2,2',4,4'-Tetrahydroxybenzophenone

Application Potential Exposure & Risk

Product Name: 2,2',4,4'-Tetrahydroxybenzophenone
CAS No.: 131-55-5
Chemical Name: 2,2',4,4'-Tetrahydroxybenzophenone
Synonyms: BENZOPHENONE-2;TETRAHYDROXYBENZOPHENONE;UV Absorber Benzophenone-2;70A-196;uvinuld-50;Uvinul D-50;Uvinol D-50;Seesorb 106;Sumisorb 150;Sinosorb? BP-2
CBNumber: CB6344256
Molecular Formula: C13H10O5
Formula Weight: 246.22
MOL File: 131-55-5.mol

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2,2',4,4'-Tetrahydroxybenzophenone Property

Melting point:: 198-200 °C(lit.)
Boiling point:: 349.21°C (rough estimate)
Density: 1.216
refractive index: 1.4825 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
form: Solid
pka: 6.98±0.35(Predicted)
color: Needles from H2O
Water Solubility: Slightly soluble in water.
BRN: 1914746
Stability:: Hygroscopic
InChIKey: WXNRYSGJLQFHBR-UHFFFAOYSA-N
LogP: 3.091 (est)
CAS DataBase Reference: 131-55-5(CAS DataBase Reference)
NIST Chemistry Reference: 2,2',4,4'-Tetrahydroxybenzophenone(131-55-5)
EPA Substance Registry System: 2,2',4,4'-Tetrahydroxybenzophenone (131-55-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: DJ1892000
TSCA: Yes
HS Code: 29145090
Hazardous Substances Data: 131-55-5(Hazardous Substances Data)
Toxicity: LD50 oral in rat: 1220mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T16403
Product name: 2,2′,4,4′-Tetrahydroxybenzophenone
Purity: 97%
Packaging: 25g
Price: $62.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: T16403
Product name: 2,2′,4,4′-Tetrahydroxybenzophenone
Purity: 97%
Packaging: 100g
Price: $135
Updated: 2024/03/01

TCI Chemical

Product number: T0118
Product name: 2,2',4,4'-Tetrahydroxybenzophenone
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $39
Updated: 2024/03/01

Alfa Aesar

Product number: A10237
Product name: 2,2',4,4'-Tetrahydroxybenzophenone, 98+%
Packaging: 25g
Price: $39.65
Updated: 2024/03/01

Alfa Aesar

Product number: A10237
Product name: 2,2',4,4'-Tetrahydroxybenzophenone, 98+%
Packaging: 100g
Price: $108.65
Updated: 2024/03/01

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2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties,Usage,Production

Application

2,2',4,4'-Tetrahydroxybenzophenone (BZP-2) is water-soluble and light-yellow powder (figure 1). BZP-2 is widely used in perfumes to prevent their degradation due to light. BZP-2 is a UV-absorber that helps protect against product degradation because of UV-light exposure and it is widely used in sunscreens and in cosmetics (figure 2), such as: anti-aging” creams and hair sprays and shampoos, paints and plastics. It can also mask odor associated with a formulation’s composition. In addition, the hypolipemiant drug fenofibrate is also a substituted benzophenone.

Potential Exposure & Risk

Although 2,2',4,4'-Tetrahydroxybenzophenone is used as a UV-blocker in cosmetics, plastics and automotive car products, its safety issue still should be noted. Such as workers that use BZP-2 may breathe in dust or have direct skin contact and the general population may be exposed by dermal contact with products containing this compound.
Skin allergic reaction has been reported in some people using sunscreens or cosmetics containing this compound. 2,2',4,4'-Tetrahydroxybenzophenone(BZP-2) is a member of a group of chemicals known as endocrine disruptors, which may alter the function and/or development of the reproductive system. Limited evidence indicates that exposure to benzophenone UV-absorbing chemicals, including BZP-2, is associated with an altered ratio of males to females at birth (increased females).

Chemical Properties

yellow to brown crystalline powder

Uses

2,2′,4,4′-Tetrahydroxybenzophenone are benzophenone-type UV filters with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.

Uses

2,2',4,4'-Tetrahydroxybenzophenone is used as the raw material of ultraviolet absorbers in cosmetics, plastics, resins and rubber. It is used as pharmaceutical intermediates and light-sensitive materials. It is also used as pharmaceutical adjuvant.

Uses

2,2',4,4'-Tetrahydroxybenzophenone is a uV-absorber that helps protect against product degradation because of uV-light exposure. It can also mask odor associated with a formulation’s composition.

