ChemicalBook > CAS DataBase List > (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

Product Name: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL
CAS No.: 18881-17-9
Chemical Name: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL
Synonyms: Tic-ol;in-3-yL;)-methanoL;(S)-Tetrahydroisoquinolinyl-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL;(S)-1,2,3,4-tetrahydroisoquinolne-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL;(3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol;(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol;3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
CBNumber: CB1690134
Molecular Formula: C10H13NO
Formula Weight: 163.22
MOL File: 18881-17-9.mol

Less

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Property

Melting point:: 114-116 °C(lit.)
Boiling point:: 290.31°C (rough estimate)
Density: 1.0508 (rough estimate)
refractive index: -97 ° (C=0.2, MeOH)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.57±0.10(Predicted)
form: Crystalline Powder and/or Chunks
color: Off-white
optical activity: [α]22/D 97°, c = 1 in methanol
CAS DataBase Reference: 18881-17-9(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 494186
Product name: (S)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol
Purity: 98%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: T1755
Product name: (S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $102
Updated: 2023/01/07

AK Scientific

Product number: X3151
Product name: (S)-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol
Packaging: 5g
Price: $107
Updated: 2021/12/16

Ark Pharm

Product number: P000190192
Product name: (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
Purity: 97%
Packaging: 10g
Price: $128
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK222185
Product name: (3S)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol
Purity: 98%
Packaging: 250mg
Price: $48
Updated: 2021/12/16

Less

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Synthesis

79815-19-3

18881-17-9

GENERAL STEPS: The experimental manipulation of this reaction was improved by referring to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether:ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline as a yellow crystalline solid (yield: 2.09 g, 98% yield, melting point 95-97 °C). The specific optical rotation of the product was in agreement with that reported in literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0 , 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Suppliers

Belgium 1 China 116 Germany 4 India 2 Japan 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 23 Global 159

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16077
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Litong Chemical Technology Co.,Ltd.

Tel: 13598610367 0373-7129549
Fax: 0373-8369699
Email: 2468833170@qq.com
Country: China
ProdList: 932
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shijiazhuang Lickon PharmaTech Co., Ltd.

Tel: 031185291771 13832391721
Fax: 0311-67305698
Email: yaofeng2005@163.com
Country: China
ProdList: 978
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9986
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Shanghai Chuangtuo BioTechnology Co., Ltd.

Tel: 021-64301660 18121244935
Fax: 021-64301660
Email: sales@chuangtuobio.com
Country: China
ProdList: 94
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Civic Chemical Technology Co., Ltd.

Tel: 021-34053660
Fax: QQ:2881074831
Email: sale2@labgogo.com
Country: China
ProdList: 2018
Advantage: 58

Wuxi KaideRui Pharmaceutical Technology Co., Ltd

Tel: 19906241957
Fax: -
Email: 1557216087@qq.com
Country: China
ProdList: 1837
Advantage: 55

Greenherbs Science and Technology Development Co., Ltd.

Tel: 010-61136123
Fax: +86 (10) 8857-9127
Email: pub02@greenherbs.com.cn
Country: China
ProdList: 4049
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Haimen DsHare Pharmaceutical Technology Co., Ltd.

Tel: +86-0513-68050135 13962878782
Fax: 0513-68050130
Email: zhuwdsh@126.com
Country: China
ProdList: 158
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Nanjing NingFan Pharm-Tech CO. LTD.

Tel: 17368696818
Country: China
ProdList: 1984
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Suzhou East Polaris Chemical Co., Ltd.

Tel: 0512-66873333 18516099287
Fax: 0512-66873333
Email: sudamaster@163.com
Country: CHINA
ProdList: 116
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Yurlic Chemical S&T Co.Ltd.

Tel: 021-37285141 15618858630
Fax: 021-37285142
Email: yancf@yulibiotech.com
Country: China
ProdList: 170
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Less

View Lastest Price from (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 18881-17-9
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Career Henan Chemical Co

Product: (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 18881-17-9
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

18881-17-9, (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOLRelated Search:

D-7-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (3S)-2-CARBOBENZOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID L-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid H-TIC-OH N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid FMOC-TIC-OH BOC-7-HYDROXY-TIC-OH 1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL 5,6,7,8-TETRAHYDROISOQUINOLINE 1,2,3,4-TETRAHYDROISOQUINOLINE (S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL,(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Z-D-TIC-OH (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID T-BUTYL ESTER BOC-D-TIC-OH H-D-TIC-OTBU HCL

(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline

(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline97%

(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol

(3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol

(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol,99%e.e.

3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

(S)-3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

(S)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL-METHANOL

(S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL

(S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL

(S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97%

(S)-1,2,3,4-tetrahydroisoquinolne-3-methanol

(S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE-METHANOL 98%

(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylmethanol

(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97%

S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL(S)-()-1,2

3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3S)-

in-3-yL

)-methanoL

(S)-Tetrahydroisoquinolinyl-3-methanol

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL USP/EP/BP

Tic-ol

(<i>S</i>)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol

18881-17-9

C10H13NO

Chiral Building Blocks

Asymmetric Synthesis

Heterocyclic Building Blocks

Isoquinolines

chiral

Chiral Building Blocks

Heterocyclic Building Blocks

Isoquinolines