Product
D-P-Methyl Sulfone Phenyl Ethyl Serinate 36983-12-7
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
D-p-Methyl Sulfone Phenyl Ethyl Serinate 36983-12-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

36983-12-7, D-P-METHYL SULFONE PHENYL ETHYL SERINATERelated Search:

Thiamphenicol DL-Glutamine D(-)-Asparagine monohydrate D(-)-Glutamic acid D-Methionine D-(-)-Asparagine monohydrate (+)-Dibenzoyl-D-tartaric acid (1S,2S)-(+)-2-AMINO-3-METHOXY-1-PHENYL-1-PROPANOL D-P-METHYL SULFONE PHENYL ETHYL SERINATE (1S,2S)-(+)-2-AMINO-1-[4-(METHYLTHIO)PHENYL]-1,3-PROPANEDIOL (S)-3-Fluoro-pyrrolidine hydrochloride (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol METHYL (R)-3-HYDROXY-3-PHENYLPROPANOATE DL-THREO-3-PHENYLSERINE BETA-HYDROXY-4-(METHYLSULFONYL)-PHENYLALANINE ETHYL ESTER (2R,3S)-3-PHENYLSERINE (+)-ETHYL (R)-3-HYDROXY-3-PHENYLPROPIONATE

  • D-P-METHYL SULFONE PHENYL ETHYL SERINATE
  • Cuprum D-4-Methylsulfinophenylethylserinate
  • D-p-Methyl
  • D-p-Methyl-sulfino phenyl ethyl
  • D-p-Methyl sulfone phenyl ethyl serinate (d-PSE)
  • (S)--Hydroxy-4-(methylsulfonyl)-D-phenylalanine Ethyl Ester
  • D-threo--Methylsulfonylphenylserine Ethyl Ester
  • (S)-beta-Hydroxy-4-(methylsulfonyl)-D-Phenylalanine ethyl ester
  • D-threo-beta-Methylsulfonylphenylserine ethyl ester
  • (S)-ethyl 3-hydroxy-2-(4-(methylsulfonyl)phenylamino)propanoate
  • REF DUPL: D-4-Methylsulfonylphenyl serine ethyl ester
  • D-Phenylalanine, b-hydroxy-4-(Methylsulfonyl)-,ethyl ester, (bS)-
  • Ethyl D-4-(methylsulfinophenyl)serinate
  • (2R,3S)-Ethyl 2-amino-3-hydroxy-3-(4-(methylsulfonyl)phenyl)propanoate
  • D-P-METHYL SULFONE PHENYL ETHYL SERITE
  • D-Para-Methyl Sulfone Phenyl Ethyl Serinate
  • D- p-sulfoxylphenylserine ethyl
  • D-Phenylalanine, β-hydroxy-4-(methylsulfonyl)-, ethyl ester, (βS)-
  • S)-beta-Hydroxy-4-(methylsulfonyl)-D-Phenylalanine ethyl este
  • D-p-methyI sulfone phenyl ethyl serinate
  • D-p-methylsulfonylphenylserine ethyl ester
  • 1-[(1-Ethoxy-3-hydroxy-1-oxopropan-2-yl)-sulfinoamino]-4-methylbenzene
  • Acetildenafil Impurity 3
  • Florfenicol Impurity 10
  • D-(4-Methylsulfonyl)phenylserineester
  • 36983-12-7
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 36983-12-7