GUANIDINOETHYL SULFONATE
- Product Name
- GUANIDINOETHYL SULFONATE
- CAS No.
- 543-18-0
- Chemical Name
- GUANIDINOETHYL SULFONATE
- Synonyms
- TAUROCYAMINE;SKL456;NSC 667063;Taurocyamin;Amidinotaurine;N-Guanyltaurine;N-Amidinotaurine;taurocyamine zwitterion;GUANIDINOETHYL SULFONATE;Guanidinoethanesulfonic Acid
- CBNumber
- CB1741690
- Molecular Formula
- C3H9N3O3S
- Formula Weight
- 167.19
- MOL File
- 543-18-0.mol
GUANIDINOETHYL SULFONATE Property
- Melting point:
- 263-265°C
- Density
- 1.73±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated), Water (Heated)
- form
- Solid
- pka
- 1.31±0.50(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 543-18-0
Safety
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39
- RIDADR
- 3261
- HS Code
- 2927000090
N-Bromosuccinimide Price
- Product number
- PH017029
- Product name
- 2-{[Amino(imino)methyl]amino}ethanesulfonic acid
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $81.6
- Updated
- 2023/06/20
- Product number
- 17572
- Product name
- Guanidinoethyl sulfonate
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 17572
- Product name
- Guanidinoethyl sulfonate
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $432
- Updated
- 2023/06/20
- Product number
- 17572
- Product name
- Guanidinoethyl sulfonate
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- G827500
- Product name
- GuanidinoethylSulfonate
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
GUANIDINOETHYL SULFONATE Chemical Properties,Usage,Production
Description
Guanidinoethyl sulfonate, also known as taurocyamine, is a natural guanidine-taurine analog derived from taurine. It is an intermediate of taurine and hypotaurine metabolism and is phosphorylated by taurocyamine kinase. Guanidinoethyl sulfonate competitively inhibits taurine uptake by sodium-dependent taurine transporters in rat hepatocytes (Ki = 1.75 mM). It also acts as a competitive glycine receptor antagonist in mouse striatal neurons. Plasma levels of guanidinoethyl sulfonate are significantly increased in patients with chronic renal failure.
Chemical Properties
White Solid
Uses
A potent inhibitor of taurine transport.
Definition
ChEBI: Zwitterionic form of taurocyamine arising from transfer of a proton from the sulfo to the guanidino group; major species at pH 7.3.
in vitro
guanidinoethyl sulphonate was found to be an analogue of taurine and an inhibitor of taurine transport. guanidinoethyl sulphonate was also shown to be a weak agonist at gaba(a) receptors, and was able to antagonize gaba-evoked responses. guanidinoethyl sulphonate did not gate glyr. 3. but antagonized glycine responses in a concentration-dependent and surmountable manner. glycine receptor-mediated taurine responses were competitively antagonized by guanidinoethyl sulphonate. taurine dose-response curves, in contrast to the glycine dose-response curves were shifted by guanidinoethyl sulphonate to the right in a parallel manner [1].
in vivo
guanidinoethyl sulphonate delivered in the drinking water of rats for 1 month could effectively reduce taurine levels in brain structures and outside the brain by between 50 and 80 %, depending on the tissue. this partial taurine depletion could not affect either basal synaptic transmission or the late phase of long-term potentiation in hippocampal slices. in-vivo microdialysis studies in the hippocampus demonstrated that guanidinoethyl sulphonate was able to reduce extracellular taurine levels and the magnitude of taurine released in response to the application of either n-methyl-d-aspartate or a hypoosmotic solution [2].
References
[1] sergeeva, o. a.,chepkova, a.n., and hass, h.l. guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. british journal of pharmacology 137, 855-860 (2002).
[2] suárez lm, muoz md, gonzález jc, bustamante j, del río rm, solís jm. the taurine transporter substrate guanidinoethyl sulfonate mimics the action of taurine on long-term synaptic potentiation. amino acids. 2016 nov;48(11):2647-2656. epub 2016 jul 15.
GUANIDINOETHYL SULFONATE Preparation Products And Raw materials
Raw materials
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View Lastest Price from GUANIDINOETHYL SULFONATE manufacturers
- Product
- GUANIDINOETHYL SULFONATE 543-18-0
- Price
- US $0.37/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg/100kg
- Release date
- 2020-11-09