Michler's ketone

Product Name: Michler's ketone
CAS No.: 90-94-8
Chemical Name: Michler's ketone
Synonyms: Bis(4-(dimethylamino)phenyl)methanone;BIS-DIMETHYLAMINOPHENYLMETHANONE;MICHLERS KETONE;nsc9602;ai3-22412;michler’s;NCI-C02006;Ketone base;MICHLER KETONE;MICHLER'S KETONE
CBNumber: CB1703263
Molecular Formula: C17H20N2O
Formula Weight: 268.35
MOL File: 90-94-8.mol

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Michler's ketone Property

Melting point:: 174 -176 °C(lit.)
Boiling point:: 360 °C
Density: 1.0208 (rough estimate)
refractive index: 1.5486 (estimate)
Flash point:: 220 °C
storage temp.: Store below +30°C.
solubility: ethanol: 5 mg/mL, clear
pka: 2.55±0.12(Predicted)
form: Powder
color: Blue to dark blue or gray
Water Solubility: 400 mg/L (20 ºC)
Merck: 14,6177
BRN: 790733
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents.
InChIKey: VVBLNCFGVYUYGU-UHFFFAOYSA-N
CAS DataBase Reference: 90-94-8(CAS DataBase Reference)
IARC: 2B (Vol. 99) 2010
NIST Chemistry Reference: Methanone, bis[4-(dimethylamino)phenyl]-(90-94-8)
EPA Substance Registry System: Michler's ketone (90-94-8)

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Safety

Hazard Codes: T,Xi
Risk Statements: 45-41-68-36/37/38
Safety Statements: 53-45-36-26
RIDADR: 2811
WGK Germany: 3
RTECS: DJ0250000
Autoignition Temperature: 480 °C
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29223990
Hazardous Substances Data: 90-94-8(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: > 6400 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H341Suspected of causing genetic defects

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.08125
Product name: 4,4′-Bis(dimethylamino)-benzophenone
Purity: for synthesis
Packaging: 250g
Price: $88.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08125
Product name: 4,4′-Bis(dimethylamino)-benzophenone
Purity: for synthesis
Packaging: 1kg
Price: $267
Updated: 2024/03/01

Sigma-Aldrich

Product number: 147834
Product name: Michler’s ketone
Purity: 98%
Packaging: 100g
Price: $54.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 147834
Product name: Michler’s ketone
Purity: 98%
Packaging: 500g
Price: $77.2
Updated: 2024/03/01

TCI Chemical

Product number: B0481
Product name: 4,4'-Bis(dimethylamino)benzophenone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $40
Updated: 2024/03/01

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Michler's ketone Chemical Properties,Usage,Production

Description

Michler's ketone is a blue powder or white togreen-colored leaflet material. Molecular weight = 268.37;Boiling point ≥360℃ (decomposition); Freezing/Meltingpoint= 172-176*C; Flash point = 220-C; Autoignitiontemperature = 480PC. Hazard Identification (based onNFPA-704 M Rating System): Health 3, Flammability 1,Reactivity 0. Insoluble in water.

Chemical Properties

white to light greenish crystals

Chemical Properties

Michler’s ketone is a is a blue powder or white to green-colored leaflet material.

Uses

MK can be used as an additive that acts as a photoinitiator in the preparation of dyes. It can also be used as a precursor material in the synthesis of 4,4′-bis{N,N,dimethyl, N (2-ethoxy carbonyl-1-propenyl) ammonium hexafluoro antimonate}benzophenone (MKEA).

Uses

In manufacture of dyes and pigments.

Definition

ChEBI: 4,4'-Bis(dimethylamino)benzophenone is a member of benzophenones.

Synthesis Reference(s)

Tetrahedron, 38, p. 1163, 1982 DOI: 10.1016/0040-4020(82)85099-0

General Description

White to greenish crystalline leaflets or blue powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4,4'-Bis(dimethylamino)benzophenone is incompatible with strong oxidizing agents and strong reducing agents .

Hazard

Possible carcinogen.

Fire Hazard

Literature sources indicate that 4,4'-Bis(dimethylamino)benzophenone is combustible.

Safety Profile

Confirmed human carcinogen with experimental carcinogenic and neoplastigenic data. A poison by ingestion. Mutation data reported. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Mutagen. Animal Carcinogen. Michler’s ketone is a dye intermediate and derivative of dimethylaniline. It is also used in antifreeze formulations, cosmetics, cleaning compounds; heat transfer fluids; as a chemical intermediate in the synthesis of at least 13 dyes and pigments, especially auramine derivatives.

First aid

Skin Contacr52: Flood all areas of body thathave contacted the substance with water.Do not wait tofemove contaminated clothing; do it under the water stream.Use soapto help assure removal. Isolate contaminatedclothing when removed to prevent contact by others. EyeContact: Remove any contact Tenses at once. Immediatelyflush eyes well with copious quantities of water or normalsaline for at least 20- 30 min. Seek medical attention.Imhalation: Leave contaminated area immediately; breathefresh air. Proper respiratory protection must be supplied toany rescuers. If coughing, difficult breathing. or any othersymptoms develop, seek medical attention at once, even isymptoms develop many hours after exposure. Ingestion: IFunconscious or convulsing, do not induce vomiting or giveanything by mouth. Assure that victim's airway is open andlay him on his side with his head lower than his body andfransport at once to a medical facility. If conscious and noCconvutsing, give a glass of water to dilute the substance. Imedical advice is not readily available, do not inducevomiting, and rush the victim to the nearest medicalfacility.

