Application Potential Exposure & Risk
ChemicalBook > CAS DataBase List > 2,2',4,4'-Tetrahydroxybenzophenone

2,2',4,4'-Tetrahydroxybenzophenone

Application Potential Exposure & Risk
Product Name
2,2',4,4'-Tetrahydroxybenzophenone
CAS No.
131-55-5
Chemical Name
2,2',4,4'-Tetrahydroxybenzophenone
Synonyms
BENZOPHENONE-2;TETRAHYDROXYBENZOPHENONE;UV Absorber Benzophenone-2;70A-196;uvinuld-50;Uvinul D-50;Uvinol D-50;Seesorb 106;Sumisorb 150;Sinosorb? BP-2
CBNumber
CB6344256
Molecular Formula
C13H10O5
Formula Weight
246.22
MOL File
131-55-5.mol
More
Less

2,2',4,4'-Tetrahydroxybenzophenone Property

Melting point:
198-200 °C(lit.)
Boiling point:
349.21°C (rough estimate)
Density 
1.216
refractive index 
1.4825 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly)
form 
Solid
pka
6.98±0.35(Predicted)
color 
Needles from H2O
Water Solubility 
Slightly soluble in water.
BRN 
1914746
Stability:
Hygroscopic
InChIKey
WXNRYSGJLQFHBR-UHFFFAOYSA-N
LogP
3.091 (est)
CAS DataBase Reference
131-55-5(CAS DataBase Reference)
NIST Chemistry Reference
2,2',4,4'-Tetrahydroxybenzophenone(131-55-5)
EPA Substance Registry System
2,2',4,4'-Tetrahydroxybenzophenone (131-55-5)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
DJ1892000
TSCA 
Yes
HS Code 
29145090
Hazardous Substances Data
131-55-5(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 1220mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T16403
Product name
2,2′,4,4′-Tetrahydroxybenzophenone
Purity
97%
Packaging
25g
Price
$62.4
Updated
2024/03/01
Sigma-Aldrich
Product number
T16403
Product name
2,2′,4,4′-Tetrahydroxybenzophenone
Purity
97%
Packaging
100g
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
T0118
Product name
2,2',4,4'-Tetrahydroxybenzophenone
Purity
>98.0%(HPLC)
Packaging
25g
Price
$39
Updated
2024/03/01
Alfa Aesar
Product number
A10237
Product name
2,2',4,4'-Tetrahydroxybenzophenone, 98+%
Packaging
25g
Price
$39.65
Updated
2024/03/01
Alfa Aesar
Product number
A10237
Product name
2,2',4,4'-Tetrahydroxybenzophenone, 98+%
Packaging
100g
Price
$108.65
Updated
2024/03/01
More
Less

2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties,Usage,Production

Application

2,2',4,4'-Tetrahydroxybenzophenone (BZP-2) is water-soluble and light-yellow powder (figure 1). BZP-2 is widely used in perfumes to prevent their degradation due to light. BZP-2 is a UV-absorber that helps protect against product degradation because of UV-light exposure and it is widely used in sunscreens and in cosmetics (figure 2), such as: anti-aging” creams and hair sprays and shampoos, paints and plastics. It can also mask odor associated with a formulation’s composition. In addition, the hypolipemiant drug fenofibrate is also a substituted benzophenone.

Potential Exposure & Risk

Although 2,2',4,4'-Tetrahydroxybenzophenone is used as a UV-blocker in cosmetics, plastics and automotive car products, its safety issue still should be noted. Such as workers that use BZP-2 may breathe in dust or have direct skin contact and the general population may be exposed by dermal contact with products containing this compound.
Skin allergic reaction has been reported in some people using sunscreens or cosmetics containing this compound. 2,2',4,4'-Tetrahydroxybenzophenone(BZP-2) is a member of a group of chemicals known as endocrine disruptors, which may alter the function and/or development of the reproductive system. Limited evidence indicates that exposure to benzophenone UV-absorbing chemicals, including BZP-2, is associated with an altered ratio of males to females at birth (increased females).