Preparation

Obtained (small amount) by melting a fluorescin chloride/sodium hydroxide mixture in the presence of a very few water at 230–240° for 2–3 h.

Contact allergens

BZP-2 is widely used in perfumes to prevent their degradation due to light. It can cause allergic contact dermatitis.

Safety Profile

Moderately toxic by ingestion. Aneye irritant. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.

Synthesis

2 mol of resorcinol dimethyl ether is added dropwise to a mixture of 1 mol of phosgene and 1 mol of aluminum chloride, and the mixture is heated to 65-80° C at a temperature of 30-40° C in the presence of a chlorinated hydrocarbon selected from aliphatic and aromatic chlorides, such as ethylene dichloride. It is then cooled to 40° C, 2 to 3 mol of aluminum chloride are added, the mixture is heated to 60-70° C, dilute hydrochloric acid is treated with aqueous sodium hydroxide solution, and 2,2',4,4'-Tetrahydroxybenzophenone is isolated by filtration.

2,2',4,4'-Tetrahydroxybenzophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2',4,4'-Tetrahydroxybenzophenone Suppliers

Belgium 5 Canada 1 China 399 Europe 3 France 1 Germany 11 India 12 Japan 7 Slovakia 1 South Korea 3 Switzerland 3 The Netherlands 3 Ukraine 1 United Kingdom 23 United States 48 USA 1 Global 522

Wuhan Qiaofeng Chemical Technology Co., Ltd.

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Qingdao Truelight functional Materials Technology Co., Ltd.

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Hubei Jusheng Technology Co.,Ltd

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Wuhan EnTai Technology Development Co,.Ltd

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J & K SCIENTIFIC LTD.

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Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.

Tel: 0519-85195575 15861192208
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Meryer (Shanghai) Chemical Technology Co., Ltd.

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INTATRADE GmbH

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View Lastest Price from 2,2',4,4'-Tetrahydroxybenzophenone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,2',4,4'-Tetrahydroxybenzophenone 131-55-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%min
Supply Ability: 500kg/month
Release date: 2021-06-01

Watson Biotechnology Co.,Ltd

Product: Benzophenone-2(BP-2) 131-55-5
Price: US $200.00-130.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-07-27

Jinan Finer Chemical Co., Ltd

Product: 2,2',4,4'-Tetrahydroxybenzophenone 131-55-5
Price: US $5.00/kg
Min. Order: 1kg
Purity: ≥99%
Supply Ability: 500mt/year
Release date: 2022-10-18

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Benzophenone, 2,2'

2,2',4,4'-tetrahyroxybenzophenone

2,2',4,4'-TETRAHYDROXYBENZOPHENONE

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BENZOPHENONE-2

BENZOPHENONE-2-(2,2',4,4'-TETRAHYDROXYBENZOPHENONE)

BIS-(2,4-DIHYDROXY-PHENYL)-METHANONE

2,2',4,4'-Tetrahydroxybenzophenone(bp-2)

TIMTEC-BB SBB003178

2,2',4,4'-Tetrahydroxybenzophe

2.2''-4.4''-TETRAHYD[CL]ROXYBENZOPHENONE

2,2'',4,4''-TETRAHYDROXYBENZOPHENONE 98+%

2,2',4,4'-tetrahydroxy Benzophenone(Benzophenone-2)

Seesorb 106

Sumisorb 150

70A-196

TETRAHYDROXYBENZOPHENONE

2,2',4,4'-Tetrahydroxybenzophenone,97%

4-[(2,4-dihydroxyphenyl)carbonyl]benzene-1,3-diol

2,2',4,4'-Tetrahydroxybenzophenone&gt

UV Absorber Benzophenone-2

2,2’,4,4’-Tetrahydroxybenzophenone Solution in Acetonitrile, 100μg/mL

2,2',4,4'-Tetrahydroxybenzophenone ISO 9001：2015 REACH

UV ABSORBER TRUELICHT BP-2

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2,2',4,4'-Tetrahydroxybenzop

Sinosorb? BP-2

Phloroglucinol Impurity 88

2,2',4,4'-Tetrahydroxybenzophenone

2,2',4,4'-Tetrehydroxybenzophenone

2,2',4,4'-Tetrahydroxybenzophenone(BP-2)

Benzophenone-2(BP-2)

Zolmitriptan Impurity 1-d6

2,2',4,4'-Tetrahydroxybenzophenone in methanol

2,2',4,4'-Tetrehydroxybenzophenone (BP-2)

2,2′,4,4'-Tetrahydroxybenzophenone

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