3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER
- Product Name
- 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER
- CAS No.
- 33166-79-9
- Chemical Name
- 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER
- Synonyms
- Ethyl m-toluoylacetate;Ethyl m-methylbenzoylacetate;ETHYL (3-METHYLBENZOYL)ACETATE;ETHYL 3-OXO-3-M-TOLYLPROPANOATE;Ethyl 2-(3-methylbenzoyl)acetate;Ethyl 3-oxo-3-(m-tolyl)propionate;2-[(3-methylphenyl)-oxomethyl]butanoate;ETHYL 3-(3-METHYLPHENYL)-3-OXOPROPANOATE;3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER;3-OXO-3-(3-TOLYL)PROPIONIC ACID ETHYL ESTER
- CBNumber
- CB1732689
- Molecular Formula
- C12H14O3
- Formula Weight
- 206.24
- MOL File
- 33166-79-9.mol
3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER Property
- Boiling point:
- 273-274 °C(lit.)
- Density
- 1.083 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5290(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 33166-79-9(CAS DataBase Reference)
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 559180
- Product name
- Ethyl (3-methylbenzoyl)acetate
- Packaging
- 1g
- Price
- $113.05
- Updated
- 2025/07/31
- Product number
- E926713
- Product name
- Ethyl3-Oxo-3-(m-tolyl)propanoate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B825
- Product name
- Ethyl (3-methylbenzoyl)acetate
- Packaging
- 5g
- Price
- $253
- Updated
- 2021/12/16
- Product number
- 079830
- Product name
- Ethyl 3-(3-methylphenyl)-3-oxopropanoate
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 079830
- Product name
- Ethyl 3-(3-methylphenyl)-3-oxopropanoate
- Packaging
- 5g
- Price
- $452
- Updated
- 2021/12/16
3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Reactant for:• ;Stereoselective ketonization-olefination of indoles by Co/Mn-mediated oxidative cross-coupling of indoles via dioxygen activation1• ;Enantioselective Michael reaction2• ;SEGPhos-ruthenium-catalyzed asymmetric hydrogenation3
Uses
Reactant for:
- Stereoselective ketonization-olefination of indoles by Co/Mn-mediated oxidative cross-coupling of indoles via dioxygen activation
- Enantioselective Michael reaction
- SEGPhos-ruthenium-catalyzed asymmetric hydrogenation
Synthesis
105-58-8
585-74-0
33166-79-9
GENERAL STEPS: In a dry reaction flask, sodium hydride (3.1 g, 77.1 mmol) was suspended in diethyl carbonate, followed by the slow addition of 3'-methylacetophenone (4.5 g, 33.54 mmol). The reaction mixture was heated at 80 °C and stirred continuously for 2 hours. Upon completion of the reaction, ice water and acetic acid were carefully added to the reaction mixture to quench the reaction. The resulting mixture was washed with saturated sodium chloride solution and then extracted with ethyl acetate. The organic layer was separated and dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The resulting residue was purified by fast column chromatography to give 5.8 g of ethyl (3-methylbenzoyl)acetate in 84% yield. The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 7.73-7.63 (m, 2H), 7.42-7.28 (m, 2H), 4.27-4.18 (m, 2H), 3.97 (s, 2H), 2.40 (s, 3H), 1.36-1.23 (m, 3H).
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 6, p. 1910 - 1915
[2] Patent: WO2005/100297, 2005, A1. Location in patent: Page/Page column 28-29
[3] Patent: WO2005/100303, 2005, A1. Location in patent: Page/Page column 56
[4] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 7, p. 2590 - 2594
[5] Angewandte Chemie - International Edition, 2012, vol. 51, # 34, p. 8661 - 8664
3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER manufacturers
- Product
- 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER 33166-79-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-31