Carcinogenicity

Michler’s ketone is reasonably anticipated to be a human cagen based on sufficient evidence of carcinogenicity from stud rcinoies in experimental animals.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in a refrigerator or a cool, dry place awayfrom peroxides, aldehydes, strong acids. Where possible,automatically pump liquid from drums or other storage containers to process containers. A regulated, marked areashould be established where this chemical is handled, used,or stored in compliance with OSHA Standard 1910.1045.

Shipping

UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poison Inhalation Hazard. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN1602 Dyes, liquid, toxic, n.o.s or Dye intermediates, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Dissolve the ketone in dilute HCl, filter and precipitate it by adding ammonia (to remove water-insoluble impurities such as benzophenone). Then crystallise it from EtOH or pet ether. [Suppan J Chem Soc, Faraday Trans1 71 539 1975.] It is also purified by dissolving in *benzene, then washing with water until the aqueous phase is colourless. The *benzene is evaporated off, and the residue is recrystallised three times from *benzene and EtOH [Hoshino & Kogure J Phys Chem 72 417 1988]. [Beilstein 14 IV 255.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from aldehydes, alkaline materials, strong acids, strong bases, strong reducing agents such as hydrideds and active metals. Contact with hydrogen peroxide may form heat- and shock- sensitive explosives.

Waste Disposal

Do not discharge into drains or sewers. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. If allowed, Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Michler's ketone Preparation Products And Raw materials

Raw materials

Ethanol N-Methylaniline ETHYLENE OXIDE Formaldehyde Oxygen N,N-Dimethylaniline Chloranil Methanol

Preparation Products

Basic Blue 11 Crystal Violet Basic Blue 26

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Michler's ketone Suppliers

Americas 1 Belgium 3 CHINA 194 Europe 2 France 2 Germany 9 India 9 Japan 4 Switzerland 2 The Netherlands 1 United Kingdom 11 United States 30 Global 268

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View Lastest Price from Michler's ketone manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 4,4'-Bis(dimethylamino)benzophenone 90-94-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-12

Hebei Weibang Biotechnology Co., Ltd

Product: 4,4'-Bis(dimethylamino)benzophenone 90-94-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Mojin Biotechnology Co., Ltd

Product: Michler's ketone 90-94-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-10

90-94-8, Michler's ketoneRelated Search:

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BIS(P-DIMETHYLAMINOPHENYL)KETONE

BIS-DIMETHYLAMINOPHENYLMETHANONE

LABOTEST-BB LT00086928

TETRAMETHYL-P,P'-DIAMINOBENZOPHENONE

MICHLERS KETONE

MICHLER'S KETONE

MICHLER KETONE

P,P'-TETRAMETHYLDIAMINOBENZOPHENONE

N,N,N',N'-TETRAMETHYL-4,4'-DIAMINOBENZOPHENONE

N,N,N,N'-TETRAMETHYL-4,4'-DIAMINOBENZOPHENONE

4,4'-di(Dimethylamino)benzophenone

ai3-22412

Benzophenone, 4,4'-bis(dimethylamino)-

Bis(4-(dimethylamino)phenyl)methanone

bis(dimethylamino)-4,4’benzophenone

bis(p-(n,n-dimethylamino)phenyl)ketone

bis[4-(dimethylamino)phenyl]-methanon

Bis[4-(dimethylamino)phenyl]methanone

bis[4-(dimethylamino)phenyl]-Methanone

Bis[p-(N,N-dimethylamino)phenyl] ketone

Bis-4,4'-(dimethylamino)-benzophenon (michlers keton)

Di-p-dimethylaminophenylketone

Ketone base

michler’s

N,N'-Bisdimethylamino

NCI-C02006

nsc9602

p,p’-bis(dimethylamino)benzophenone

p,p’bis(n,ndimethylamino)benzophenone

p,p’-bis(n,n-dimethylamino)benzophenone

p,p’-michler’sketone

p,p'-bis(Dimethylamino)benzophenone

p,p'-Bis(N,N-dimethylamino)benzophenone

p,p'-Michler's ketone

p,p'-Tetramethyl-4,4'-diaminobenzophenone

tetramethyldiaminobenzophenone

4,4'-BIS(DIMETHYLAMINO)BENZOPHENONE

(Tetramethyldiamino)benzophenone

4,4’-bis(dimethylamino)-benzophenon

4,4’-bis(n,n-dimethylamino)benzophenone

4,4’-Di(N,N-dimethylamino)benzophenone

4,4’-di(N,N-Dimethylamino)diphenylketone

4,4’-Tetramethyldiaminobenzophenone

4,4'-Bis(dimethyL

(2,3-diamino-4,5,6-trimethylphenyl)-(2-methylphenyl)methanone

Michler`s krtone

4,4'-Bis(dimethylamine)benzophenone

Michler'sKetone,98%

N,N'-Tetramethyl-4,4'-diaminobenzophenone

Methanone, bis4-(dimethylamino)phenyl-

BIS(DIMETHYLAMINO)BENZOPHENONE

4,4''-BIS(DIMETHYLAMINO)-BENZOPHENONE 98+%

3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE (4,4''-BIS(DIMETHYLAMINO)BENZOPHENONE)

Bis[4-(dimethylamino)phenyl] ketone

3,6-Dimethyl-1,4-dioxane-2,5-dione (4,4'-Bis(dimethylamino)benzo

Michlers Ketone[4,4-Bis(dimethylamino)benzophenone]

Michler's Ketone N,N,N',N'-Tetramethyl-4,4'-diaminobenzophenone

4,4'-BIS(DIMETHYLAMINO)-BENZOPHENONE FOR