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HYPOPHYLLANTHIN

Product Name
HYPOPHYLLANTHIN
CAS No.
33676-00-5
Chemical Name
HYPOPHYLLANTHIN
Synonyms
NSC 619044;HYPOPHYLLANTIN;HYPOPHYLLANTHIN;Hypophyllanthin-RM;(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole;(7S,8S,9R)-9-(3,4-Dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)naphtho[1,2-d]-1,3-dioxole;Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7S,8S,9R)-;Inhibitor,CD243,Pgp,inhibit,Hypophyllanthin,ABCB1,P-glycoprotein,P-gp,Cluster of differentiation 243,Multidrug resistance protein 1,MDR1
CBNumber
CB1716924
Molecular Formula
C24H30O7
Formula Weight
430.49
MOL File
33676-00-5.mol
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HYPOPHYLLANTHIN Property

Melting point:
129-130℃
Boiling point:
511.1±50.0 °C(Predicted)
Density 
1.158
storage temp. 
4°C, protect from light
solubility 
≤0.2mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
crystalline solid
color 
White to off-white
LogP
3.770 (est)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89713
Product name
Hypophyllanthin
Purity
phyproof? Reference Substance
Packaging
10mg
Price
$873
Updated
2024/03/01
Cayman Chemical
Product number
11715
Product name
Hypophyllanthin
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
11715
Product name
Hypophyllanthin
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
11715
Product name
Hypophyllanthin
Purity
≥98%
Packaging
10mg
Price
$448
Updated
2024/03/01
Cayman Chemical
Product number
11715
Product name
Hypophyllanthin
Purity
≥98%
Packaging
25mg
Price
$965
Updated
2024/03/01
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HYPOPHYLLANTHIN Chemical Properties,Usage,Production

Description

Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity. In Caco-2 cells 100 μM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.

Uses

Hypophyllanthin can be used to study the modulation of NSAID-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants.

in vitro

previous study found that hypophyllanthin could inhibit p-gp function with comparable potencies, but could not affect mrp2 activity. when hypophyllanthin was washed out before addition of substrate, the inhibitory action against p-gp function was lost. these results indicated the reversibility of the inhibition. moreover, prolonged exposure of the caco-2 cells to hypophyllanthin up to 7 days had no effect on p-gp function [1].

in vivo

a previous study was conducted to evaluate the effect of carbofuran on estrous cycle and follicular growth in virgin wister rats as well as recovering from the damaged estrous cycle with treatment of hypophyllanthin. hypophyllanthin is non-steroidal plant molecule with estrogen-like activities, but with an estrogen-type activity. hypophyllanthin was capable of interacting with estrogen receptors, showing both agonist and antagonist methods of action. therefore, hypophyllanthin was found to be systemically transformed into enterolignan, which is known to be responsible for augmenting estrus cycle in rats [2].

References

[1] n. sukhaphirom, n. vardhanabhuti, h. chirdchupunseree, et al. phyllanthin and hypophyllanthin inhibit function of p-gp but not mrp2 in caco-2 cells. journal of pharmacy and pharmacology 65, 292-299 (2012).
[2] aminul islam et al. estrogenic properties of phyllanthin and hypophyllanthin from phyllanthus amarus against carbofuran induced toxicity in female rats. pharmacologyonline 3: 1006-1016 (2008).

HYPOPHYLLANTHIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HYPOPHYLLANTHIN Suppliers

China 63 Germany 1 India 3 United Kingdom 2 United States 10 USA 1 Global 80
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from HYPOPHYLLANTHIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
HYPOPHYLLANTHIN 33676-00-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-15
Career Henan Chemical Co
Product
HYPOPHYLLANTHIN 33676-00-5
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

33676-00-5, HYPOPHYLLANTHINRelated Search:

(1S,3aR,4R,6aR)-4-(3,5-Dimethoxyphenyl)tetrahydro-1-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan PHYLLANTHIN Benzoylgomisin O Anwuligan 4'-Demethylpodophyllotoxin 4'-Demethylepipodophyllotoxin (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside ENTERODIOL SECOISOLARICIRESINOL Masoprocol (+)-ISOLARICIRESINOL Terameprocol HYPOPHYLLANTHIN Dihydromyristicin 2,3,4,4'-TETRAHYDROXYDIPHENYLMETHANE Niranthin HYPOPHYLLANTHIN(P) HYPOPHYLLANTHIN(PRIMARY STANDARD)

  • HYPOPHYLLANTHIN
  • HYPOPHYLLANTIN
  • (7S,8S,9R)-9-(3,4-Dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)naphtho[1,2-d]-1,3-dioxole
  • NSC 619044
  • Naphtho[1,2-d]-1,3-dioxole,9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-,(7S,8S,9R)-
  • (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
  • Inhibitor,CD243,Pgp,inhibit,Hypophyllanthin,ABCB1,P-glycoprotein,P-gp,Cluster of differentiation 243,Multidrug resistance protein 1,MDR1
  • Hypophyllanthin-RM
  • 33676-00-5