ChemicalBook > CAS DataBase List > 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER

3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER

Product Name
3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER
CAS No.
33166-79-9
Chemical Name
3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER
Synonyms
Ethyl m-toluoylacetate;Ethyl m-methylbenzoylacetate;ETHYL (3-METHYLBENZOYL)ACETATE;ETHYL 3-OXO-3-M-TOLYLPROPANOATE;Ethyl 2-(3-methylbenzoyl)acetate;Ethyl 3-oxo-3-(m-tolyl)propionate;2-[(3-methylphenyl)-oxomethyl]butanoate;ETHYL 3-(3-METHYLPHENYL)-3-OXOPROPANOATE;3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER;3-OXO-3-(3-TOLYL)PROPIONIC ACID ETHYL ESTER
CBNumber
CB1732689
Molecular Formula
C12H14O3
Formula Weight
206.24
MOL File
33166-79-9.mol
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3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER Property

Boiling point:
273-274 °C(lit.)
Density 
1.083 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5290(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
Appearance
Colorless to light yellow Liquid
CAS DataBase Reference
33166-79-9(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
559180
Product name
Ethyl (3-methylbenzoyl)acetate
Packaging
1g
Price
$113.05
Updated
2025/07/31
TRC
Product number
E926713
Product name
Ethyl3-Oxo-3-(m-tolyl)propanoate
Packaging
500mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
B825
Product name
Ethyl (3-methylbenzoyl)acetate
Packaging
5g
Price
$253
Updated
2021/12/16
Matrix Scientific
Product number
079830
Product name
Ethyl 3-(3-methylphenyl)-3-oxopropanoate
Packaging
1g
Price
$109
Updated
2021/12/16
Matrix Scientific
Product number
079830
Product name
Ethyl 3-(3-methylphenyl)-3-oxopropanoate
Packaging
5g
Price
$452
Updated
2021/12/16
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3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

Reactant for:• ;Stereoselective ketonization-olefination of indoles by Co/Mn-mediated oxidative cross-coupling of indoles via dioxygen activation1• ;Enantioselective Michael reaction2• ;SEGPhos-ruthenium-catalyzed asymmetric hydrogenation3

Uses

Reactant for:

  • Stereoselective ketonization-olefination of indoles by Co/Mn-mediated oxidative cross-coupling of indoles via dioxygen activation
  • Enantioselective Michael reaction
  • SEGPhos-ruthenium-catalyzed asymmetric hydrogenation

Synthesis

105-58-8

585-74-0

33166-79-9

GENERAL STEPS: In a dry reaction flask, sodium hydride (3.1 g, 77.1 mmol) was suspended in diethyl carbonate, followed by the slow addition of 3'-methylacetophenone (4.5 g, 33.54 mmol). The reaction mixture was heated at 80 °C and stirred continuously for 2 hours. Upon completion of the reaction, ice water and acetic acid were carefully added to the reaction mixture to quench the reaction. The resulting mixture was washed with saturated sodium chloride solution and then extracted with ethyl acetate. The organic layer was separated and dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The resulting residue was purified by fast column chromatography to give 5.8 g of ethyl (3-methylbenzoyl)acetate in 84% yield. The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 7.73-7.63 (m, 2H), 7.42-7.28 (m, 2H), 4.27-4.18 (m, 2H), 3.97 (s, 2H), 2.40 (s, 3H), 1.36-1.23 (m, 3H).

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 6, p. 1910 - 1915
[2] Patent: WO2005/100297, 2005, A1. Location in patent: Page/Page column 28-29
[3] Patent: WO2005/100303, 2005, A1. Location in patent: Page/Page column 56
[4] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 7, p. 2590 - 2594
[5] Angewandte Chemie - International Edition, 2012, vol. 51, # 34, p. 8661 - 8664

3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER manufacturers

Career Henan Chemical Co
Product
3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER 33166-79-9
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-31

33166-79-9, 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTERRelated Search:

3-OXO-3-(3-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER ETHYL 3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-3-OXOPROPANOATE 3-Methylquinoline ETHYL 4-HYDROXY-6-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 3-BIPHENYL-3-YL-3-OXO-PROPIONIC ACID ETHYL ESTER 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER 3-OXO-3-(2-TOLYL)PROPIONIC ACID ETHYL ESTER,3-OXO-3-O-TOLYL-PROPIONIC ACID ETHYL ESTER 3-OXO-3-P-TOLYL-PROPIONIC ACID ETHYL ESTER,3-OXO-3-(4-TOLYL)PROPIONIC ACID ETHYL ESTER 2-(4-NITRO-PHENYL)-3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER AURORA 17725 RARECHEM AL BI 0777 AURORA 17884 RARECHEM AL BI 0585 AURORA 17730 AURORA 17760 ETHYL (3,5-DIMETHYLBENZOYL)ACETATE AURORA 18047 SPECS AG-670/25097010

  • ETHYL 3-OXO-3-M-TOLYLPROPANOATE
  • ETHYL (3-METHYLBENZOYL)ACETATE
  • 3-OXO-3-M-TOLYL-PROPIONIC ACID ETHYL ESTER
  • 3-OXO-3-(3-TOLYL)PROPIONIC ACID ETHYL ESTER
  • ETHYL 3-(3-METHYLPHENYL)-3-OXOPROPANOATE
  • Ethyl 2-(3-methylbenzoyl)acetate
  • Ethyl 3-oxo-3-(m-tolyl)propionate
  • Ethyl m-methylbenzoylacetate
  • Ethyl m-toluoylacetate
  • 3-keto-3-(3-methylphenyl)propionic acid ethyl ester
  • 3-(3-methylphenyl)-3-oxopropanoic acid ethyl ester
  • 2-[(3-methylphenyl)-oxomethyl]butanoate
  • Benzenepropanoic acid, 3-methyl-β-oxo-, ethyl ester
  • 33166-79-9
  • CH3C6H4COCH2CO2CH2CH3
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