Chemical Properties

yellow to brown crystalline powder

Uses

2,2′,4,4′-Tetrahydroxybenzophenone are benzophenone-type UV filters with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.

Uses

2,2',4,4'-Tetrahydroxybenzophenone is used as the raw material of ultraviolet absorbers in cosmetics, plastics, resins and rubber. It is used as pharmaceutical intermediates and light-sensitive materials. It is also used as pharmaceutical adjuvant.

Uses

2,2',4,4'-Tetrahydroxybenzophenone is a uV-absorber that helps protect against product degradation because of uV-light exposure. It can also mask odor associated with a formulation’s composition.

Preparation

Obtained (small amount) by melting a fluorescin chloride/sodium hydroxide mixture in the presence of a very few water at 230–240° for 2–3 h.

Contact allergens

BZP-2 is widely used in perfumes to prevent their degradation due to light. It can cause allergic contact dermatitis.

Safety Profile

Moderately toxic by ingestion. Aneye irritant. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.

Synthesis

2 mol of resorcinol dimethyl ether is added dropwise to a mixture of 1 mol of phosgene and 1 mol of aluminum chloride, and the mixture is heated to 65-80° C at a temperature of 30-40° C in the presence of a chlorinated hydrocarbon selected from aliphatic and aromatic chlorides, such as ethylene dichloride. It is then cooled to 40° C, 2 to 3 mol of aluminum chloride are added, the mixture is heated to 60-70° C, dilute hydrochloric acid is treated with aqueous sodium hydroxide solution, and 2,2',4,4'-Tetrahydroxybenzophenone is isolated by filtration.

2,2',4,4'-Tetrahydroxybenzophenone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,2',4,4'-Tetrahydroxybenzophenone Suppliers

Belgium 5 Canada 1 China 399 Europe 3 France 1 Germany 11 India 12 Japan 7 Slovakia 1 South Korea 3 Switzerland 3 The Netherlands 3 Ukraine 1 United Kingdom 23 United States 48 USA 1 Global 522
Alkemi BVBA
Tel
--
Fax
--
Email
nfo@alkemi.be
Country
Belgium
ProdList
2201
Advantage
58
Kreglinger Europe nv
Tel
--
Fax
--
Email
info@kreglinger.com
Country
Belgium
ProdList
119
Advantage
58
Acros Organics (Part of Thermo Fisher Scientific )
Tel
--
Fax
--
Email
fo@acros.com
Country
Belgium
ProdList
3824
Advantage
58
TCI EUROPE N.V.
Tel
--
Fax
--
Email
sales@tcieurope.be
Country
Belgium
ProdList
2200
Advantage
66
Maybridge Chemical Co., Ltd.
Tel
--
Fax
--
Country
Belgium
ProdList
6293
Advantage
73
More
Less

View Lastest Price from 2,2',4,4'-Tetrahydroxybenzophenone manufacturers

Jinan Finer Chemical Co., Ltd
Product
2,2',4,4'-Tetrahydroxybenzophenone 131-55-5
Price
US $5.00/kg
Min. Order
1kg
Purity
≥99%
Supply Ability
500mt/year
Release date
2022-10-18
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Benzophenone-2 131-55-5
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-14
Watson Biotechnology Co.,Ltd
Product
Benzophenone-2(BP-2) 131-55-5
Price
US $200.00-130.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-07-27

131-55-5, 2,2',4,4'-TetrahydroxybenzophenoneRelated Search:

2,3,4-Trihydroxybenzoic acid Disodium 2,2'-dihydroxy-4,4'-dimethoxy-5,5'-disulfobenzophenone 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone 3,4-Dihydroxybenzophenone 2,4-Dihydroxybenzophenone Benzophenone Benzophenone imine 4-Hydroxybenzophenone 4,4'-Dihydroxybenzophenone UV Absorber 326 Octabenzone 2,2'-Thiobis(4-tert-octylphenolato)-n-butylamine nickel(II) Poly[N,N'-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine-co-2,4-dichloro-6-morpholino-1,3,5-triazine] UV Absorber 400 Tinuvin-1130 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid N-(2-Ethoxyphenyl)-N'-(4-ethylphenyl)-ethlyene diamide 2-Phenylbenzimidazole-5-sulfonic acid

