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Diclofenac potassium

Description References
Product Name
Diclofenac potassium
CAS No.
15307-81-0
Chemical Name
Diclofenac potassium
Synonyms
PotassiuM diclofenac;Cataflam;Keflan;ProSorb;K-fenak;Voltfast;CGP-45840B;Unii-L4D5ua6cb4;Diclofenac potassiu;Diclofenic potassiuM
CBNumber
CB9348932
Molecular Formula
C14H10Cl2KNO2
Formula Weight
334.24
MOL File
15307-81-0.mol
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Diclofenac potassium Property

Melting point:
300-330 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.
form 
Solid
color 
White to off-white
CAS DataBase Reference
15307-81-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-51/53
Safety Statements 
61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2922492050
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2441
Product name
Diclofenac potassium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$280
Updated
2024/03/01
Sigma-Aldrich
Product number
D1039990
Product name
Diclofenac potassium
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
d1039990
Price
$91.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1188709
Product name
Diclofenac potassium
Packaging
200mg
Price
$786
Updated
2024/03/01
Usbiological
Product number
273151
Product name
Diclofenac potassium
Packaging
1g
Price
$375
Updated
2021/12/16
TRC
Product number
D436460
Product name
DiclofenacPotassiumSalt
Packaging
250mg
Price
$230
Updated
2021/12/16
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Diclofenac potassium Chemical Properties,Usage,Production

Description

Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.

References

Brogden, R. N., et al. "Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin." Drugs 20.1 (1980): 24-48.
Gan, Tong J. "Diclofenac: an update on its mechanism of action and safety profile." Current medical research and opinion 26.7 (2010): 1715-1731.
Riihiluoma, P., E. Wuolijoki, and M. O. Pulkkinen. "Treatment of primary dysmenorrhea with diclofenac sodium." European Journal of Obstetrics & Gynecology and Reproductive Biology 12.3 (1981): 189-194.

Chemical Properties

White or slightly yellowish, slightly hygroscopic, crystalline powder.

Uses

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.

Application

Diclofenac Potassium Salt is a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.

Definition

ChEBI: The potassium salt of diclofenac.

brand name

Cataflam (Novartis).

Diclofenac potassium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Diclofenac potassium manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Diclofenac Potassium 15307-81-0
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Diclofenac potassium 15307-81-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%-101% USP
Supply Ability
1000KGS
Release date
2021-07-21
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Diclofenac potassium 15307-81-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1tons
Release date
2024-04-26

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