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(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL

Product Name
(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL
CAS No.
161511-85-9
Chemical Name
(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL
Synonyms
(S)-1-(Tert-Butoxycarbon;(S)-1-Boc-2-azetidinemeth...;(S)-1-BOC-2-AZETIDINEMETHANOL;(S)-1-Boc-azetidine-2-methanol;(S)-1-Boc-2-hydroxyMethylazetidine;(S)-1-Boc-2-azetidinemethanol - [B1337];(S)-N-TERT-BUTOXYCARBONYL-2-AZETIDINYLMETHANOL;(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHAOL;(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL;(S)-N-TERT-BUTYLOXYCARBONYL-2-AZETIDINYLMETHANOL
CBNumber
CB1726301
Molecular Formula
C9H17NO3
Formula Weight
187.24
MOL File
161511-85-9.mol
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(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL Property

Boiling point:
270.3±13.0 °C(Predicted)
Density 
1.05
refractive index 
-74 ° (C=1, MeOH)
storage temp. 
2-8°C
form 
clear liquid
pka
14.77±0.10(Predicted)
color 
Colorless to Light yellow
CAS DataBase Reference
161511-85-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN2811
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B2123
Product name
(S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol
Purity
>95.0%(GC)
Packaging
1g
Price
$1412
Updated
2025/07/31
TCI Chemical
Product number
B2123
Product name
(S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol
Purity
>95.0%(GC)
Packaging
100mg
Price
$236
Updated
2025/07/31
TRC
Product number
B809835
Product name
(S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol
Packaging
2.5g
Price
$425
Updated
2021/12/16
Activate Scientific
Product number
AS12114
Product name
(S)-1-Boc-2-azetidinemethanol
Purity
97% ee
Packaging
5G
Price
$486
Updated
2021/12/16
Chem-Impex
Product number
41646
Product name
(S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol,98%(Chiralpurity)
Purity
98%(Chiralpurity)
Packaging
1G
Price
$630.56
Updated
2021/12/16
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(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL Chemical Properties,Usage,Production

Uses

(S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol is used for synthesis and the study of nicotinic receptor binding of PET ligand [18F]fluoroazetidinylmethoxypyridine.

Synthesis

51077-14-6

161511-85-9

The general procedure for the synthesis of (S)-1-(tert-butoxycarbonyl)-2-acridinemethanol from 1-Boc-L-acridine-2-carboxylic acid was as follows:Example 16 Synthesis of tert-butyl (S)-2-(hydroxymethyl)azetidine-1-carboxylate (14). To a solution of 13 (0.94 g, 4.7 mmol) in tetrahydrofuran (THF, 10 mL) was slowly added a THF solution (21.0 mL) of 1 M borane (BH3) at 0 °C. The reaction mixture was stirred at room temperature for 2 days. Subsequently, the reaction was quenched by the addition of cold water (20 mL) at 0 °C. After removal of THF by evaporation under reduced pressure, 10% aqueous citric acid solution (15 mL) was added and extracted with ethyl acetate (50 mL × 2). The combined ethyl acetate layers were washed sequentially with saturated sodium bicarbonate (NaHCO3, 30 mL) and sodium chloride (NaCl, 30 mL) aqueous solutions and dried over anhydrous sodium sulfate (Na2SO4). Ethyl acetate was removed by evaporation under reduced pressure to give 0.86 g (100% yield) of 14 as a colorless oil.1H NMR (300 MHz, CDCl3) δ 4.40 (m, 1H), 3.85-3.70 (m, 3H), 2.13 (m, 1H), 1.90 (m, 1H), 1.42 (s, 9H).

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 24, p. 7637 - 7647
[2] Patent: US2009/68105, 2009, A1. Location in patent: Page/Page column 11
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 4, p. 817 - 825
[4] Angewandte Chemie - International Edition, 2013, vol. 52, # 30, p. 7829 - 7832
[5] Angew. Chem., 2013, vol. 125, # 30, p. 7983 - 7986,4

(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL Suppliers

Americas 1 China 105 Europe 1 Germany 2 India 2 Japan 2 United Kingdom 4 United States 20 Global 137
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL manufacturers

Career Henan Chemical Co
Product
(S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 161511-85-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-03

161511-85-9, (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOLRelated Search:

D-GLUCAMINE (R)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL (2S)-2-[[[5-(TRIMETHYLSTANNYL)-3-PYRIDINYL]OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID, T-BUTYL ESTER (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL 1-AZETIDINECARBOXYLIC ACID, 2-[[[2-NITRO-3-PYRIDINYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER, (2S)- (3-[2(S)-N-(TERT-BUTOXYCARBONYL)-2-AZETIDINYL-METHOXY]PYRIDIN-2-YL)TRIMETHYLAMMONIUM TRIFLUOROMETHANESULFONATE 2-IODO-3-(1-TERT-BUTOXYCARBONYL-2-(S)-AZETIDINYLMETHOXY)PYRIDINE 1-Boc-L-azetidine-2-carboxylic acid (S)-N-BOC-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER

  • TERT-BUTYL (2S)-2-(HYDROXYMETHYL)AZETIDINE-1-CARBOXYLATE
  • (S)-N-TERT-BUTYLOXYCARBONYL-2-AZETIDINYLMETHANOL
  • (S)-N-TERT-BUTOXYCARBONYL-2-AZETIDINYLMETHANOL
  • (S)-1-BOC-2-AZETIDINEMETHANOL
  • (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL
  • (S)-1-(Tert-Butoxycarbon
  • (S)-tert-butyl 2-(hydroxymethyl)azetidine-1-carboxylate
  • (S)-2-Hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester
  • (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHAOL
  • (S)-1-Boc-2-azetidinemeth...
  • (S)-1-Boc-2-hydroxyMethylazetidine
  • (<i>S</i>)-1-(<i>tert</i>-Butoxycarbonyl)-2-azetidineMethanol
  • tert-Butyl (2S)-2-(hydroxymethyl)-1-azetidinecarboxylate
  • (S)-1-(tert-Butoxycarbonyl)-2-azetidinemethanol &gt
  • 1-Azetidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S)-
  • (S)-1-(TERT-BUTOXYCARBONYL)-2-AZETIDINEMETHANOL ISO 9001：2015 REACH
  • (S)-1-Boc-azetidine-2-methanol
  • (S)-1-Boc-2-azetidinemethanol - [B1337]
  • 161511-85-9
  • Glycidyl Compounds, etc. (Chiral)
  • Azetidines
  • Simple 4-Membered Ring Compounds
  • Chiral Building Blocks
  • Heterocycle-other series
  • Azetidines
  • Chiral Building Blocks
  • Glycidyl Compounds, etc. (Chiral)
  • Simple 4-Membered Ring Compounds
  • Synthetic Organic Chemistry