DICLOFENAC-D4
- Product Name
- DICLOFENAC-D4
- CAS No.
- 153466-65-0
- Chemical Name
- DICLOFENAC-D4
- Synonyms
- D4-Diclofenac;DICLOFENAC-D4;[2H4]-Diclofenac;Diclofenac-D4 (Major);DICLOFENAC-D4 (PHENYL-D4);2-((2,6-Dichlorophenyl)aminobenzeneacetic Acid-d4,;Diclofenac D4 acid (phenyl D4) 100 μg/mL in Acetone;2-[2,3,4,5-tetradeuterio-6-(2,6-dichloroanilino)phenyl]aceticaci;2-[2,3,4,5-tetradeuterio-6-(2,6-dichloroanilino)phenyl]acetic acid;Diclofenac D4Q: What is Diclofenac D4 Q: What is the CAS Number of Diclofenac D4 Q: What is the storage condition of Diclofenac D4 Q: What are the applications of Diclofenac D4
- CBNumber
- CB1677920
- Molecular Formula
- C14H11Cl2NO2
- Formula Weight
- 296.15
- MOL File
- 153466-65-0.mol
DICLOFENAC-D4 Property
- Melting point:
- 157-159°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml
- form
- A solid
- color
- White to off-white
- Water Solubility
- Water: 50 mg/ml
- CAS DataBase Reference
- 153466-65-0
N-Bromosuccinimide Price
- Product number
- 19072
- Product name
- Diclofenac-d4
- Purity
- ≥99%
- Packaging
- 500μg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- 19072
- Product name
- Diclofenac-d4
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- D436452
- Product name
- Diclofenac-d4
- Packaging
- 1mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- D436452
- Product name
- Diclofenac-d4
- Packaging
- 10mg
- Price
- $825
- Updated
- 2021/12/16
- Product number
- FD165151
- Product name
- Diclofenac-D4
- Packaging
- 250ug
- Price
- $60
- Updated
- 2021/12/16
DICLOFENAC-D4 Chemical Properties,Usage,Production
Description
Diclofenac-d4 is intended for use as an internal standard for the quantification of diclofenac (Item Nos. 70680 | 22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Chemical Properties
Off-White Crystalline Solid
Uses
Labeled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. 92% overall isotopic purity. A representative lot was 75% d4, 23% d3 and 2 % d2
Uses
Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
Uses
Labelled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
References
[1] O LANEUVILLE. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 2: 927-934.
[2] SHABBIR LOBO. Evaluation of diclofenac prodrugs for enhancing transdermal delivery.[J]. Drug Development and Industrial Pharmacy, 2014, 40 3: 425-432. DOI: 10.3109/03639045.2013.767828
[3] JEAN LEANDRO DOS SANTOS. Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.[J]. International Journal of Molecular Sciences, 2012, 13 11: 15305-15320. DOI: 10.3390/ijms131115305
[4] HIMANSHU V. KOTHARI Edmond C K Warren H Lee. An alternate mechanism for regulation of leukotriene production in leukocytes: studies with an anti-inflammatory drug, sodium diclofenac[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987, 921 3: Pages 502-511. DOI: 10.1016/0005-2760(87)90078-6
[5] PRIYANKA ARORA Biswajit M. Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt[J]. Journal of pharmaceutical sciences, 2002, 91 9: 2076-2089. DOI: 10.1002/jps.10200
DICLOFENAC-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
DICLOFENAC-D4 Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 020-81960175
- Fax
- +1-541-2553641
- min.he@cato-chem.com
- Country
- China
- ProdList
- 1955
- Advantage
- 55
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9906
- Advantage
- 50
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0755-0755-28967200-8062 13631290199
- Fax
- 0755-28967200
- wxf@sungening.com
- Country
- China
- ProdList
- 9624
- Advantage
- 60
- Tel
- 025-84622273 17361806303
- kexin.zhou@haolvbiotech.com
- Country
- China
- ProdList
- 3019
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58