(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

Product Name: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL
CAS No.: 18881-17-9
Chemical Name: (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL
Synonyms: Tic-ol;in-3-yL;)-methanoL;(S)-Tetrahydroisoquinolinyl-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL;(S)-1,2,3,4-tetrahydroisoquinolne-3-methanol;(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL;(3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol;(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol;3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE
CBNumber: CB1690134
Molecular Formula: C10H13NO
Formula Weight: 163.22
MOL File: 18881-17-9.mol

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(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Property

Melting point:: 114-116 °C(lit.)
Boiling point:: 290.31°C (rough estimate)
Density: 1.0508 (rough estimate)
refractive index: -97 ° (C=0.2, MeOH)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 14.57±0.10(Predicted)
form: Crystalline Powder and/or Chunks
color: Off-white
optical activity: [α]22/D 97°, c = 1 in methanol
CAS DataBase Reference: 18881-17-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 494186
Product name: (S)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol
Purity: 98%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: T1755
Product name: (S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $102
Updated: 2023/01/07

AK Scientific

Product number: X3151
Product name: (S)-(-)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol
Packaging: 5g
Price: $107
Updated: 2021/12/16

Ark Pharm

Product number: P000190192
Product name: (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol
Purity: 97%
Packaging: 10g
Price: $128
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK222185
Product name: (3S)-1,2,3,4-Tetrahydroisoquinolin-3-ylmethanol
Purity: 98%
Packaging: 250mg
Price: $48
Updated: 2021/12/16

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(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Synthesis

79815-19-3

18881-17-9

GENERAL STEPS: The experimental manipulation of this reaction was improved by referring to the literature [6]. LiAlH4 (1.98 g, 52.0 mmol) was suspended in anhydrous THF (100 mL) under nitrogen protection, stirred and cooled to 0 °C. Subsequently, a THF solution of methyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (2.50 g, 13.0 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 3 h at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent being petroleum ether:ethyl acetate (70:30, Rf = 0.43). Upon completion of the reaction, saturated sodium sulfate solution (4 mL) and THF (20 mL) were slowly added to quench the excess LiAlH4 at 0 °C. The inorganic solids were removed by filtration, and the filter cake was washed with ethyl acetate (3 × 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline as a yellow crystalline solid (yield: 2.09 g, 98% yield, melting point 95-97 °C). The specific optical rotation of the product was in agreement with that reported in literature [6].1H NMR (400 MHz, CDCl3) δ: 2.57 (dd, 1H, J = 10.8, 11.2 Hz), 2.70 (dd, 1H, J = 4.34, 16.42 Hz), 3.05-3.10 (m, 1H), 3.49 (dd, 1H, J = 8.17, 10.82 Hz), 3.78 (dd, 1H, J = 3.98, 10.60 Hz), 4.05 (s, 2H), 7.01-7.15 (m, 4H).13C NMR (100 MHz, CDCl3) δ: 135.6, 133.9, 129.3, 126.3, 126.0, 125.9, 65.8, 55.0 , 47.83, 30.9.

References

[1] South African Journal of Chemistry, 2010, vol. 63, p. 195 - 198
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 407 - 414

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Suppliers

Belgium 1 China 116 Germany 4 India 2 Japan 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 23 Global 159

J & K SCIENTIFIC LTD.

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Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 18881-17-9
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Career Henan Chemical Co

Product: (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 18881-17-9
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

18881-17-9, (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOLRelated Search:

D-7-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID (3S)-2-CARBOBENZOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID L-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid H-TIC-OH N-Fmoc-D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid FMOC-TIC-OH BOC-7-HYDROXY-TIC-OH 1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL 5,6,7,8-TETRAHYDROISOQUINOLINE 1,2,3,4-TETRAHYDROISOQUINOLINE (S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL,(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL Z-D-TIC-OH (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (S)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID T-BUTYL ESTER BOC-D-TIC-OH H-D-TIC-OTBU HCL

(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline

(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline97%

(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol

(3S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol

(S)-1,2,3,4-Tetrahydro-3-isoquinolinylmethanol,99%e.e.

3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

(S)-3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

(S)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL-METHANOL

(S)-(-)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL

(S)-1,2,3,4-TETRAHYDROISOQUINOLYLMETHAN-3-OL

(S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL

(S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97%

(S)-1,2,3,4-tetrahydroisoquinolne-3-methanol

(S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE-METHANOL 98%

(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylmethanol

(3S)-3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline 97%

S)-(-)-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINEMETHANOL(S)-()-1,2

3-Isoquinolinemethanol, 1,2,3,4-tetrahydro-, (3S)-

in-3-yL

)-methanoL

(S)-Tetrahydroisoquinolinyl-3-methanol

(S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL USP/EP/BP

Tic-ol

(<i>S</i>)-(?)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol

18881-17-9

C10H13NO

Chiral Building Blocks

Asymmetric Synthesis

Heterocyclic Building Blocks

Isoquinolines

chiral

Chiral Building Blocks

Heterocyclic Building Blocks

Isoquinolines