(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL

Product Name: (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL
CAS No.: 161511-85-9
Chemical Name: (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL
Synonyms: (S)-1-(Tert-Butoxycarbon;(S)-1-Boc-2-azetidinemeth...;(S)-1-BOC-2-AZETIDINEMETHANOL;(S)-1-Boc-azetidine-2-methanol;(S)-1-Boc-2-hydroxyMethylazetidine;(S)-1-Boc-2-azetidinemethanol - [B1337];(S)-N-TERT-BUTOXYCARBONYL-2-AZETIDINYLMETHANOL;(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHAOL;(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL;(S)-N-TERT-BUTYLOXYCARBONYL-2-AZETIDINYLMETHANOL
CBNumber: CB1726301
Molecular Formula: C9H17NO3
Formula Weight: 187.24
MOL File: 161511-85-9.mol

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(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL Property

Boiling point:: 270.3±13.0 °C(Predicted)
Density: 1.05
refractive index: -74 ° (C=1, MeOH)
storage temp.: 2-8°C
form: clear liquid
pka: 14.77±0.10(Predicted)
color: Colorless to Light yellow
CAS DataBase Reference: 161511-85-9(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B2123
Product name: (S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol
Purity: >95.0%(GC)
Packaging: 1g
Price: $1412
Updated: 2025/07/31

TCI Chemical

Product number: B2123
Product name: (S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol
Purity: >95.0%(GC)
Packaging: 100mg
Price: $236
Updated: 2025/07/31

TRC

Product number: B809835
Product name: (S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol
Packaging: 2.5g
Price: $425
Updated: 2021/12/16

Activate Scientific

Product number: AS12114
Product name: (S)-1-Boc-2-azetidinemethanol
Purity: 97% ee
Packaging: 5G
Price: $486
Updated: 2021/12/16

Chem-Impex

Product number: 41646
Product name: (S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol,98%(Chiralpurity)
Purity: 98%(Chiralpurity)
Packaging: 1G
Price: $630.56
Updated: 2021/12/16

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(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL Chemical Properties,Usage,Production

Uses

(S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol is used for synthesis and the study of nicotinic receptor binding of PET ligand [18F]fluoroazetidinylmethoxypyridine.

Synthesis

51077-14-6

161511-85-9

The general procedure for the synthesis of (S)-1-(tert-butoxycarbonyl)-2-acridinemethanol from 1-Boc-L-acridine-2-carboxylic acid was as follows:Example 16 Synthesis of tert-butyl (S)-2-(hydroxymethyl)azetidine-1-carboxylate (14). To a solution of 13 (0.94 g, 4.7 mmol) in tetrahydrofuran (THF, 10 mL) was slowly added a THF solution (21.0 mL) of 1 M borane (BH3) at 0 °C. The reaction mixture was stirred at room temperature for 2 days. Subsequently, the reaction was quenched by the addition of cold water (20 mL) at 0 °C. After removal of THF by evaporation under reduced pressure, 10% aqueous citric acid solution (15 mL) was added and extracted with ethyl acetate (50 mL × 2). The combined ethyl acetate layers were washed sequentially with saturated sodium bicarbonate (NaHCO3, 30 mL) and sodium chloride (NaCl, 30 mL) aqueous solutions and dried over anhydrous sodium sulfate (Na2SO4). Ethyl acetate was removed by evaporation under reduced pressure to give 0.86 g (100% yield) of 14 as a colorless oil.1H NMR (300 MHz, CDCl3) δ 4.40 (m, 1H), 3.85-3.70 (m, 3H), 2.13 (m, 1H), 1.90 (m, 1H), 1.42 (s, 9H).

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 24, p. 7637 - 7647
[2] Patent: US2009/68105, 2009, A1. Location in patent: Page/Page column 11
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 4, p. 817 - 825
[4] Angewandte Chemie - International Edition, 2013, vol. 52, # 30, p. 7829 - 7832
[5] Angew. Chem., 2013, vol. 125, # 30, p. 7983 - 7986,4

(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL manufacturers

Career Henan Chemical Co

Product: (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 161511-85-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-03

161511-85-9, (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOLRelated Search:

D-GLUCAMINE (R)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL (2S)-2-[[[5-(TRIMETHYLSTANNYL)-3-PYRIDINYL]OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID, T-BUTYL ESTER (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 1-AZETIDINECARBOXYLIC ACID, 2-[[[2-NITRO-3-PYRIDINYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER, (2S)- (3-[2(S)-N-(TERT-BUTOXYCARBONYL)-2-AZETIDINYL-METHOXY]PYRIDIN-2-YL)TRIMETHYLAMMONIUM TRIFLUOROMETHANESULFONATE 2-IODO-3-(1-TERT-BUTOXYCARBONYL-2-(S)-AZETIDINYLMETHOXY)PYRIDINE 1-Boc-L-azetidine-2-carboxylic acid (S)-N-BOC-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER

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(S)-N-TERT-BUTOXYCARBONYL-2-AZETIDINYLMETHANOL

(S)-1-BOC-2-AZETIDINEMETHANOL

(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL

(S)-1-(Tert-Butoxycarbon

(S)-tert-butyl 2-(hydroxymethyl)azetidine-1-carboxylate

(S)-2-Hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester

(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHAOL

(S)-1-Boc-2-azetidinemeth...

(S)-1-Boc-2-hydroxyMethylazetidine

(<i>S</i>)-1-(<i>tert</i>-Butoxycarbonyl)-2-azetidineMethanol

tert-Butyl (2S)-2-(hydroxymethyl)-1-azetidinecarboxylate

(S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol &gt

1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S)-

(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL ISO 9001：2015 REACH

(S)-1-Boc-azetidine-2-methanol

(S)-1-Boc-2-azetidinemethanol - [B1337]

161511-85-9

Glycidyl Compounds, etc. (Chiral)

Azetidines

Simple 4-Membered Ring Compounds

Chiral Building Blocks

Heterocycle-other series

Azetidines

Chiral Building Blocks

Glycidyl Compounds, etc. (Chiral)

Simple 4-Membered Ring Compounds

Synthetic Organic Chemistry