  • 2,2,4,4-Tetrahydroxybenzophenol
  • 2,2’,4,4’-tetrahydroxy-benzophenon
  • 2,2’,4,4’-tetrehydroxybenzophenone
  • 2,2,4,4 TETRAHYDROXY BENZOPHENONE
  • 2,4,2',4'-Tetrahydroxybenzophenone
  • 2,4,2’,4’-tetrahydroxybenzophenone
  • Benzophenone, 2,2',4,4'-tetrahydroxy-
  • bis(2,4-dihydroxyphenyl)-methanon
  • Methanone, bis(2,4-dihydroxyphenyl)-
  • Uvinol D-50
  • Uvinul D-50
  • uvinuld-50
  • UV Absorber BP2
  • 2,2',4,4'-Tetrahydroxybenzophenone (UV 246)
  • Benzophenone-2 (2,2'4,4'-Terahydroxy Benzophenone)
  • Benzophenone, 2,2'
  • 2,2',4,4'-tetrahyroxybenzophenone
  • 2,2',4,4'-TETRAHYDROXYBENZOPHENONE
  • DI(2,4-DIHYDROXYPHENYL)METHANONE
  • BENZOPHENONE-2
  • BENZOPHENONE-2-(2,2',4,4'-TETRAHYDROXYBENZOPHENONE)
  • BIS-(2,4-DIHYDROXY-PHENYL)-METHANONE
  • 2,2',4,4'-Tetrahydroxybenzophenone(bp-2)
  • TIMTEC-BB SBB003178
  • 2,2',4,4'-Tetrahydroxybenzophe
  • 2.2''-4.4''-TETRAHYD[CL]ROXYBENZOPHENONE
  • 2,2'',4,4''-TETRAHYDROXYBENZOPHENONE 98+%
  • 2,2',4,4'-tetrahydroxy Benzophenone(Benzophenone-2)
  • Seesorb 106
  • Sumisorb 150
  • 70A-196
  • TETRAHYDROXYBENZOPHENONE
  • 2,2',4,4'-Tetrahydroxybenzophenone,97%
  • 4-[(2,4-dihydroxyphenyl)carbonyl]benzene-1,3-diol
  • 2,2',4,4'-Tetrahydroxybenzophenone&gt
  • UV Absorber Benzophenone-2
  • 2,2’,4,4’-Tetrahydroxybenzophenone Solution in Acetonitrile, 100μg/mL
  • 2,2',4,4'-Tetrahydroxybenzophenone ISO 9001：2015 REACH
  • UV ABSORBER TRUELICHT BP-2
  • 2,2',4,4'-tetrahydroxy Benzophenone,Benzophenone-2(BP-2)
  • High purity CAS 131-55-5 2,2',4,4'-Tetrahydroxybenzophenone in stock
  • 2,2',4,4'-Tetrahydroxybenzop
  • Sinosorb? BP-2
  • Phloroglucinol Impurity 88
  • 2,2',4,4'-Tetrahydroxybenzophenone
  • 2,2',4,4'-Tetrehydroxybenzophenone
  • 2,2',4,4'-Tetrahydroxybenzophenone(BP-2)
  • Benzophenone-2(BP-2)
  • Zolmitriptan Impurity 1-d6
  • 2,2',4,4'-Tetrahydroxybenzophenone in methanol
  • 2,2',4,4'-Tetrehydroxybenzophenone (BP-2)
  • 2,2′,4,4'-Tetrahydroxybenzophenone
  • 131-55-5
  • C13H10O5
  • HO2C6H32CO
  • Ketones
  • Organic Building Blocks
  • Benzophenones (for High-Performance Polymer Research)