Amsacrine hydrochloride

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Amsacrine hydrochloride

Product Name: Amsacrine hydrochloride
CAS No.: 54301-15-4
Chemical Name: Amsacrine hydrochloride
Synonyms: nsc141549;nci-c03190;M-AMSA, HCL;M-Amsacrine;Amsacrine HCI;META-AMSACRINE;AMSA hydrochloride;M-AMSA HYDROCHLORIDE;AMSACRINE HYDROCHLORIDE;acridinyl anisidide hydrochloride
CBNumber: CB4236395
Molecular Formula: C21H20ClN3O3S
Formula Weight: 429.92
MOL File: 54301-15-4.mol

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Amsacrine hydrochloride Property

Melting point:: 197-199 °C(lit.)
storage temp.: Refrigerator
solubility: DMSO: 10 mg/mL with heat and sonication
form: powder
color: red to brown

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: PB1081000
HS Code: 2933.99.8290
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9809
Product name: Amsacrine hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 10mg
Price: $336
Updated: 2024/03/01

Sigma-Aldrich

Product number: A9809
Product name: Amsacrine hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 50mg
Price: $1220
Updated: 2024/03/01

TCI Chemical

Product number: A2777
Product name: Amsacrine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $118
Updated: 2024/03/01

TCI Chemical

Product number: A2777
Product name: Amsacrine Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $349
Updated: 2024/03/01

Cayman Chemical

Product number: 22223
Product name: Amsacrine (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

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Amsacrine hydrochloride Chemical Properties,Usage,Production

Uses

Amsacrine hydrochloride has been used:

as a topoisomerase poison in bacteriophage T4 topoisomerase assay
as a topoisomerase inhibitor in Drosophila cell line, Kc167
as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
as a topoisomerase II poison in dose-response assays in C elegans

Biological Activity

amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].

Biochem/physiol Actions

Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.

References

[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.

Amsacrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Amsacrine

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View Lastest Price from Amsacrine hydrochloride manufacturers

Career Henan Chemical Co

Product: Amsacrine hydrochloride 54301-15-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

54301-15-4, Amsacrine hydrochlorideRelated Search:

Methoxyammonium chloride Diphenhydramine Hydrochloride Basic Orange 14 Topotecan hydrochloride Benzhexol hydrochloride Quinacridone 2-ETHOXY-6,9-DIAMINOACRIDINE Dopamine hydrochloride Amiodarone hydrochloride 6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE 9(10H)-ACRIDONE anisidine M-ANISIDINE HYDROCHLORIDE Amsacrine/Amsacrine hydrochloride,Amsacrine/Amsacrine hydrochloride DL-Norephedrine hydrochloride Methanesulfonamide Amsacrine hydrochloride Amsacrine, HCl

m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride

Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride

Methanesulfon-m-anisidide 4'-(9-acridinylamino)-

Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride

4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE

M-AMSA HYDROCHLORIDE

M-AMSA, HCL

Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride

M-Amsacrine

META-AMSACRINE

N-(4-(acridin-9-ylaMino)-3-Methoxyphenyl)MethanesulfonaMide hydrochloride

MethanesulfonaMide,N-[4-(9-acridinylaMino)-3-Methoxyphenyl]-, hydrochloride (1:1)

AMine hydrochloride benzene acridine

AMSACRINE HYDROCHLORIDE

nsc141549

AMSA hydrochloride

Amsacrine Hydrochloride, 4-(9-Acridinylamino)-N-(Methanesulfonyl)-M-Anisidine Hydrochloride

Amsacrine hydrochloride, ≥98% (HPLC)

4’-((9-acridinyl)amino)-methanesulfon-m-anisidinhydrochloride

4’-(9-acridinylamino)methanesulfon-m-anisidemonohydrochloride

4’-(9-acridinylamino)-methanesulfon-m-anisididmonohydrochloride

4’-(9-acridinylamino)-methanesulfonyl-m-anisidinmonohydrochloride

n-(4-(9-acridinylamino)-3-methoxyphenyl)-methanesulfonamidmonohydrochlor

nci-c03190

acridinyl anisidide hydrochloride

Amsacrine HCI

54301-15-4

C21H19N3O3S

C21H19N3O3SHCl

Apoptosis and Cell Cycle

BioChemical

Cell Biology

Cell Signaling and Neuroscience

DNA metabolism

DNA Repair Regulators