Amsacrine hydrochloride
- Product Name
- Amsacrine hydrochloride
- CAS No.
- 54301-15-4
- Chemical Name
- Amsacrine hydrochloride
- Synonyms
- nsc141549;nci-c03190;M-AMSA, HCL;M-Amsacrine;Amsacrine HCI;META-AMSACRINE;AMSA hydrochloride;M-AMSA HYDROCHLORIDE;AMSACRINE HYDROCHLORIDE;acridinyl anisidide hydrochloride
- CBNumber
- CB4236395
- Molecular Formula
- C21H20ClN3O3S
- Formula Weight
- 429.92
- MOL File
- 54301-15-4.mol
Amsacrine hydrochloride Property
- Melting point:
- 197-199 °C(lit.)
- storage temp.
- Refrigerator
- solubility
- DMSO: 10 mg/mL with heat and sonication
- form
- powder
- color
- red to brown
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- PB1081000
- HS Code
- 2933.99.8290
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- A9809
- Product name
- Amsacrine hydrochloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 10mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- A9809
- Product name
- Amsacrine hydrochloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 50mg
- Price
- $1220
- Updated
- 2024/03/01
- Product number
- A2777
- Product name
- Amsacrine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 20mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- A2777
- Product name
- Amsacrine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $349
- Updated
- 2024/03/01
- Product number
- 22223
- Product name
- Amsacrine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
Amsacrine hydrochloride Chemical Properties,Usage,Production
Uses
Amsacrine hydrochloride has been used:
- as a topoisomerase poison in bacteriophage T4 topoisomerase assay
- as a topoisomerase inhibitor in Drosophila cell line, Kc167
- as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
- as a topoisomerase II poison in dose-response assays in C elegans
Biological Activity
amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].
Biochem/physiol Actions
Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.
References
[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.
Amsacrine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Amsacrine hydrochloride Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from Amsacrine hydrochloride manufacturers
- Product
- Amsacrine hydrochloride 54301-15-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09