ChemicalBook > CAS DataBase List > 6-NITROQUINAZOLIN-4(3H)-ONE

6-NITROQUINAZOLIN-4(3H)-ONE

Product Name
6-NITROQUINAZOLIN-4(3H)-ONE
CAS No.
6943-17-5
Chemical Name
6-NITROQUINAZOLIN-4(3H)-ONE
Synonyms
NSC 51669;Afatinib Impurity 102;6-NITRO-4-QUINAZOLONE;6-NITROQUINAZOLIN-4-OL;6-Nitro-4-quinazolinol;6-NITROQUIZOLIN-4(3H)-ONE;6-NITRO-4(3H)-QUINAZOLINONE;6-NITROQUINAZOLIN-4(3H)-ONE;6-Nitro-3H-quinazolin-4-one;6-NITRO-4(1H)-QUINAZOLINONE
CBNumber
CB1676877
Molecular Formula
C8H5N3O3
Formula Weight
191.14
MOL File
6943-17-5.mol
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6-NITROQUINAZOLIN-4(3H)-ONE Property

Melting point:
286-287 °C
Boiling point:
407.0±47.0 °C(Predicted)
Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
-1.01±0.20(Predicted)
color 
Yellow
InChI
InChI=1S/C8H5N3O3/c12-8-6-3-5(11(13)14)1-2-7(6)9-4-10-8/h1-4H,(H,9,10,12)
InChIKey
MOBNCKURXDGQCB-UHFFFAOYSA-N
SMILES
N1C2=C(C=C([N+]([O-])=O)C=C2)C(=O)NC=1
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
N596450
Product name
6-Nitro-4-quinazolone
Packaging
500mg
Price
$525
Updated
2021/12/16
TRC
Product number
N596450
Product name
6-Nitro-4-quinazolone
Packaging
1g
Price
$950
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0076033
Product name
6-NITROQUINAZOLIN-4-OL
Purity
95.00%
Packaging
1G
Price
$1686.3
Updated
2021/12/16
AK Scientific
Product number
V7338
Product name
6-Nitroquinazolin-4(3H)-one
Packaging
100g
Price
$1882
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0076033
Product name
6-NITROQUINAZOLIN-4-OL
Purity
95.00%
Packaging
100MG
Price
$716.1
Updated
2021/12/16
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6-NITROQUINAZOLIN-4(3H)-ONE Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Intermediate in the preparation of anticancer agents and enzyme inhibitors.

Synthesis

77287-34-4

616-79-5

6943-17-5

1. Preparation of 6-nitro-3H-quinazolin-4-one: 150 g of 2-amino-5-nitrobenzoic acid was added to 200 ml of formamide and stirred until completely dissolved. The reaction mixture was heated to 170°C and maintained at this temperature for 4 hours. After completion of the reaction, the mixture was cooled to 100°C. 500 ml of ice water was slowly added and stirring was continued for 1 hour. Subsequently, the mixture was filtered under reduced pressure and the solid product was collected. The solid was washed with plenty of water to remove residual reactants and by-products. Finally, the resulting solid was dried at 40 °C for 15 h to afford 4-hydroxy-6-nitroquinazoline (140 g, 90% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 300 MHz): δ8.77 (d, J = 2.7 Hz, 1H), 8.55 (dd, J = 6.9 Hz, 1H), 8.36 (s, 1H), 7.84 (d, J = 9 Hz, 1H).

References

[1] Patent: WO2006/71017, 2006, A1. Location in patent: Page/Page column 34
[2] Tetrahedron Letters, 2002, vol. 43, # 21, p. 3911 - 3913
[3] Tetrahedron Letters, 2003, vol. 44, # 24, p. 4455 - 4458
[4] Patent: US2005/187231, 2005, A1. Location in patent: Page/Page column 14
[5] Tetrahedron, 2013, vol. 69, # 15, p. 3182 - 3191

6-NITROQUINAZOLIN-4(3H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-NITROQUINAZOLIN-4(3H)-ONE Suppliers

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View Lastest Price from 6-NITROQUINAZOLIN-4(3H)-ONE manufacturers

Career Henan Chemical Co
Product
6-NITROQUINAZOLIN-4(3H)-ONE 6943-17-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

6943-17-5, 6-NITROQUINAZOLIN-4(3H)-ONERelated Search:

6-NITROQUINAZOLIN-4(3H)-ONE 7-Fluoro-6-nitro-4-hydroxyquinazoline 2,4-DIHYDROXY-6-NITROQUINAZOLINE 6-Nitro-7-Chloro-4-HydroxyQuinazoline 2-AMINO-6-NITRO-4(3H)-QUINAZOLONE 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE 7-FLUORO-6-NITROQUINAZOLIN-4(3H)-ONE 2-mercapto-7-nitroquinazolin-4(3H)-one 3-ethyl-2-mercapto-7-nitroquinazolin-4(3H)-one 2-[4-Methyl-1-piperazinyl]-6-nitroquinazolin-4(3H)-one 2-[4-Methyl-1-piperazinyl]-7-nitroquinazolin-4(3H)-one 2-Methyl-6-nitroquinazolin-4(3H)-one 3-ethyl-2-mercapto-6-nitroquinazolin-4(3H)-one 7-MORPHOLIN-4-YL-6-NITROQUINAZOLIN-4(3H)-ONE 2-mercapto-6-nitroquinazolin-4(3H)-one 7-(METHYLAMINO)-6-NITROQUINAZOLIN-4(3H)-ONE 7-CHLORO-6-NITROQUINAZOLIN-4(3H)-ONE 2-mercapto-3-methyl-6-nitroquinazolin-4(3H)-one

  • 6-NITRO-4(1H)-QUINAZOLINONE
  • 6-nitro-1,4-dihydroquinazolin-4-one
  • Afatinib Impurity 102
  • 6-NITRO-4(3H)-QUINAZOLINONE
  • 6-NITRO-4-QUINAZOLONE
  • 6-NITROQUINAZOLIN-4(3H)-ONE
  • 6-NITROQUINAZOLIN-4-OL
  • 6-nitro-3,4-dihydroquinazolin-4-one
  • 6-Nitro-3H-quinazolin-4-one
  • NSC 51669
  • 4-hydroxy-6-nitroquinazoline
  • 6-Nitro-4-hydroxyquinazoline
  • 6-NITROQUIZOLIN-4(3H)-ONE
  • 6-nitro-1H-quinazolin-4-one
  • 6-nitroquinazolin-4(1H)-one
  • 4(3H)-Quinazolinone, 6-nitro-
  • 6-nitro-2,3-dihydroquinazolin-4(1H)-one
  • 6-Nitro-4-quinazolinol
  • 6943-17-5
  • C8H5N3O3
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