BOC-D-TYR-OME
- Product Name
- BOC-D-TYR-OME
- CAS No.
- 76757-90-9
- Chemical Name
- BOC-D-TYR-OME
- Synonyms
- (R)-Methyl 2-((tert-butoxycarbonyl)aMino)-3-(4-hydroxyphenyl)propanoate;BOC-D-TYR-OME;Boc-D-Tyr-Ome-OH;BOC-D-TYROSINE-OME;Boc-D-Tyr-Ome, ≥97%;Boc-
D -Tyr-OMe;BOC-D-TYR-OME USP/EP/BP;Boc-D-tyrosine methyl este;BOC-D-TYROSINE METHYL ESTER;N-BOC-D-tyrosine methyl ester - CBNumber
- CB1721553
- Molecular Formula
- C15H21NO5
- Formula Weight
- 295.33
- MOL File
- 76757-90-9.mol
BOC-D-TYR-OME Property
- Boiling point:
- 452.7±40.0 °C(Predicted)
- Density
- 1.169±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Powder
- pka
- 9.75±0.15(Predicted)
- color
- White
- InChI
- InChI=1S/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(18)20-4)9-10-5-7-11(17)8-6-10/h5-8,12,17H,9H2,1-4H3,(H,16,19)/t12-/m1/s1
- InChIKey
- NQIFXJSLCUJHBB-GFCCVEGCSA-N
- SMILES
- C(OC)(=O)[C@@H](CC1=CC=C(O)C=C1)NC(OC(C)(C)C)=O
- CAS DataBase Reference
- 76757-90-9
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 264899
- Product name
- Boc-D-tyrosine methyl ester
- Packaging
- 2g
- Price
- $202
- Updated
- 2021/12/16
- Product number
- M294248
- Product name
- (R)-Methyl2-((tert-Butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB47944
- Product name
- Boc-D-tyrosine methyl ester
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 04027
- Product name
- Boc-D-tyrosinemethylester,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 1G
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 04027
- Product name
- Boc-D-tyrosinemethylester,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 5G
- Price
- $33.6
- Updated
- 2021/12/16
BOC-D-TYR-OME Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
3728-20-9
76757-90-9
General procedure for the synthesis of butoxycarbonyl-D-tyrosine-methoxylate from di-tert-butyl dicarbonate and (R)-2-amino-3-(4-hydroxyphenyl)propanoic acid methyl ester hydrochloride: potassium carbonate (250.9 g, 1.815 mol) was added to 1.0 L of water with stirring, and under ice-water-bath conditions, (R)-2-amino-3-(4-hydroxyphenyl)propanoic acid methyl ester hydrochloride ( 140.2 g, 0.605 mol), and then di-tert-butyl dicarbonate (158.4 g, 0.726 mol) was added slowly and dropwise. Ethanol (300 mL) was then added. After the dropwise addition, the reaction mixture was naturally warmed to room temperature and stirred for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, extraction was carried out with ethyl acetate (600 mL × 3), the organic phases were combined and washed sequentially with 1N hydrochloric acid (400 mL), water (400 mL) and saturated brine (400 mL × 2), and the organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to obtain a solid product, washed with 300 mL of hexane, and dried to give 175.8 g of white solid product in 98.4% yield.
References
[1] Organic Letters, 2002, vol. 4, # 2, p. 265 - 267
[2] Patent: CN105777584, 2016, A. Location in patent: Paragraph 0114; 0115; 0116
[3] Journal of Organic Chemistry, 2000, vol. 65, # 16, p. 5037 - 5042
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 7, p. 562 - 565
[5] Journal of Organic Chemistry, 1981, vol. 46, # 9, p. 1944 - 1946
BOC-D-TYR-OME Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-D-TYR-OME Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from BOC-D-TYR-OME manufacturers
- Product
- Boc-D-Tyr-Ome 76757-90-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2023-10-11
- Product
- BOC-D-TYR-OME 76757-90-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11