2,2',4,4'-Tetrahydroxybenzophenone
Application Potential Exposure & Risk- Product Name
- 2,2',4,4'-Tetrahydroxybenzophenone
- CAS No.
- 131-55-5
- Chemical Name
- 2,2',4,4'-Tetrahydroxybenzophenone
- Synonyms
- BENZOPHENONE-2;TETRAHYDROXYBENZOPHENONE;UV Absorber Benzophenone-2;70A-196;uvinuld-50;Uvinul D-50;Uvinol D-50;Seesorb 106;Sumisorb 150;Sinosorb? BP-2
- CBNumber
- CB6344256
- Molecular Formula
- C13H10O5
- Formula Weight
- 246.22
- MOL File
- 131-55-5.mol
2,2',4,4'-Tetrahydroxybenzophenone Property
- Melting point:
- 198-200 °C(lit.)
- Boiling point:
- 349.21°C (rough estimate)
- Density
- 1.216
- refractive index
- 1.4825 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- pka
- 6.98±0.35(Predicted)
- color
- Needles from H2O
- Water Solubility
- Slightly soluble in water.
- BRN
- 1914746
- Stability:
- Hygroscopic
- InChIKey
- WXNRYSGJLQFHBR-UHFFFAOYSA-N
- LogP
- 3.091 (est)
- CAS DataBase Reference
- 131-55-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,2',4,4'-Tetrahydroxybenzophenone(131-55-5)
- EPA Substance Registry System
- 2,2',4,4'-Tetrahydroxybenzophenone (131-55-5)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- DJ1892000
- TSCA
- Yes
- HS Code
- 29145090
- Hazardous Substances Data
- 131-55-5(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 1220mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T16403
- Product name
- 2,2′,4,4′-Tetrahydroxybenzophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $62.4
- Updated
- 2024/03/01
- Product number
- T16403
- Product name
- 2,2′,4,4′-Tetrahydroxybenzophenone
- Purity
- 97%
- Packaging
- 100g
- Price
- $135
- Updated
- 2024/03/01
- Product number
- T0118
- Product name
- 2,2',4,4'-Tetrahydroxybenzophenone
- Purity
- >98.0%(HPLC)
- Packaging
- 25g
- Price
- $39
- Updated
- 2024/03/01
- Product number
- A10237
- Product name
- 2,2',4,4'-Tetrahydroxybenzophenone, 98+%
- Packaging
- 25g
- Price
- $39.65
- Updated
- 2024/03/01
- Product number
- A10237
- Product name
- 2,2',4,4'-Tetrahydroxybenzophenone, 98+%
- Packaging
- 100g
- Price
- $108.65
- Updated
- 2024/03/01
2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties,Usage,Production
Application
2,2',4,4'-Tetrahydroxybenzophenone (BZP-2) is water-soluble and light-yellow powder (figure 1). BZP-2 is widely used in perfumes to prevent their degradation due to light. BZP-2 is a UV-absorber that helps protect against product degradation because of UV-light exposure and it is widely used in sunscreens and in cosmetics (figure 2), such as: anti-aging” creams and hair sprays and shampoos, paints and plastics. It can also mask odor associated with a formulation’s composition. In addition, the hypolipemiant drug fenofibrate is also a substituted benzophenone.
Potential Exposure & Risk
Although 2,2',4,4'-Tetrahydroxybenzophenone is used as a UV-blocker in cosmetics, plastics and automotive car products, its safety issue still should be noted. Such as workers that use BZP-2 may breathe in dust or have direct skin contact and the general population may be exposed by dermal contact with products containing this compound.
Skin allergic reaction has been reported in some people using sunscreens or cosmetics containing this compound. 2,2',4,4'-Tetrahydroxybenzophenone(BZP-2) is a member of a group of chemicals known as endocrine disruptors, which may alter the function and/or development of the reproductive system. Limited evidence indicates that exposure to benzophenone UV-absorbing chemicals, including BZP-2, is associated with an altered ratio of males to females at birth (increased females).
Chemical Properties
yellow to brown crystalline powder
Uses
2,2′,4,4′-Tetrahydroxybenzophenone are benzophenone-type UV filters with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.
Uses
2,2',4,4'-Tetrahydroxybenzophenone is used as the raw material of ultraviolet absorbers in cosmetics, plastics, resins and rubber. It is used as pharmaceutical intermediates and light-sensitive materials. It is also used as pharmaceutical adjuvant.
Uses
2,2',4,4'-Tetrahydroxybenzophenone is a uV-absorber that helps protect against product degradation because of uV-light exposure. It can also mask odor associated with a formulation’s composition.
Preparation
Obtained (small amount) by melting a fluorescin chloride/sodium hydroxide mixture in the presence of a very few water at 230–240° for 2–3 h.
Contact allergens
BZP-2 is widely used in perfumes to prevent their degradation due to light. It can cause allergic contact dermatitis.
Safety Profile
Moderately toxic by ingestion. Aneye irritant. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.
Synthesis
2 mol of resorcinol dimethyl ether is added dropwise to a mixture of 1 mol of phosgene and 1 mol of aluminum chloride, and the mixture is heated to 65-80° C at a temperature of 30-40° C in the presence of a chlorinated hydrocarbon selected from aliphatic and aromatic chlorides, such as ethylene dichloride. It is then cooled to 40° C, 2 to 3 mol of aluminum chloride are added, the mixture is heated to 60-70° C, dilute hydrochloric acid is treated with aqueous sodium hydroxide solution, and 2,2',4,4'-Tetrahydroxybenzophenone is isolated by filtration.
2,2',4,4'-Tetrahydroxybenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2,2',4,4'-Tetrahydroxybenzophenone Suppliers
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View Lastest Price from 2,2',4,4'-Tetrahydroxybenzophenone manufacturers
- Product
- Benzophenone-2 131-55-5
- Price
- US $99.00-35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-14
- Product
- Benzophenone-2(BP-2) 131-55-5
- Price
- US $200.00-130.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2024-07-27
- Product
- 2,2',4,4'-Tetrahydroxybenzophenone 131-55-5
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- ≥99%
- Supply Ability
- 500mt/year
- Release date
- 2022-10-18