Description References
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Diclofenac potassium

Description References
Product Name
Diclofenac potassium
CAS No.
15307-81-0
Chemical Name
Diclofenac potassium
Synonyms
Keflan;ProSorb;K-fenak;Cataflam;Voltfast;CGP-45840B;Unii-L4D5ua6cb4;PotassiuM diclofenac;Diclofenic potassiuM;DICLOFENAC POTASSIUM
CBNumber
CB9348932
Molecular Formula
C14H10Cl2KNO2
Formula Weight
334.24
MOL File
15307-81-0.mol
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Diclofenac potassium Property

Melting point:
300-330 °C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.
form 
neat
CAS DataBase Reference
15307-81-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-51/53
Safety Statements 
61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2922492050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1039990
Product name
Diclofenac potassium
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
d1039990
Price
$190
Updated
2020/08/18
Sigma-Aldrich
Product number
D1039990
Product name
Diclofenac potassium
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
PHR2441
Product name
Diclofenac potassium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$229
Updated
2021/03/22
Sigma-Aldrich
Product number
1188709
Product name
Diclofenac potassium
Packaging
200mg
Price
$366
Updated
2021/03/22
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Diclofenac potassium Chemical Properties,Usage,Production

Description

Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.

References

Brogden, R. N., et al. "Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin." Drugs 20.1 (1980): 24-48.
Gan, Tong J. "Diclofenac: an update on its mechanism of action and safety profile." Current medical research and opinion 26.7 (2010): 1715-1731.
Riihiluoma, P., E. Wuolijoki, and M. O. Pulkkinen. "Treatment of primary dysmenorrhea with diclofenac sodium." European Journal of Obstetrics & Gynecology and Reproductive Biology 12.3 (1981): 189-194.

Chemical Properties

White or slightly yellowish, slightly hygroscopic, crystalline powder.

Uses

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.

Definition

ChEBI: The potassium salt of diclofenac.

brand name

Cataflam (Novartis).

Diclofenac potassium Preparation Products And Raw materials

Raw materials

Preparation Products

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Diclofenac potassium Suppliers

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd.
Tel
027-83850122-
Email
918571372@qq.com
Country
China
ProdList
986
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
Email
721846333@qq.com
Country
China
ProdList
630
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18227
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15424
Advantage
60
China Langchem Inc.
Tel
0086-21-58956006;021-38701807;021-58950017
Fax
0086-21-58956100
Country
China
ProdList
7833
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
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View Lastest Price from Diclofenac potassium manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Diclofenac potassium 15307-81-0
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-09
Wuhan Aoliqisi New Material Technology Co., Ltd.
Product
Diclofenac potassium 15307-81-0
Price
US $1.00/g
Min. Order
1000g
Purity
99%
Supply Ability
20ton/month
Release date
2021-07-13
Wuhan wingroup Pharmaceutical Co., Ltd
Product
Diclofenac potassium 15307-81-0
Price
US $10.00/KG
Min. Order
100g
Purity
99%
Supply Ability
2000MT/Month
Release date
2021-07-02

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