N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol

Product Name: N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol
CAS No.: 106946-74-1
Chemical Name: N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol
Synonyms: BOC-ILE-OL;BOC-LLE-OL;Boc-L-Ile-OL;BOC-ISOLEUCINOL;BOC-L-isoleuinol;BOC-L-ISOLEUCINOL;N-BOC-L-ISOLEUCINOL;N-Boc-L-isolucinole;N-T-BOC-L-ISOLEUCINOL;N-ALPHA-T-BOC-L-ISOLEUCINOL
CBNumber: CB1733404
Molecular Formula: C11H23NO3
Formula Weight: 217.31
MOL File: 106946-74-1.mol

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N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Property

Boiling point:: 121-126 °C0.6 mm Hg
Density: 0.984±0.06 g/cm3(Predicted)
refractive index: n20/D 1.455
Flash point:: >230 °F
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in water or 1% acetic acid
form: Powder
pka: 12.11±0.46(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure
BRN: 3604099
CAS DataBase Reference: 106946-74-1(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 660205
Product name: N-Boc-(2S,3S)-(?)-2-amino-3-methyl-1-pentanol
Purity: 96%
Packaging: 10g
Price: $342
Updated: 2023/06/20

Usbiological

Product number: 236302
Product name: Boc-Isoleucinol
Packaging: 1g
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 264775
Product name: Boc-Isoleucinol
Packaging: 1g
Price: $366
Updated: 2021/12/16

Chem-Impex

Product number: 03192
Product name: Boc-isoleucinol,98%(Assay)
Purity: 98%(Assay)
Packaging: 25G
Price: $397.6
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47617
Product name: Boc-Isoleucinol
Packaging: 10g
Price: $401.7
Updated: 2021/12/16

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N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Chemical Properties,Usage,Production

Chemical Properties

Colorless Liquid

Synthesis

13139-16-7

141321-52-0

N-Boc-L-isoleucine (13.86 g, 60 mmol) was dissolved in THF (150 mL) under argon protection and cooled to 0°C. A 1 M BH3-THF solution (90 mL, 90 mmol) was slowly added dropwise over 20 min. After keeping 0 °C and continuing to stir for 30 min, the reaction mixture was allowed to gradually warm up to room temperature and stirred for 5 h. The reaction was then carried out at 0 °C for 5 min. Upon completion of the reaction, the mixture was again cooled to 0 °C and water was added dropwise to quench the reaction. Most of the THF was evaporated under reduced pressure and the residue was extracted by adding ethyl acetate (180 mL) and water (60 mL) to the residue. The organic layer was separated, washed sequentially with water (50 mL) and saturated brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give N-Boc-D-isoleucinol (12.89 g, 99% yield) as a colorless oil. The product could be used in the next reaction without further purification. [α]25D +14.8 (c 1.0, MeOH); 1H NMR (400 MHz, CDCl3) δ 5.04 (dd, J=48.3, 13.9 Hz, 1H), 3.73-3.55 (m, 2H), 3.48 (s, 1H), 3.37 (s, 1H), 1.58 (d, J=14.5 Hz, 1H). 1.56-1.48 (m, 1H), 1.45 (s, 9H), 1.23-1.05 (m, 1H), 0.91 (t, J=7.1 Hz, 6H); 13C NMR (100 MHz, CDCl3) δ 156.7, 79.3, 63.4, 56.8, 35.9, 28.4, 25.3, 15.5, 11.4; HRMS (ESI) m/z: [M+Na]+ calculated value C11H23NO3Na 240.1570, measured value 240.1530.

References

[1] Tetrahedron, 2017, vol. 73, # 16, p. 2255 - 2266
[2] Synthesis, 2011, # 9, p. 1375 - 1382
[3] Organic Letters, 2007, vol. 9, # 20, p. 3881 - 3884
[4] Journal of Chemical Research - Part S, 2003, # 8, p. 516 - 517
[5] Journal of Organic Chemistry, 1996, vol. 61, # 3, p. 826 - 830

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol Suppliers

Canada 1 China 122 Germany 5 India 5 Italy 1 Japan 2 Switzerland 1 United Kingdom 4 United States 17 Global 158

Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol 106946-74-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-03

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Ile-ol 106946-74-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol 106946-74-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

106946-74-1, N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanolRelated Search:

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Boc-L-Ile-OL

Boc-Isoleucinol≥ 98% (Assay)

N-Boc-L-isoleucinol,99%e.e.

BOC-L-isoleuinol

N-T-BOC-L-ISOLEUCINOL

N-T-BUTOXYCARBONYL-L-ISOLEUCINOL

N-ALPHA-T-BOC-L-ISOLEUCINOL

N-BOC-(2S,3S)-(-)-2-AMINO-3-METHYL-1-PENTANOL

N-BOC-L-ISOLEUCINOL

BOC-ISOLEUCINOL

BOC-ILE-OL

BOC-LLE-OL

BOC-L-ISOLEUCINOL

BOC-((2S,3S)-2-AMINO)-3-METHYL-1-PENTANOL

N-Boc-L-isolucinole

N-(2S)-Amino-(3S)-methyl-1-pentanol~N-(tert-Butoxycarbonyl)-L-isoleucinol

n-boc-(2s)-amino-(3s)-methyl-1-pentanol

NALPHA-tert-Butoxycarbonyl-L-isoleucinol

N-alpha-t-Butyloxycarbonyl-L-isoleucinol

tert-Butyl N-[(2S,3R)-1-hydroxy-3-methylpentan-2-yl]carbamate

tert-Butyl((2S,3S)-1-hydroxy-3-methylpentan-2-yl)carbamate

N-[(2S,3S)-1-hydroxy-3-methylpentan-2-yl]carbamic acid tert-butyl ester

Carbamic acid, N-[(1S,2S)-1-(hydroxymethyl)-2-methylbutyl]-, 1,1-dimethylethyl ester

N-Boc-(2S,3S)-(-)-2-Amino-3-methyl-1-pentanol USP/EP/BP

N-tert-Butoxycarbonyl-L-isoleucinol

N-Boc-(2S,3S)-(?)-2-amino-3-methyl-1-pentanol

106946-74-1

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