1-Boc-L-azetidine-2-carboxylic acid
- Product Name
- 1-Boc-L-azetidine-2-carboxylic acid
- CAS No.
- 51077-14-6
- Chemical Name
- 1-Boc-L-azetidine-2-carboxylic acid
- Synonyms
- Boc-Aze-OH;BOC-AZE(2)-OH;RARECHEM EM WB 0077;-azetidine-2-carboxyL;BOC-AZETIDINE-2-CARBOXYLIC ACID;BOC-L-AZETIDINE-2-CARBOXYLIC ACID;N-Boc-S-2-Azetidinecarboxylic acid;(S)-N-BOC-AZETIDINE CARBOXYLIC ACID;N-Boc-L-azetidine-2-carboxylic Acid;1-BOC-L-AZETIDINE-2-CARBOXYLIC ACID
- CBNumber
- CB3349391
- Molecular Formula
- C9H15NO4
- Formula Weight
- 201.22
- MOL File
- 51077-14-6.mol
1-Boc-L-azetidine-2-carboxylic acid Property
- Melting point:
- 105-110 °C
- Boiling point:
- 339.14°C (rough estimate)
- Density
- 1.2250 (rough estimate)
- refractive index
- 1.4640 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Dichloromethane, DMSO, Ethyl Acetate, Methanol
- pka
- 4.01±0.20(Predicted)
- form
- Solid
- color
- White
- optical activity
- [α]/D -120.0±2.0°, c = 1 in methanol
- InChI
- InChI=1S/C9H15NO4/c1-9(2,3)14-8(13)10-5-4-6(10)7(11)12/h6H,4-5H2,1-3H3,(H,11,12)/t6-/m0/s1
- InChIKey
- JWJVSDZKYYXDDN-LURJTMIESA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC[C@H]1C(O)=O
- CAS DataBase Reference
- 51077-14-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B6343
- Product name
- (S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic Acid
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $115
- Updated
- 2025/07/31
- Product number
- B624500
- Product name
- N-Boc-L-azetidine-2-carboxylicAcid
- Packaging
- 2g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 07328
- Product name
- Boc-L-azetidine-2-carboxylic acid
- Purity
- ≥ 99.95% (Chiral HPLC)
- Packaging
- 1G
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 042027
- Product name
- Boc-(S)-azetidine-2-carboxylic acid
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- JK424248
- Product name
- 1-Boc-L-azetidine-2-carboxylic acid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
1-Boc-L-azetidine-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
Protected Azetidine derivative.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
2133-34-8
51077-14-6
The general procedure for the synthesis of 1-Boc-L-acridine-2-carboxylic acid from di-tert-butyl dicarbonate and (S)-2-carboxycyclobutanamine was as follows:Example 15: (S)-1-(tert-butoxycarbonyl)azetidine-2-carboxylic acid (13). NaOH (420 mg, 10.5 mmol) was slowly added to a mixed solution of ethanol (20 mL) and water (10 mL) of (S)-2-azetidinecarboxylic acid 12 (1.0 g, 10.0 mmol) and di-tert-butyl dicarbonate (2.83 g, 12.5 mmol) at 0 °C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the ethanol was removed by evaporation and diluted by adding water (20 mL), followed by adjusting the pH with dilute HCl to 3. Extraction was carried out with ethyl acetate (50 mL x 3) and the organic phases were combined. The organic phase was washed sequentially with water (30 mL) and saturated NaCl solution (30 mL) and then dried with Na2SO4. Evaporation to remove the ethyl acetate gave 1.98 g (100% yield) of target product 13 as a white solid.1H NMR (300 MHz, CDCl3) δ 4.79 (m, 1H), 3.93 (m, 2H), 2.46 (m, 2H), 1.48 (s, 9H).
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 24, p. 7637 - 7647
[2] Patent: US2009/68105, 2009, A1. Location in patent: Page/Page column 11
[3] Chemical Communications, 2016, vol. 52, # 7, p. 1354 - 1357
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 1998, vol. 41, # 5, p. 451 - 463
[5] Journal of Medicinal Chemistry, 1999, vol. 42, # 12, p. 2251 - 2259
1-Boc-L-azetidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-L-azetidine-2-carboxylic acid manufacturers
- Product
- 1-Boc-L-azetidine-2-carboxylic acid 51077-14-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-03-05
- Product
- 1-Boc-L-azetidine-2-carboxylic acid 51077-14-6
- Price
- US $3.00/KG
- Min. Order
- 3KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-08-26