ChemicalBook > CAS DataBase List > 2,6-Dichloropurine

2,6-Dichloropurine

Product Name
2,6-Dichloropurine
CAS No.
5451-40-1
Chemical Name
2,6-Dichloropurine
Synonyms
2,6-DICHLORO-9H-PURINE;2,6-dichloro-7H-purine;2,6-dichloro-1H-purine;NSC 18395;Dichloropurine;6-Dichloropurine;2,6-DICHLOROPURINE;Cefepime Intermediate;2,6-Dichloropurine>2,6-Dichloropurine.97%
CBNumber
CB1720642
Molecular Formula
C5H2Cl2N4
Formula Weight
189
MOL File
5451-40-1.mol
More
Less

2,6-Dichloropurine Property

Melting point:
185-195 °C (dec.) (lit.)
Boiling point:
310.62°C (rough estimate)
Density 
1.7265 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble
form 
Crystalline Powder
pka
5.22±0.20(Predicted)
color 
White to yellow
Water Solubility 
soluble
BRN 
9354
InChIKey
RMFWVOLULURGJI-UHFFFAOYSA-N
CAS DataBase Reference
5451-40-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-22
Safety Statements 
22-24/25-37/39-26-36
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D73103
Product name
2,6-Dichloropurine
Purity
97%
Packaging
1g
Price
$17.48
Updated
2024/03/01
Sigma-Aldrich
Product number
D73103
Product name
2,6-Dichloropurine
Purity
97%
Packaging
5g
Price
$83.2
Updated
2024/03/01
TCI Chemical
Product number
D2470
Product name
2,6-Dichloropurine
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
D2470
Product name
2,6-Dichloropurine
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$60
Updated
2024/03/01
Alfa Aesar
Product number
B21289
Product name
2,6-Dichloropurine, 97%
Packaging
1g
Price
$76.65
Updated
2024/03/01
More
Less

2,6-Dichloropurine Chemical Properties,Usage,Production

Description

2,6-Dichloropurine is an important pharmaceutical intermediate. It is widely used in the preparation of purine nucleosides and purine nucleotides[1].

Chemical Properties

white to light yellow crystal powder

Uses

Suzuki-Miyaura cross-coupling between halopurines and arylboronic acids in water-acetonitrile.1

Uses

2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 404, 1958 DOI: 10.1021/ja01535a040

Synthesis

2,6-Dichloropurine is prepared in two main ways:
(1) By chlorination of the purine ring structure, e.g., chlorination of xanthine (2,6-dihydroxypurine) with pyrophosphoryl chloride at high temperatures in sealed tubes in the presence of a phase-transfer catalyst or with phosphorus oxychloride under reflux, and chlorination of 6-chloropurine, hypoxanthine, or their N-oxides with phosphorus oxychloride, and chlorination with chlorine gas at low temperatures. Chlorination of 2,6-dithiopurine.
(2) The purine ring is constructed using barbituric acid derivatives or 2,4-dichloro-5,6-diaminopyridine as starting materials. However, both methods are not very suitable for industrial production.
The industrial preparation of 2,6-dichloropurine involves the direct chlorination of xanthine with phosphorus trichloride and a weakly nucleophilic organic base (e.g., amidine, guanidine base, or proton sponge)[1]. The reaction process is shown below:


Purification Methods

It can be recrystallised from 150 parts of boiling H2O and dried at 100o to constant weight. It is soluble in EtOAc. The HgCl2 salt separates from EtOH solution. UV: max 275nm ( 8.9K) at pH 1; and 280nm ( 8.5K) at pH 11 [Elion & Hitchings J Am Chem Soc 78 3508 1956, Schaeffer & Thomas J Am Chem Soc 80 3738 1958, Beaman & Robins J Appl Chem (London) 12 432 1962, Montgomery J Am Chem Soc 78 1928 1956]. [Beilstein 26 III/IV 1747.]

References

[1] QI ZENG. Facile and Practical Synthesis of 2,6-Dichloropurine[J]. Organic Process Research & Development, 2004, 8 6: 962-963. DOI:10.1021/op049878r.

2,6-Dichloropurine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,6-Dichloropurine Suppliers

Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
17777
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-(817)863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Fisher Scientific
Tel
--
Fax
--
Email
sales@fishersci.com
Country
United States
ProdList
2337
Advantage
86
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Natland International Corporation
Tel
--
Fax
--
Country
United States
ProdList
314
Advantage
42
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
ChemContract Research Inc.
Tel
--
Fax
--
Country
United States
ProdList
1526
Advantage
38
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AnsisChem
Tel
--
Fax
--
Country
United States
ProdList
409
Advantage
38
Albany Molecular Research
Tel
--
Fax
--
Email
info@amriglobal.com
Country
United States
ProdList
229
Advantage
80
Altan Corporation
Tel
--
Fax
--
Email
OrderingService@AltanBiochemicals.com
Country
United States
ProdList
1161
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Precursor Chemicals, Inc.
Tel
--
Fax
--
Email
info@precursorchem.com
Country
United States
ProdList
347
Advantage
51
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
Morre-Tec Industries, Inc.
Tel
--
Fax
--
Email
sales@morretec.com
Country
United States
ProdList
169
Advantage
64
Chembargains
Tel
--
Fax
--
Email
info@chembargains.com
Country
United States
ProdList
178
Advantage
69
Advanced Molecular Technologies
Tel
--
Fax
--
Email
enquiries@amtechpl.com
Country
United States
ProdList
136
Advantage
38
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
More
Less

View Lastest Price from 2,6-Dichloropurine manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
2,6-Dichloropurine 5451-40-1
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-15
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2,6-Dichloropurine 5451-40-1
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-11-19
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2,6-Dichloropurine 5451-40-1
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min
Supply Ability
100KG
Release date
2021-06-01

5451-40-1, 2,6-DichloropurineRelated Search:


  • 2,6-DICHLORO-9H-PURINE
  • 2,6-DICHLOROPURINE
  • 2,6-Dichloropurine.97%
  • 2,6-dichloro-1H-purine
  • 1H-Purine, 2,6-dichloro-
  • Dichloropurine
  • Cefepime Intermediate
  • 2,6-dichloro-7H-purine
  • 9H-Purine, 2,6-dichloro-
  • 6-Dichloropurine
  • NSC 18395
  • 2,6-Dichloropurine&gt
  • 2,6-Dichloropurine USP/EP/BP
  • 5451-40-1
  • 2001-2-5
  • 5451-41-0
  • C5H2ClN4
  • HETERO CHLORIDE
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Purines
  • Building Blocks
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Nucleotides
  • Fused Ring Systems
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • PurinesHeterocyclic Building Blocks
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleic acids
  • Bases & Related Reagents
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Halides
  • Purine
  • Nucleotides and Nucleosides
  • Purines
  • FINE Chemical & INTERMEDIATES
  • Starting Raw Materials & Intermediates
  • Heterocycles
  • 5451-40-1