3,5-DICHLOROISONICOTINIC ACID
- Product Name
- 3,5-DICHLOROISONICOTINIC ACID
- CAS No.
- 13958-93-5
- Chemical Name
- 3,5-DICHLOROISONICOTINIC ACID
- Synonyms
- RARECHEM AL BE 0919;TIMTEC-BB SBB003624;3,5-Dichloroisonicotinic;dichloroisonicotinicacid;3,5-DICHLOROISONICOTINIC ACID;3,5-Dichloroisonicotinicd acid;3,5-DichloroisonicotinicAcid>3,5-DICHLOROISONICOTINIC ACID 98+%;3,5-DICHLORO-4-PYRIDINECARBOXYLIC ACID;3,5-DICHLOROPYRIDINE-4-CARBOXYLIC ACID
- CBNumber
- CB1699405
- Molecular Formula
- C6H3Cl2NO2
- Formula Weight
- 192
- MOL File
- 13958-93-5.mol
3,5-DICHLOROISONICOTINIC ACID Property
- Melting point:
- 230 °C (dec.)(lit.)
- Boiling point:
- 383.0±37.0 °C(Predicted)
- Density
- 1.612±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -1.16±0.25(Predicted)
- color
- White to Almost white
- InChIKey
- BUQPTOSHKHYHHB-UHFFFAOYSA-N
- CAS DataBase Reference
- 13958-93-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 574880
- Product name
- 3,5-Dichloropyridine-4-carboxylic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $89.4
- Updated
- 2023/06/20
- Product number
- D2600
- Product name
- 3,5-Dichloroisonicotinic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- D435010
- Product name
- 3,5-Dichloroisonicotinic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H21-5-35
- Product name
- 3,5-Dichloroisonicotinic acid
- Purity
- 98%
- Packaging
- 5G
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD74887
- Product name
- 3,5-Dichloroisonicotinic acid
- Packaging
- 10g
- Price
- $110
- Updated
- 2021/12/16
3,5-DICHLOROISONICOTINIC ACID Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 32, p. 2178, 1989 DOI: 10.1021/jm00129a026
Synthesis
124-38-9
2457-47-8
13958-93-5
The general procedure for the synthesis of 3,5-dichloropyridine-4-carboxylic acid from carbon dioxide and 3,5-dichloropyridine was as follows: 1. a THF (25 ml) solution of 3,5-dichloropyridine (5.00 g, 33.8 mmol) was slowly added to an LDA solution [prepared from n-butyllithium (2.5 M hexane solution, 14.9 ml, 37.2 mmol) and diisopropylamine (4.10 g, 5.7 ml, 40.6 mmol) in THF (25 ml) at -78°C ] 2. Carbon dioxide gas was bubbled into the reaction system and the solution was observed to change from clear to brown color with gradual formation of precipitate. The reaction mixture was then slowly warmed up to room temperature. 3. After 2 hrs of reaction, the reaction was quenched with water (20 ml) and subsequently partitioned between diethyl ether (100 ml) and 1M NaOH (100 ml). The aqueous layer was separated and acidified to pH 1 with concentrated hydrochloric acid. 4. The acidified aqueous layer was extracted with dichloromethane solution containing 10% methanol. The organic layers were combined and dried with anhydrous magnesium sulfate followed by removal of the solvent under vacuum to give a brown solid. 5. The resulting brown solid was recrystallized from ethanol and dried under vacuum to give finally 3,5-dichloropyridine-4-carboxylic acid as pink crystals (2.63 g, 41% yield). NMR hydrogen spectral data (DMSO-d6): δH 8.72 (2H, s).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 567 - 571
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 709 - 712
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 386 - 390
[4] Patent: US6348463, 2002, B1. Location in patent: Page column 18
[5] Patent: WO2004/6918, 2004, A1. Location in patent: Page/Page column 15
3,5-DICHLOROISONICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-DICHLOROISONICOTINIC ACID manufacturers
- Product
- 3,5-DICHLOROISONICOTINIC ACID 13958-93-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 3,5-DICHLOROISONICOTINIC ACID 13958-93-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 3,5-Dichloropyridine-4-carboxylic acid 13958-93-5
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-12