ChemicalBook > CAS DataBase List > 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE

Product Name
2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
CAS No.
6622-92-0
Chemical Name
2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
Synonyms
4-Hydroxy-2,6-dimethyL;2,6-DIMETHYL-4-PYRIMIDINO;2,6-dimethlpyrimidin-4-ol;6-dimethyl pyrimidin-4-ol;2,6-DIMETHYLPYRIMIDIN-4-OL;2,6-DIMETHYL-4-PYRIMIDINOL;2,4-Dimethyl-6-pyrimidinol;2,4-Dimethylpyrimidine-6-ol;2,6-Dimethylpyrimidine-4-ol;2,6-dimethylpyrimidine-4--one
CBNumber
CB1692244
Molecular Formula
C6H8N2O
Formula Weight
124.14
MOL File
6622-92-0.mol
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2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Property

Melting point:
198.5-200 °C (lit.)
Boiling point:
230.92°C (rough estimate)
Density 
1.1683 (rough estimate)
refractive index 
1.5378 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
form 
Crystalline Needles
pka
9.87±0.50(Predicted)
color 
White
BRN 
114324
InChI
InChI=1S/C6H8N2O/c1-4-3-6(9)8-5(2)7-4/h3H,1-2H3,(H,7,8,9)
InChIKey
UQFHLJKWYIJISA-UHFFFAOYSA-N
SMILES
C1(C)=NC(C)=CC(=O)N1
CAS DataBase Reference
6622-92-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D2579
Product name
2,4-Dimethyl-6-hydroxypyrimidine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$97
Updated
2025/07/31
TCI Chemical
Product number
D2579
Product name
2,4-Dimethyl-6-hydroxypyrimidine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$317
Updated
2025/07/31
TRC
Product number
D480258
Product name
2,6-Dimethyl-1H-pyrimidin-4-one
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
D480258
Product name
2,6-Dimethyl-1H-pyrimidin-4-one
Packaging
10g
Price
$75
Updated
2021/12/16
Oakwood
Product number
222325
Product name
2,6-Dimethylpyrimidin-4-ol
Purity
99%
Packaging
1g
Price
$9
Updated
2021/12/16
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2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Chemical Properties,Usage,Production

Chemical Properties

white crystalline needles

Synthesis

124-42-5

141-97-9

6622-92-0

General procedure for the synthesis of 2,4-dimethyl-6-hydroxypyrimidines from acetamidine hydrochloride and ethyl acetoacetate: to a solution of sodium ethanolate (10.5 g, 154 mmol) in ethanol (200 mL) was added ethyl 3-oxobutanoate (10.0 g, 77 mmol) and acetamidine hydrochloride (7.23 g, 77 mmol) sequentially. The reaction mixture was heated to reflux for 20 hours. After completion of the reaction, water (10 mL) was added to the mixture. The reaction mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (silica gel as stationary phase, dichloromethane/methanol=15:1 as mobile phase) to afford 2,6-dimethylpyrimidin-4-ol as a yellow solid (3.43 g, 36% yield).LRMS (M+H+) m/z: Calculated value 124.06; measured value 124.

References

[1] Patent: WO2013/75083, 2013, A1. Location in patent: Paragraph 00374; 00375
[2] Synthesis (Germany), 2016, vol. 48, # 23, p. 4246 - 4252
[3] Patent: US2012/95031, 2012, A1. Location in patent: Page/Page column 159-160

2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Suppliers

Americas 1 Belgium 1 China 148 Europe 2 Germany 2 India 10 Japan 4 Slovakia 1 Switzerland 1 The Netherlands 4 United Kingdom 12 United States 27 Global 213
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE manufacturers

Dideu Industries Group Limited
Product
2,4-DIMETHYL-6-HYDROXYPYRIMIDINE 6622-92-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-09
Career Henan Chemical Co
Product
2,4-DIMETHYL-6-HYDROXYPYRIMIDINE 6622-92-0
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-23

