2-Chloro-4-methylsulphonylbenzoic acid
- Product Name
- 2-Chloro-4-methylsulphonylbenzoic acid
- CAS No.
- 53250-83-2
- Chemical Name
- 2-Chloro-4-methylsulphonylbenzoic acid
- Synonyms
- 2-Chloro-4-Met;RARECHEM AL BE 1445;TIMTEC-BB SBB003254;2-Chloro-4-methylsul;Bupropion Impurity 46;2-chloro-4-sulfonyl acid;2-Chloro-4-mesylbenzoic acid;2-chloro-4-methylsulfonylbenzoate;2-Chloro-4-methylsulfonylbenzoic a;2-Chlor-4-(methylsulfonyl)benzoesure
- CBNumber
- CB1724059
- Molecular Formula
- C8H7ClO4S
- Formula Weight
- 234.66
- MOL File
- 53250-83-2.mol
2-Chloro-4-methylsulphonylbenzoic acid Property
- Melting point:
- 192-193 °C
- Boiling point:
- 454.8±45.0 °C(Predicted)
- Density
- 1.4452 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.09±0.25(Predicted)
- form
- Powder
- color
- White to light yellow or light pink
- InChI
- InChI=1S/C8H7ClO4S/c1-14(12,13)5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)
- InChIKey
- CTTWSFIIFMWHLQ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(S(C)(=O)=O)C=C1Cl
- CAS DataBase Reference
- 53250-83-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 41-36/37/38
- Safety Statements
- 36/37/39-26-22-39
- Hazard Note
- Irritant
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C2726
- Product name
- 2-Chloro-4-(methylsulfonyl)benzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- C2726
- Product name
- 2-Chloro-4-(methylsulfonyl)benzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $77
- Updated
- 2025/07/31
- Product number
- OR0264
- Product name
- 2-Chloro-4-(methylsulphonyl)benzoicacid
- Purity
- 97%
- Packaging
- 25g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 6663-5-X6
- Product name
- 2-Chloro-4-(methylsulfonyl)benzoic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- JK365148
- Product name
- 2-Chloro-4-(methylsulfonyl)benzoic Acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
2-Chloro-4-methylsulphonylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
WHITE TO LIGHT YELLOW OR LIGHT PINK POWDER
Synthesis
101349-95-5
53250-83-2
General procedure for the synthesis of 2-chloro-4-methylsulfonylbenzoic acid from compound (CAS:101349-95-5): acetonitrile (4 mL) and compound 5 (100 mg, 0.46 mmol) were added to a 10 mL three-necked flask and stirred until complete dissolution. After cooling the reaction mixture to 0 °C, an aqueous solution of NaClO2 (124 mg, 1.38 mmol) was slowly added. Subsequently, 1 mL of HCl (117 μL) was added and stirred for 0.5 h at 0 °C. The reaction system was warmed up to 80 °C and stirring was continued for 0.5 hours. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature. The reaction mixture was dried with acetonitrile, the pH was adjusted to 2 with 1N HCl aqueous solution and then the organic phase was separated by extraction with ethyl acetate and water. The organic phase was dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the organic solvent to give the crude product. The crude product was purified by column chromatography using petroleum ether and ethyl acetate (1:1, v/v) as eluents, and concentrated under reduced pressure (5 torr) to give compound 32 as a white solid (50 mg, 46.6% yield).
References
[1] Patent: CN107556289, 2018, A. Location in patent: Paragraph 0142; 0144; 0145; 0146
2-Chloro-4-methylsulphonylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-4-methylsulphonylbenzoic acid Suppliers
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View Lastest Price from 2-Chloro-4-methylsulphonylbenzoic acid manufacturers
- Product
- 2-Chloro-4-methylsulphonylbenzoic acid 53250-83-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-03
- Product
- 2-Chloro-4-methylsulphonylbenzoic acid 53250-83-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 2-Chloro-4-methylsulphonylbenzoic acid 53250-83-2
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-15