4-(Bromomethyl)benzeneboronic acid pinacol ester

Product Name: 4-(Bromomethyl)benzeneboronic acid pinacol ester
CAS No.: 138500-85-3
Chemical Name: 4-(Bromomethyl)benzeneboronic acid pinacol ester
Synonyms: 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)benzyl BroMide;4-(Bromomethyl)phenylboronic acid pinacol;4-BROMOMETHYLPHENYLBORONIC ACID, PINACOL ESTER;4-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER;4-Bromomethylphenylboronic acid pinacol ester 95%;4-(BROMOMETHYL)BENZENEBORONICACIDPINACOLESTER,95%;tert-butyl 3-allyl-3-hydroxyazetidine-61-carboxylate;4-(bromomethyl)phenylboronic acid pinacol cyclic ester;4-(Bromomethyl)benzeneboronic acid pinacol cyclic ester;4-Bromomethylphenylboronic acid, pinacol ester - [B1882]
CBNumber: CB1713271
Molecular Formula: C13H18BBrO2
Formula Weight: 297
MOL File: 138500-85-3.mol

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4-(Bromomethyl)benzeneboronic acid pinacol ester Property

Melting point:: 85-89 °C
Boiling point:: 351.2±25.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Toluene
form: powder
color: white to off-white
BRN: 7921808
InChI: InChI=1S/C13H18BBrO2/c1-12(2)13(3,4)17-14(16-12)11-7-5-10(9-15)6-8-11/h5-8H,9H2,1-4H3
InChIKey: CBUOGMOTDGNEAW-UHFFFAOYSA-N
SMILES: O1C(C)(C)C(C)(C)OB1C1=CC=C(CBr)C=C1
CAS DataBase Reference: 138500-85-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-34
Safety Statements: 26-36/37/39-45
RIDADR: 3261
WGK Germany: 3
Hazard Note: Harmful/Irritant/Keep Cold
TSCA: No
HazardClass: IRRITANT
HazardClass: 8
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 718513
Product name: 4-Bromomethylphenylboronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $122
Updated: 2025/07/31

Sigma-Aldrich

Product number: 718513
Product name: 4-Bromomethylphenylboronic acid pinacol ester
Purity: 95%
Packaging: 5g
Price: $206
Updated: 2025/07/31

TCI Chemical

Product number: T2945
Product name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: T2945
Product name: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Bromide
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $89
Updated: 2025/07/31

TRC

Product number: B685680
Product name: 2-[4-(Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Packaging: 2.5g
Price: $165
Updated: 2021/12/16

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4-(Bromomethyl)benzeneboronic acid pinacol ester Chemical Properties,Usage,Production

Description

4-(Bromomethyl)benzeneboronic acid pinacol ester can be used as an active oxygen source in biological assays, such as functional assays, because it generates reactive oxygen species and can act as a fluorescence probe for detection of biological samples.

Chemical Properties

White powder

Uses

4-(Bromomethyl)benzeneboronic acid pinacol ester is used in the synthesis of metalloproteinase-13 inhibitors in the treatment of osteoarthritis.

Synthesis

Pinacol p-tolueneborate (10.91g, 50.0mmol), bromosuccinimide (NBS, 9.91g, 55.0mmol), and azobisisobutyronitrile (AIBN, 0.44g, 2.0mmol) were dissolved in dry of carbon tetrachloride (CCl4, 200 mL), stirred at reflux for 14 hours. The mixture was filtered, the solvent was evaporated, and the mixture was dissolved in ethyl acetate (200 mL). Wash once with distilled water (100 mL) and saturated sodium chloride aqueous solution (100 mL), dry with anhydrous sodium sulfate, and rotary evaporate. Finally, use petroleum ether as the eluent for column chromatography separation to obtain 4-(Bromomethyl)benzeneboronic acid pinacol ester (11.30g, yield 76.1%).

References

[1] Patent: WO2013/25885, 2013, A1. Location in patent: Paragraph 0086
[2] Synthetic Communications, 2002, vol. 32, # 17, p. 2669 - 2676
[3] Patent: EP2450354, 2012, A1

4-(Bromomethyl)benzeneboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(Bromomethyl)benzeneboronic acid pinacol ester manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: 4-(Bromomethyl)benzeneboronic acid pinacol ester 138500-85-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-17

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(Bromomethyl)benzeneboronic acid pinacol ester 138500-85-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Henan Fengda Chemical Co., Ltd

Product: 4-(Bromomethyl)benzeneboronic acid pinacol ester 138500-85-3
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-10

138500-85-3, 4-(Bromomethyl)benzeneboronic acid pinacol esterRelated Search:

Potassium carbonate Sodium Methoxide 4-Ethylphenylboronic acid 2-(4-Hexyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,1,3-benzothiadiazole Pinacol 2-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER 3-(Bromomethyl)benzeneboronic acid, pinacol ester 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)TOLUENE 4-(Bromomethyl)phenylboronic acid 4-(Bromomethyl)benzeneboronic acid pinacol ester Filgotinib

4-Bromomethylphenylboronic acid pinacol ester 95%

4-(BROMOMETHYL)BENZENEBORONIC ACID PINACOL ESTER

4-BROMOMETHYLPHENYLBORONIC ACID, PINACOL ESTER

4-(Bromomethyl)benzeneboronic acid pinacol cyclic ester

4-(Bromomethyl)phenylboronic acid pinacol cyclic ester~2-[(4-Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-(Bromomethyl)phenylboronicacidpinacolcyclicester~2-[(4-Bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-[(4-bromomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-(bromomethyl)phenylboronic acid pinacol cyclic ester

4-BroMoMethylphenylboronic acid pinacol ester 2-(4-BroMoMethyl-phenyl)-4,4,5,5-tetraMethyl-[1,3,2]dioxaborolane 4-(BroMoMethyl)benzeneboronic acid pinacol ester

2-(4-(BroMoMe thyl)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolaMe

4-(Bromomethyl)phenylboronic acid pinacol

4-(BROMOMETHYL)BENZENEBORONICACIDPINACOLESTER,95%

4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)benzyl BroMide

1,3,2-Dioxaborolane, 2-[4-(bromomethyl)phenyl]-4,4,5,5-tetramethyl-

tert-butyl 3-allyl-3-hydroxyazetidine-61-carboxylate

4-Bromomethylphenylboronic acid, pinacol ester - [B1882]

138500-85-3

1358500-85-3

Boronic acids

blocks

BoronicAcids

Bromides