6622-92-0, 2,4-DIMETHYL-6-HYDROXYPYRIMIDINERelated Search:

N-NONANE 6-(Chloromethyl)-2-phenylpyrimidin-4-ol 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE Diazinon 4,6-Dimethyl-2-hydroxypyrimidine 5-Pyrimidinol, 4,6-dimethyl- (6CI,9CI) 4,6-DIMETHYL-2-HYDROXYPYRIMIDINE HYDROCHLORIDE 97+%,4,6-DIMETHYL-2-HYDROXYPYRIMIDINE HYDROCHLORIDE 4,5-Dimethyl-2-pyrimidinol 2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE 2-(TERT-BUTYL)-6-(CHLOROMETHYL)PYRIMIDIN-4-OL 2-(4-PYRIDYL)-4-HYDROXY-6-MENTHYL PYRIMIDINE 5-CHLORO-6-METHYL-2-(2-PYRIDYL)PYRIMIDIN-4-OL 4-HYDROXY-6-METHOXYMETHYL-2-METHYLPYRIMIDINE 2-methylamino-5,6-dimethyl-4-hydroxypyrimidine 2-Ethylamino-4,5-dimethyl-6-hydroxypyrimidine BUTTPARK 12\02-33 BUTTPARK 74\02-43 O,O-DIETHYL O-(6-METHYL-2-PHENYL-5-[3-(TRIFLUOROMETHYL)PHENOXY]PYRIMIDIN-4-YL) PHOSPHOTHIOATE

  • 6-HYDROXY-2,4-DIMETHYLPYRIMIDINE
  • 4-HYDROXY-2,6-DIMETHYLPYRIMIDINE
  • 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE
  • 2,6-DIMETHYLPYRIMIDIN-4-OL
  • 2,6-DIMETHYL-4-PYRIMIDINO
  • 2,6-DIMETHYL-4-PYRIMIDINOL
  • 2,6-DIMETHYL-4-HYDROXYPYRIMIDINE
  • 2,6-Dimethyl-4(3H)-pyrimidinone
  • 2,6-dimethyl-1,4-dihydropyrimidin-4-one
  • 2,6-Dimethyl-4-pyrimidinol 6-Hydroxy-2,4-dimethylpyrimidine
  • 2,6-DiMethylpyriMidin-4(3H)-One
  • hydroxy-2,6-diMethylpyriMidine
  • 2,4-Dimethyl-6-hydroxypyrimidine, 2,6-Dimethyl-4-pyrimidinol
  • 2,4-Dimethylpyrimidine-6-ol
  • 2,6-Dimethylpyrimidin-4(1H)-one
  • 2,6-Dimethylpyrimidine-4(3H)-one
  • 2,6-Dimethylpyrimidine-4-ol
  • 2,6-Dimethylpyrimidin-4-ol, 2,4-Dimethyl-6-hydroxy-1,3-diazine
  • 2,4-Dimethyl-6-pyrimidinol
  • 6-hydroxy-2,4-dimethylyrimidine
  • 2,6-dimethyl-1H-pyrimidin-4-one
  • 4-Hydroxy-2,6-dimethylpyrimidine, >=99%
  • 4(1H)-Pyrimidinone, 2,6-dimethyl- (8CI,9CI)
  • 2,4-Dimethyl-6-hydroxypyrimidine, 99+%
  • 2,4-Dimethyl-6-hydroxypyrimidine&gt
  • 4-Hydroxy-2,6-dimethyL
  • 4(3H)-Pyrimidinone, 2,6-dimethyl-
  • 2,4-DIMETHYL-6-HYDROXYPYRIMIDINE ISO 9001：2015 REACH
  • 2,6-dimethylpyrimidine-4--one
  • 2,6-Dimethyl-4(1H)-pyrimidinone
  • 2,6-dimethlpyrimidin-4-ol
  • 6-dimethyl pyrimidin-4-ol
  • 6622-92-0
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • alcohol
  • PYRIMIDINE
  • APIs & Intermediate