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Amsacrine hydrochloride

Product Name
Amsacrine hydrochloride
CAS No.
54301-15-4
Chemical Name
Amsacrine hydrochloride
Synonyms
nsc141549;nci-c03190;M-AMSA, HCL;M-Amsacrine;META-AMSACRINE;AMSA hydrochloride;M-AMSA HYDROCHLORIDE;AMSACRINE HYDROCHLORIDE;acridinyl anisidide hydrochloride;AMine hydrochloride benzene acridine
CBNumber
CB4236395
Molecular Formula
C21H20ClN3O3S
Formula Weight
429.92
MOL File
54301-15-4.mol
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Amsacrine hydrochloride Property

Melting point:
197-199 °C(lit.)
storage temp. 
Refrigerator
solubility 
DMSO: 10 mg/mL with heat and sonication
form 
powder
color 
red to brown
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
PB1081000
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9809
Product name
Amsacrine hydrochloride
Purity
≥98% (TLC), powder
Packaging
10mg
Price
$328
Updated
2023/01/07
Sigma-Aldrich
Product number
A9809
Product name
Amsacrine hydrochloride
Purity
≥98% (TLC), powder
Packaging
50mg
Price
$1190
Updated
2023/01/07
TCI Chemical
Product number
A2777
Product name
Amsacrine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$147
Updated
2023/01/07
TCI Chemical
Product number
A2777
Product name
Amsacrine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$436
Updated
2023/01/07
Cayman Chemical
Product number
22223
Product name
Amsacrine (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2023/01/06
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Amsacrine hydrochloride Chemical Properties,Usage,Production

Uses

Amsacrine hydrochloride has been used:

  • as a topoisomerase poison in bacteriophage T4 topoisomerase assay
  • as a topoisomerase inhibitor in Drosophila cell line, Kc167
  • as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
  • as a topoisomerase II poison in dose-response assays in C elegans

Biological Activity

amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].

Biochem/physiol Actions

Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.

References

[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.

Amsacrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Amsacrine hydrochloride Suppliers

Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6002
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24540
Advantage
81
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9559
Advantage
66
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28400
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23682
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23664
Advantage
75
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-62063333-1 15601730970
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24968
Advantage
65
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7937
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9988
Advantage
55
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View Lastest Price from Amsacrine hydrochloride manufacturers

Career Henan Chemical Co
Product
Amsacrine hydrochloride 54301-15-4
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-09

54301-15-4, Amsacrine hydrochlorideRelated Search:


  • m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride
  • Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride
  • Methanesulfon-m-anisidide 4'-(9-acridinylamino)-
  • Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride
  • 4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE
  • M-AMSA HYDROCHLORIDE
  • M-AMSA, HCL
  • Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride
  • M-Amsacrine
  • META-AMSACRINE
  • N-(4-(acridin-9-ylaMino)-3-Methoxyphenyl)MethanesulfonaMide hydrochloride
  • MethanesulfonaMide,N-[4-(9-acridinylaMino)-3-Methoxyphenyl]-, hydrochloride (1:1)
  • AMine hydrochloride benzene acridine
  • AMSACRINE HYDROCHLORIDE
  • nsc141549
  • AMSA hydrochloride
  • Amsacrine Hydrochloride, 4-(9-Acridinylamino)-N-(Methanesulfonyl)-M-Anisidine Hydrochloride
  • Amsacrine hydrochloride, ≥98% (HPLC)
  • 4’-((9-acridinyl)amino)-methanesulfon-m-anisidinhydrochloride
  • 4’-(9-acridinylamino)methanesulfon-m-anisidemonohydrochloride
  • 4’-(9-acridinylamino)-methanesulfon-m-anisididmonohydrochloride
  • 4’-(9-acridinylamino)-methanesulfonyl-m-anisidinmonohydrochloride
  • n-(4-(9-acridinylamino)-3-methoxyphenyl)-methanesulfonamidmonohydrochlor
  • nci-c03190
  • acridinyl anisidide hydrochloride
  • 54301-15-4
  • C21H19N3O3S
  • C21H19N3O3SHCl
  • Apoptosis and Cell Cycle
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • DNA metabolism
  • DNA Repair Regulators