ChemicalBook > CAS DataBase List > 2-ETHOXY-6,9-DIAMINOACRIDINE

2-ETHOXY-6,9-DIAMINOACRIDINE

Product Name
2-ETHOXY-6,9-DIAMINOACRIDINE
CAS No.
442-16-0
Chemical Name
2-ETHOXY-6,9-DIAMINOACRIDINE
Synonyms
RIVANOL;ACRINOL;Etakridin;Ethacridine;Ethacrindine;2-Ethoxy-6,9-acridinediamine;7-Ethoxy-3,9-acridinediamine;6,9-DIAMINO-2-ETHOXYACRIDINE;2-ETHOXY-6,9-DIAMINOACRIDINE;7-ETHOXY-ACRIDINE-3,9-DIAMINE
CBNumber
CB4116840
Molecular Formula
C15H15N3O
Formula Weight
253.3
MOL File
442-16-0.mol
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2-ETHOXY-6,9-DIAMINOACRIDINE Property

Melting point:
226°
Boiling point:
396.5°C (rough estimate)
Density 
1.0966 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
2-8°C
pka
11.22±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
E676543
Product name
7-Ethoxyacridine-3,9-diamine
Packaging
50mg
Price
$250
Updated
2021/12/16
AK Scientific
Product number
H779
Product name
7-Ethoxyacridine-3,9-diamine
Packaging
250mg
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015644
Product name
ETHACRIDINE
Purity
95.00%
Packaging
250MG
Price
$462
Updated
2021/12/16
AK Scientific
Product number
H779
Product name
7-Ethoxyacridine-3,9-diamine
Packaging
1g
Price
$489
Updated
2021/12/16
AHH
Product number
API-1005
Product name
Acrinol
Purity
98%
Packaging
1000g
Price
$260
Updated
2021/12/16
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2-ETHOXY-6,9-DIAMINOACRIDINE Chemical Properties,Usage,Production

Originator

Rivanol,Sopharma

Uses

7-ethoxyacridine-3,9-diamine is used in biological studies for cancer regression by inducing a regeneration-like response by activating expression and/or function of YAP and/or TAZ.

Definition

ChEBI: Ethacridine is a member of acridines.

Manufacturing Process

A mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6- nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of 30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C. Subsequently, the whole was cooled to 100°C, the reaction mixture was introduced into 1000 parts by volume of water, rendered acidic to Congo paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine precipitated was filtered off. By reduction iron according to Bechamp, 6,9- diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as the yellow needles. The base was prepared by adding an equivalent of NaOH. MP: 124°C.
In practice it is usually used as lactate.

Therapeutic Function

Antiseptic, Antibacterial

Purification Methods

It crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]

2-ETHOXY-6,9-DIAMINOACRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ETHOXY-6,9-DIAMINOACRIDINE Suppliers

Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 2-ETHOXY-6,9-DIAMINOACRIDINE manufacturers

Weijer International Trade (Hebei) Co., Ltd
Product
Ethacridine 442-16-0
Price
US $80.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
20tons
Release date
2023-03-14
Dideu Industries Group Limited
Product
2-ETHOXY-6,9-DIAMINOACRIDINE 442-16-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-22
Shaanxi Dideu Medichem Co. Ltd
Product
Ethacridine Lactate 442-16-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
600 Tons
Release date
2020-05-03

442-16-0, 2-ETHOXY-6,9-DIAMINOACRIDINERelated Search:


  • 2-ETHOXY-6,9-DIAMINOACRIDINE
  • 6,9-DIAMINO-2-ETHOXYACRIDINE
  • 7-ETHOXY-ACRIDINE-3,9-DIAMINE
  • ACRINOL
  • RIVANOL
  • Ethacridine
  • 6,9-DIAMINO-2-ETHOXYACRIDINEHYDROCHLORIDE
  • 7-Ethoxy-3,9-acridinediamine
  • 2-Ethoxy-6,9-acridinediamine
  • Etakridin
  • Ethacrindine
  • 3,9-Acridinediamine, 7-ethoxy-
  • 2-ETHOXY-6,9-DIAMINOACRIDINE USP/EP/BP
  • 442-16-0
  • 440-16-0