BOC-D-ALA-OME

Product Name: BOC-D-ALA-OME
CAS No.: 91103-47-8
Chemical Name: BOC-D-ALA-OME
Synonyms: BOC-D-ALANINE METHYL ESTER;methyl (tert-butoxycarbonyl)-D-alaninate;BOC-D-ALA-OME;Boc-D-Ala-OMe 99%;N-(tert-Butoxycarbon;Boc-D-methyl alanine;Boc-D-Ala-OMe;BOC-D-ALA-OME USP/EP/BP;D-Boc alanine methyl ester;BOC-D-Alanine methyleester
CBNumber: CB7326428
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 91103-47-8.mol

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BOC-D-ALA-OME Property

Melting point:: 34-37 °C(lit.)
Boiling point:: 341.54°C (rough estimate)
Density: 1.03 g/mL at 25 °C(lit.)
refractive index: 1.4315 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
form: Powder
pka: 11.21±0.46(Predicted)
color: White
optical activity: [α]20/D +45°, c = 1 in methanol
BRN: 4310313
InChI: InChI=1S/C9H17NO4/c1-6(7(11)13-5)10-8(12)14-9(2,3)4/h6H,1-5H3,(H,10,12)/t6-/m1/s1
InChIKey: GJDICGOCZGRDFM-ZCFIWIBFSA-N
SMILES: C(OC)(=O)[C@@H](C)NC(OC(C)(C)C)=O

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Safety

WGK Germany: 3
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC

Product number: B603038
Product name: Boc-D-Ala-OMe
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B603038
Product name: Boc-D-Ala-OMe
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Activate Scientific

Product number: AS27674
Product name: N-Boc-D-Alanine Methyl Ester
Purity: 98+%
Packaging: 5G
Price: $49
Updated: 2021/12/16

Chem-Impex

Product number: 11831
Product name: Boc-D-alaninemethylester,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 5G
Price: $33.6
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49538
Product name: Boc-D-alanine methyl ester
Packaging: 5G
Price: $77.4
Updated: 2021/12/16

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BOC-D-ALA-OME Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

14316-06-4

91103-47-8

General procedure for the synthesis of Boc-D-alanine methyl ester from di-tert-butyl dicarbonate and D-alanine methyl ester hydrochloride: di-tert-butyl dicarbonate (11.7 g, 53.7 mmol) was added to an aqueous solution (100 mL) containing D-alanine methyl ester hydrochloride (5 g, 35.8 mmol) and sodium hydrogen carbonate (9.0 g, 107 mmol). The reaction mixture was stirred at room temperature. Upon completion of the reaction, the reaction mixture was extracted with dichloromethane (DCM, 3 x 100 mL), the organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4). The dried organic phase was filtered and concentrated under reduced pressure. Nuclear magnetic resonance (NMR) analysis of the crude product showed the presence of a large amount of unreacted di-tert-butyl dicarbonate. Therefore, the crude product was dissolved in dichloromethane (DCM, 50 mL), treated with N,N-dimethylethylenediamine (5 mL) and stirred for 30 min. Subsequently, the solution was washed with 1 M hydrochloric acid (HCl, 50 mL), and the organic phase was again dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 5.35 g of Boc-D-alanine methyl ester in 73% yield as a colorless liquid.1H NMR (500 MHz, chloroform-d) δ 5.04 (s,1H), 4.31 (m,1H), 3.73 (s,3H), 1.44 (s,9H), 1.37 (d,J=7.2Hz,3H).

References

[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2299 - 2306
[2] Patent: WO2016/91776, 2016, A1. Location in patent: Page/Page column 387
[3] Heterocycles, 1988, vol. 27, # 9, p. 2077 - 2080
[4] Journal of Organic Chemistry, 1998, vol. 63, # 1, p. 92 - 98
[5] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 4, p. 387 - 398

BOC-D-ALA-OME Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-ALA-OME Suppliers

China 106 Germany 2 India 1 Japan 1 Switzerland 2 United Kingdom 2 United States 13 Global 127

Shandong Lonyuta Pharmaceutical Technology Co., Ltd

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Alfa Aesar

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Energy Chemical

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Jia Xing Isenchem Co.,Ltd

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Accela ChemBio Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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Shandong Xiya Chemical Co., Ltd

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View Lastest Price from BOC-D-ALA-OME manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-Ala-OMe 91103-47-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: Boc-D-Alanine Methyl Ester 91103-47-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: BOC-D-ALA-OME 91103-47-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-23

91103-47-8, BOC-D-ALA-OMERelated Search:

tert-Butoxytrimethylsilane BOC-L-Proline Boc-L-Glutamic acid 1-benzyl ester BOC-GLN-ONP BOC-D-SER-OME BOC-3-IODO-D-ALANINE METHYL ESTER BOC-D-PHENYLALANINE 4-NITROPHENYL ESTER BOC-D-ALA-OME BOC-D-PRO-OME DIETHYL (BOC-AMINO)MALONATE (L)-BOC-PHENYL-ALANINE METHYL ESTER 3-AMINO-N-BOC-L-ALANINE METHYL ESTER BOC-D-Alanine BOC-D-ASN-ONP BOC-3-IODO-D-ALANINE BENZYL ESTER BOC-D-GLU(OTBU)-ONP BOC-D-ASP-OTBU BOC-D-TYR-OME

BOC-D-ALA-OME

BOC-D-ALANINE METHYL ESTER

N-(TERT-BUTOXYCARBONYL)-D-ALANINE METHYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-D-ALANINE METHYL ESTER

Boc-D-alanine methyl ester, N-(tert-Butoxycarbonyl)-D-alanine methyl ester

(R)-methyl 2-(tert-butoxycarbonylamino)propanoate

N-(tert-Butoxycarbon

D-2-tert-butoxycarbonylaMino-propionic acid Methyl ester

methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}propanoate

Boc-D-Alanine Methyl Ester, ≥97%

N-Boc-D-alanine Methyl ester, 98%

methyl (tert-butoxycarbonyl)-D-alaninate

Methyl N-(tert-butoxycarbonyl)-D-alaninate

Boc-D-Ala-OMe 99%

D-Boc alanine methyl ester

Methyl (R)-2-(tert-butoxycarbonylamino)propanoate

Boc-D-alanine methyl ester≥ 99% (HPLC)

BOC-D-Alanine methyleester

(Tert-Butoxy)Carbonyl D-Ala-OMe

D-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

BOC-D-ALA-OME USP/EP/BP

Boc-<SC>D</SC>-Ala-OMe

Boc-D-methyl alanine

N-Boc-D-Alanine Methyl Ester

91103-47-8

Specialty Synthesis

Peptide Synthesis

Amino Acid Derivatives

Alanine