2-ETHOXY-6,9-DIAMINOACRIDINE

Product Name: 2-ETHOXY-6,9-DIAMINOACRIDINE
CAS No.: 442-16-0
Chemical Name: 2-ETHOXY-6,9-DIAMINOACRIDINE
Synonyms: RIVANOL;ACRINOL;Etakridin;Ethacridine;Ethacrindine;2-Ethoxy-6,9-acridinediamine;7-Ethoxy-3,9-acridinediamine;6,9-DIAMINO-2-ETHOXYACRIDINE;2-ETHOXY-6,9-DIAMINOACRIDINE;7-ETHOXY-ACRIDINE-3,9-DIAMINE
CBNumber: CB4116840
Molecular Formula: C15H15N3O
Formula Weight: 253.3
MOL File: 442-16-0.mol

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2-ETHOXY-6,9-DIAMINOACRIDINE Property

Melting point:: 226°
Boiling point:: 396.5°C (rough estimate)
Density: 1.0966 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: 2-8°C
pka: 11.22±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E676543
Product name: 7-Ethoxyacridine-3,9-diamine
Packaging: 50mg
Price: $250
Updated: 2021/12/16

AK Scientific

Product number: H779
Product name: 7-Ethoxyacridine-3,9-diamine
Packaging: 250mg
Price: $195
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015644
Product name: ETHACRIDINE
Purity: 95.00%
Packaging: 250MG
Price: $462
Updated: 2021/12/16

AK Scientific

Product number: H779
Product name: 7-Ethoxyacridine-3,9-diamine
Packaging: 1g
Price: $489
Updated: 2021/12/16

AHH

Product number: API-1005
Product name: Acrinol
Purity: 98%
Packaging: 1000g
Price: $260
Updated: 2021/12/16

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2-ETHOXY-6,9-DIAMINOACRIDINE Chemical Properties,Usage,Production

Chemical Properties

Orange-yellow crystal. Melting point 226°C. Commonly used as its lactate (C15H15N3O-C3H6O3) = 343.38, [1837-57-6], called Rivanol. The lactate is a pale yellow crystal with a melting point of 253°C (226°F). It is soluble in 9 parts boiling water, 15 parts cold water, and 110 parts ethanol at 22 °C. The aqueous solution is fluorescent yellow.

Originator

Rivanol,Sopharma

Uses

7-ethoxyacridine-3,9-diamine is used in biological studies for cancer regression by inducing a regeneration-like response by activating expression and/or function of YAP and/or TAZ.

Definition

ChEBI: Ethacridine is a member of acridines.

Manufacturing Process

A mixture of 250 parts by volume of ethylene glycol, 50 parts by weight of 6- nitro-9-chloro-2-ethoxyacridine (obtained by reaction of 52 parts by weight of 30 nitro-4-ethoxy-diphenylamine-6-carboxylic acid with phosphorous oxychloride), 10 parts by weight of ammonium chloride, and 11 parts by weight of urea were heated to 170°C and stirred for 1 hour at 170°-175°C. Subsequently, the whole was cooled to 100°C, the reaction mixture was introduced into 1000 parts by volume of water, rendered acidic to Congo paper by means of hydrochloric acid and the 6-nitro-9-amino-2-ethoxyacridine precipitated was filtered off. By reduction iron according to Bechamp, 6,9- diamino-2-ethoxy-acridine hydrochloride was obtained with yield of 83% as the yellow needles. The base was prepared by adding an equivalent of NaOH. MP: 124°C.
In practice it is usually used as lactate.

Therapeutic Function

Antiseptic, Antibacterial

Purification Methods

It crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]

2-ETHOXY-6,9-DIAMINOACRIDINE Preparation Products And Raw materials

Raw materials

2-Chloro-4-nitrobenzoic acid Ethacridine lactate monohydrate

Preparation Products

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2-ETHOXY-6,9-DIAMINOACRIDINE Suppliers

China 22 Germany 1 India 1 Japan 1 United Kingdom 2 United States 11 Global 38

Shanghai T&W Pharmaceutical Co., Ltd.

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View Lastest Price from 2-ETHOXY-6,9-DIAMINOACRIDINE manufacturers

Weijer International Trade (Hebei) Co., Ltd

Product: Ethacridine 442-16-0
Price: US $80.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 20tons
Release date: 2023-03-14

Dideu Industries Group Limited

Product: 2-ETHOXY-6,9-DIAMINOACRIDINE 442-16-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-22

Shaanxi Dideu Medichem Co. Ltd

Product: Ethacridine Lactate 442-16-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 600 Tons
Release date: 2020-05-03

442-16-0, 2-ETHOXY-6,9-DIAMINOACRIDINERelated Search:

Acridine Calamine lotion 2-ETHOXY-6,9-DIAMINOACRIDINE LACTATE,2-ETHOXY-6,9-DIAMINOACRIDINE LACTATE MONHYDRATE,2-ETHOXY-6,9-DIAMINOACRIDINE LACTATE MONOHYDRATE 2-ETHOXY-6,9-DIAMINOACRIDINE LACTATE AURORA KA-4311 2-ETHOXY-6-NITRO-ACRIDIN-9-YLAMINE 2-ETHOXY-6,9-DIAMINOACRIDINE

2-ETHOXY-6,9-DIAMINOACRIDINE

6,9-DIAMINO-2-ETHOXYACRIDINE

7-ETHOXY-ACRIDINE-3,9-DIAMINE

ACRINOL

RIVANOL

Ethacridine

6,9-DIAMINO-2-ETHOXYACRIDINEHYDROCHLORIDE

7-Ethoxy-3,9-acridinediamine

2-Ethoxy-6,9-acridinediamine

Etakridin

Ethacrindine

3,9-Acridinediamine, 7-ethoxy-

2-ETHOXY-6,9-DIAMINOACRIDINE USP/EP/BP

442-16-0

440-16-0