1,2,3,4-Tetrahydroisoquinoline-3-methanol
- Product Name
- 1,2,3,4-Tetrahydroisoquinoline-3-methanol
- CAS No.
- 63006-93-9
- Chemical Name
- 1,2,3,4-Tetrahydroisoquinoline-3-methanol
- Synonyms
- AKOS BB-8834;1,2,3,4-Tetrahydro-3-isoquinolinemethano;1,2,3,4-tetrahydro-3-isoquinolineMethanol;1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL;3-IsoquinolineMethanol,1,2,3,4-tetrahydro-;3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
- CBNumber
- CB5421897
- Molecular Formula
- C10H13NO
- Formula Weight
- 163.22
- MOL File
- 63006-93-9.mol
1,2,3,4-Tetrahydroisoquinoline-3-methanol Property
- Melting point:
- 180-182?C
- Boiling point:
- 83-85 °C(Press: 0.3 Torr)
- Density
- 1.081±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- soluble in Dichloromethane
- form
- Crystalline
- pka
- 14.57±0.10(Predicted)
- Appearance
- light yellow solid
- Water Solubility
- Soluble in dichloromethane. Slightly soluble in water.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T293785
- Product name
- rac1,2,3,4-Tetrahydroisoquinoline-3-methanol
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- T293785
- Product name
- rac1,2,3,4-Tetrahydroisoquinoline-3-methanol
- Packaging
- 5g
- Price
- $1035
- Updated
- 2021/12/16
- Product number
- 9556AB
- Product name
- (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
- Packaging
- 25g
- Price
- $1508
- Updated
- 2021/12/16
- Product number
- CHM0023630
- Product name
- 3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2044.35
- Updated
- 2021/12/16
- Product number
- 9556AB
- Product name
- (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
- Packaging
- 5g
- Price
- $496
- Updated
- 2021/12/16
1,2,3,4-Tetrahydroisoquinoline-3-methanol Chemical Properties,Usage,Production
Chemical Properties
Light Orange Solid
Uses
rac 1,2,3,4-Tetrahydroisoquinoline-3-methanol (cas# 63006-93-9) is a compound useful in organic synthesis.
Synthesis
79815-19-3
18881-17-9
GENERAL STEPS: The synthesis was modified with reference to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the reaction progress was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether: ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (4) as a yellow crystalline solid in a yield of 2.09 g (98% yield, melting point 95-97 °C). The specific optical rotation of the product was in agreement with that reported in the literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0 , 47.83, 30.9.
References
[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414
1,2,3,4-Tetrahydroisoquinoline-3-methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,2,3,4-Tetrahydroisoquinoline-3-methanol manufacturers
- Product
- 1,2,3,4-Tetrahydroisoquinoline-3-methanol 63006-93-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02