Diclofenac potassium
Description References- Product Name
- Diclofenac potassium
- CAS No.
- 15307-81-0
- Chemical Name
- Diclofenac potassium
- Synonyms
- PotassiuM diclofenac;Cataflam;Keflan;ProSorb;K-fenak;Voltfast;CGP-45840B;Unii-L4D5ua6cb4;Diclofenac potassiu;Diclofenic potassiuM
- CBNumber
- CB9348932
- Molecular Formula
- C14H10Cl2KNO2
- Formula Weight
- 334.24
- MOL File
- 15307-81-0.mol
Diclofenac potassium Property
- Melting point:
- 300-330 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.
- form
- Solid
- color
- White to off-white
- CAS DataBase Reference
- 15307-81-0(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- PHR2441
- Product name
- Diclofenac potassium
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500MG
- Price
- $280
- Updated
- 2024/03/01
- Product number
- D1039990
- Product name
- Diclofenac potassium
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- d1039990
- Price
- $91.8
- Updated
- 2024/03/01
- Product number
- 1188709
- Product name
- Diclofenac potassium
- Packaging
- 200mg
- Price
- $786
- Updated
- 2024/03/01
- Product number
- 273151
- Product name
- Diclofenac potassium
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- D436460
- Product name
- DiclofenacPotassiumSalt
- Packaging
- 250mg
- Price
- $230
- Updated
- 2021/12/16
Diclofenac potassium Chemical Properties,Usage,Production
Description
Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.
References
Brogden, R. N., et al. "Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin." Drugs 20.1 (1980): 24-48.
Gan, Tong J. "Diclofenac: an update on its mechanism of action and safety profile." Current medical research and opinion 26.7 (2010): 1715-1731.
Riihiluoma, P., E. Wuolijoki, and M. O. Pulkkinen. "Treatment of primary dysmenorrhea with diclofenac sodium." European Journal of Obstetrics & Gynecology and Reproductive Biology 12.3 (1981): 189-194.
Chemical Properties
White or slightly yellowish, slightly hygroscopic, crystalline powder.
Uses
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.
Application
Diclofenac Potassium Salt is a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.
Definition
ChEBI: The potassium salt of diclofenac.
brand name
Cataflam (Novartis).
Diclofenac potassium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diclofenac potassium manufacturers
- Product
- Diclofenac Potassium 15307-81-0
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-24
- Product
- Diclofenac potassium 15307-81-0
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%-101% USP
- Supply Ability
- 1000KGS
- Release date
- 2021-07-21
- Product
- Diclofenac potassium 15307-81-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1tons
- Release date
- 2024-04-26