2-ETHOXY-6,9-DIAMINOACRIDINE
- Product Name
- 2-ETHOXY-6,9-DIAMINOACRIDINE
- CAS No.
- 442-16-0
- Chemical Name
- 2-ETHOXY-6,9-DIAMINOACRIDINE
- Synonyms
- RIVANOL;ACRINOL;Etakridin;Ethacridine;Ethacrindine;2-Ethoxy-6,9-acridinediamine;7-Ethoxy-3,9-acridinediamine;6,9-DIAMINO-2-ETHOXYACRIDINE;2-ETHOXY-6,9-DIAMINOACRIDINE;7-ETHOXY-ACRIDINE-3,9-DIAMINE
- CBNumber
- CB4116840
- Molecular Formula
- C15H15N3O
- Formula Weight
- 253.3
- MOL File
- 442-16-0.mol
2-ETHOXY-6,9-DIAMINOACRIDINE Property
- Melting point:
- 226°
- Boiling point:
- 396.5°C (rough estimate)
- Density
- 1.0966 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- 2-8°C
- pka
- 11.22±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E676543
- Product name
- 7-Ethoxyacridine-3,9-diamine
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- H779
- Product name
- 7-Ethoxyacridine-3,9-diamine
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- API0015644
- Product name
- ETHACRIDINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $462
- Updated
- 2021/12/16
- Product number
- H779
- Product name
- 7-Ethoxyacridine-3,9-diamine
- Packaging
- 1g
- Price
- $489
- Updated
- 2021/12/16
- Product number
- 442160
- Product name
- 7-Ethoxyacridine-3,9-diamine
- Packaging
- 5g
- Price
- $508.8
- Updated
- 2021/12/16
2-ETHOXY-6,9-DIAMINOACRIDINE Chemical Properties,Usage,Production
Originator
Rivanol,Sopharma
Uses
7-ethoxyacridine-3,9-diamine is used in biological studies for cancer regression by inducing a regeneration-like response by activating expression and/or function of YAP and/or TAZ.
Definition
ChEBI: Ethacridine is a member of acridines.
Manufacturing Process
A mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6-
nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of
30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous
oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by
weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C.
Subsequently, the whole was cooled to 100°C, the reaction mixture was
introduced into 1000 parts by volume of water, rendered acidic to Congo
paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine
precipitated was filtered off. By reduction iron according to Bechamp, 6,9-
diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as
the yellow needles. The base was prepared by adding an equivalent of NaOH.
MP: 124°C.
In practice it is usually used as lactate.
Therapeutic Function
Antiseptic, Antibacterial
Purification Methods
It crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]
2-ETHOXY-6,9-DIAMINOACRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-ETHOXY-6,9-DIAMINOACRIDINE manufacturers
- Product
- Ethacridine 442-16-0
- Price
- US $80.00/KG
- Min. Order
- 1KG
- Purity
- >99%
- Supply Ability
- 20tons
- Release date
- 2023-03-14
- Product
- 2-ETHOXY-6,9-DIAMINOACRIDINE 442-16-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-22
- Product
- Ethacridine Lactate 442-16-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 600 Tons
- Release date
- 2020-05-03