HYPOPHYLLANTHIN

ChemicalBook > CAS DataBase List > HYPOPHYLLANTHIN

Product Name: HYPOPHYLLANTHIN
CAS No.: 33676-00-5
Chemical Name: HYPOPHYLLANTHIN
Synonyms: NSC 619044;HYPOPHYLLANTIN;HYPOPHYLLANTHIN;(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole;(7S,8S,9R)-9-(3,4-Dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)naphtho[1,2-d]-1,3-dioxole;Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7S,8S,9R)-;Inhibitor,CD243,Pgp,inhibit,Hypophyllanthin,ABCB1,P-glycoprotein,P-gp,Cluster of differentiation 243,Multidrug resistance protein 1,MDR1
CBNumber: CB1716924
Molecular Formula: C24H30O7
Formula Weight: 430.49
MOL File: 33676-00-5.mol

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HYPOPHYLLANTHIN Property

Melting point:: 129-130℃
Boiling point:: 511.1±50.0 °C(Predicted)
Density: 1.158
storage temp.: 4°C, protect from light
solubility: ≤0.2mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
LogP: 3.770 (est)

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89713
Product name: Hypophyllanthin
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $873
Updated: 2024/03/01

Cayman Chemical

Product number: 11715
Product name: Hypophyllanthin
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 11715
Product name: Hypophyllanthin
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 11715
Product name: Hypophyllanthin
Purity: ≥98%
Packaging: 10mg
Price: $448
Updated: 2024/03/01

Cayman Chemical

Product number: 11715
Product name: Hypophyllanthin
Purity: ≥98%
Packaging: 25mg
Price: $965
Updated: 2024/03/01

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HYPOPHYLLANTHIN Chemical Properties,Usage,Production

Description

Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity. In Caco-2 cells 100 μM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.

Uses

Hypophyllanthin can be used to study the modulation of NSAID-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants.

in vitro

previous study found that hypophyllanthin could inhibit p-gp function with comparable potencies, but could not affect mrp2 activity. when hypophyllanthin was washed out before addition of substrate, the inhibitory action against p-gp function was lost. these results indicated the reversibility of the inhibition. moreover, prolonged exposure of the caco-2 cells to hypophyllanthin up to 7 days had no effect on p-gp function [1].

in vivo

a previous study was conducted to evaluate the effect of carbofuran on estrous cycle and follicular growth in virgin wister rats as well as recovering from the damaged estrous cycle with treatment of hypophyllanthin. hypophyllanthin is non-steroidal plant molecule with estrogen-like activities, but with an estrogen-type activity. hypophyllanthin was capable of interacting with estrogen receptors, showing both agonist and antagonist methods of action. therefore, hypophyllanthin was found to be systemically transformed into enterolignan, which is known to be responsible for augmenting estrus cycle in rats [2].

References

[1] n. sukhaphirom, n. vardhanabhuti, h. chirdchupunseree, et al. phyllanthin and hypophyllanthin inhibit function of p-gp but not mrp2 in caco-2 cells. journal of pharmacy and pharmacology 65, 292-299 (2012).
[2] aminul islam et al. estrogenic properties of phyllanthin and hypophyllanthin from phyllanthus amarus against carbofuran induced toxicity in female rats. pharmacologyonline 3: 1006-1016 (2008).

HYPOPHYLLANTHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HYPOPHYLLANTHIN manufacturers

Career Henan Chemical Co

Product: HYPOPHYLLANTHIN 33676-00-5
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

33676-00-5, HYPOPHYLLANTHINRelated Search:

(1S,3aR,4R,6aR)-4-(3,5-Dimethoxyphenyl)tetrahydro-1-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan PHYLLANTHIN Benzoylgomisin O Anwuligan 4'-Demethylpodophyllotoxin 4'-Demethylepipodophyllotoxin (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside ENTERODIOL SECOISOLARICIRESINOL Masoprocol (+)-ISOLARICIRESINOL Terameprocol HYPOPHYLLANTHIN Dihydromyristicin 2,3,4,4'-TETRAHYDROXYDIPHENYLMETHANE Niranthin HYPOPHYLLANTHIN(P) HYPOPHYLLANTHIN(PRIMARY STANDARD)

HYPOPHYLLANTHIN

HYPOPHYLLANTIN

(7S,8S,9R)-9-(3,4-Dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)naphtho[1,2-d]-1,3-dioxole

NSC 619044

Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7S,8S,9R)-

(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole

Inhibitor,CD243,Pgp,inhibit,Hypophyllanthin,ABCB1,P-glycoprotein,P-gp,Cluster of differentiation 243,Multidrug resistance protein 1,MDR1

33676-00-5