3-FLUORO-4-METHOXYBENZYL BROMIDE

Product Name: 3-FLUORO-4-METHOXYBENZYL BROMIDE
CAS No.: 331-61-3
Chemical Name: 3-FLUORO-4-METHOXYBENZYL BROMIDE
Synonyms: 3-FLUORO-4-METHOXYBENZYL BROMIDE;3-Fluoro-4-methoxybenzyl bromide ,98%;4-(broMoMethyl)-2-fluoro-1-Methoxybenzene;Benzene, 4-(bromomethyl)-2-fluoro-1-methoxy-;4-(Bromomethyl)-2-fluoroanisole, 4-(Bromomethyl)-2-fluoro-1-methoxybenzene, 4-(Bromomethyl)-2-fluorophenyl methyl ether
CBNumber: CB1711732
Molecular Formula: C8H8BrFO
Formula Weight: 219.05
MOL File: 331-61-3.mol

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3-FLUORO-4-METHOXYBENZYL BROMIDE Property

Melting point:: 44-46°C
Boiling point:: 149-155 °C(Press: 25-28 Torr)
Density: 1.488±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: Red
Sensitive: Lachrymatory
CAS DataBase Reference: 331-61-3(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xn
Risk Statements: 36/37/38-52-22-34
Safety Statements: 26-36/37/39-45
RIDADR: UN3261
Hazard Note: Corrosive/Lachrymatory
HazardClass: 8
PackingGroup: III
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: F599395
Product name: 3-Fluoro-4-methoxybenzylBromide
Packaging: 1g
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 013839
Product name: 3-Fluoro-4-methoxybenzyl bromide
Packaging: 1g
Price: $10
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2707-B-34
Product name: 3-Fluoro-4-methoxybenzyl bromide
Purity: 98%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Matrix Scientific

Product number: 008958
Product name: 3-Fluoro-4-methoxybenzyl bromide
Purity: 98%
Packaging: 5g
Price: $23
Updated: 2021/12/16

Oakwood

Product number: 013839
Product name: 3-Fluoro-4-methoxybenzyl bromide
Packaging: 5g
Price: $30
Updated: 2021/12/16

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3-FLUORO-4-METHOXYBENZYL BROMIDE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

96047-32-4

331-61-3

The general procedure for the synthesis of 3-fluoro-4-methoxybenzyl bromide from (3-fluoro-4-methoxyphenyl)methanol was as follows: at room temperature, (3-fluoro-4-methoxyphenyl)methanol (2.35 g, 15.05 mmol) and triethylamine (3.15 mL, 22.58 mmol) were dissolved in anhydrous dichloromethane (50 mL). Subsequently, methanesulfonyl chloride (1.41 mL, 18.06 mmol) was added dropwise. After 15 minutes of reaction, the reaction mixture was diluted with dichloromethane (50 mL) and the organic layer was washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was dissolved in anhydrous acetone (100 mL), excess lithium bromide was added and the mixture was heated to reflux for 30 minutes. After the reaction was complete, the solution was cooled and the solvent was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water and the aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 3-fluoro-4-methoxybenzyl bromide (3.00 g, 91% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ7.16-7.07 (2H, m), 6.90 (1H, dd, J=8.3,8.4Hz), 4.45 (2H, s), 3.89 (3H, s).

References

[1] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0120
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 24, p. 6842 - 6846
[3] Chemical Biology and Drug Design, 2016, p. 97 - 109

3-FLUORO-4-METHOXYBENZYL BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-METHOXYBENZYL BROMIDE Suppliers

China 76 Germany 4 India 5 Italy 1 The Netherlands 1 United Kingdom 18 United States 22 Global 127

Aladdin Scientific

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View Lastest Price from 3-FLUORO-4-METHOXYBENZYL BROMIDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-FLUORO-4-METHOXYBENZYL BROMIDE 331-61-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-03

Career Henan Chemical Co

Product: 3-FLUORO-4-METHOXYBENZYL BROMIDE 331-61-3
Price: US $1.00/KG
Min. Order: 1IU
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

331-61-3, 3-FLUORO-4-METHOXYBENZYL BROMIDERelated Search:

3-FLUORO-4-METHOXYBENZYL BROMIDE

3-Fluoro-4-methoxybenzyl bromide ,98%

4-(broMoMethyl)-2-fluoro-1-Methoxybenzene

4-(Bromomethyl)-2-fluoroanisole, 4-(Bromomethyl)-2-fluoro-1-methoxybenzene, 4-(Bromomethyl)-2-fluorophenyl methyl ether

Benzene, 4-(bromomethyl)-2-fluoro-1-methoxy-

331-61-3

Fluorine series