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GUANIDINOETHYL SULFONATE

Product Name
GUANIDINOETHYL SULFONATE
CAS No.
543-18-0
Chemical Name
GUANIDINOETHYL SULFONATE
Synonyms
TAUROCYAMINE;SKL456;NSC 667063;Taurocyamin;Amidinotaurine;N-Guanyltaurine;N-Amidinotaurine;taurocyamine zwitterion;GUANIDINOETHYL SULFONATE;Guanidinoethanesulfonic Acid
CBNumber
CB1741690
Molecular Formula
C3H9N3O3S
Formula Weight
167.19
MOL File
543-18-0.mol
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GUANIDINOETHYL SULFONATE Property

Melting point:
263-265°C
Density 
1.73±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated), Water (Heated)
form 
Solid
pka
1.31±0.50(Predicted)
color 
White to Off-White
CAS DataBase Reference
543-18-0
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Safety

Risk Statements 
34
Safety Statements 
26-36/37/39
RIDADR 
3261
HS Code 
2927000090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PH017029
Product name
2-{[Amino(imino)methyl]amino}ethanesulfonic acid
Purity
AldrichCPR
Packaging
1G
Price
$81.6
Updated
2023/06/20
Cayman Chemical
Product number
17572
Product name
Guanidinoethyl sulfonate
Purity
≥95%
Packaging
1g
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
17572
Product name
Guanidinoethyl sulfonate
Purity
≥95%
Packaging
5g
Price
$432
Updated
2023/06/20
Cayman Chemical
Product number
17572
Product name
Guanidinoethyl sulfonate
Purity
≥95%
Packaging
500mg
Price
$50
Updated
2024/03/01
TRC
Product number
G827500
Product name
GuanidinoethylSulfonate
Packaging
1g
Price
$110
Updated
2021/12/16
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GUANIDINOETHYL SULFONATE Chemical Properties,Usage,Production

Description

Guanidinoethyl sulfonate, also known as taurocyamine, is a natural guanidine-taurine analog derived from taurine. It is an intermediate of taurine and hypotaurine metabolism and is phosphorylated by taurocyamine kinase. Guanidinoethyl sulfonate competitively inhibits taurine uptake by sodium-dependent taurine transporters in rat hepatocytes (Ki = 1.75 mM). It also acts as a competitive glycine receptor antagonist in mouse striatal neurons. Plasma levels of guanidinoethyl sulfonate are significantly increased in patients with chronic renal failure.

Chemical Properties

White Solid

Uses

A potent inhibitor of taurine transport.

Definition

ChEBI: Zwitterionic form of taurocyamine arising from transfer of a proton from the sulfo to the guanidino group; major species at pH 7.3.

in vitro

guanidinoethyl sulphonate was found to be an analogue of taurine and an inhibitor of taurine transport. guanidinoethyl sulphonate was also shown to be a weak agonist at gaba(a) receptors, and was able to antagonize gaba-evoked responses. guanidinoethyl sulphonate did not gate glyr. 3. but antagonized glycine responses in a concentration-dependent and surmountable manner. glycine receptor-mediated taurine responses were competitively antagonized by guanidinoethyl sulphonate. taurine dose-response curves, in contrast to the glycine dose-response curves were shifted by guanidinoethyl sulphonate to the right in a parallel manner [1].

in vivo

guanidinoethyl sulphonate delivered in the drinking water of rats for 1 month could effectively reduce taurine levels in brain structures and outside the brain by between 50 and 80 %, depending on the tissue. this partial taurine depletion could not affect either basal synaptic transmission or the late phase of long-term potentiation in hippocampal slices. in-vivo microdialysis studies in the hippocampus demonstrated that guanidinoethyl sulphonate was able to reduce extracellular taurine levels and the magnitude of taurine released in response to the application of either n-methyl-d-aspartate or a hypoosmotic solution [2].

References

[1] sergeeva, o. a.,chepkova, a.n., and hass, h.l. guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. british journal of pharmacology 137, 855-860 (2002).
[2] suárez lm, muoz md, gonzález jc, bustamante j, del río rm, solís jm. the taurine transporter substrate guanidinoethyl sulfonate mimics the action of taurine on long-term synaptic potentiation. amino acids. 2016 nov;48(11):2647-2656. epub 2016 jul 15.

GUANIDINOETHYL SULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GUANIDINOETHYL SULFONATE manufacturers

Career Henan Chemica Co
Product
GUANIDINOETHYL SULFONATE 543-18-0
Price
US $0.37/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg/100kg
Release date
2020-11-09

543-18-0, GUANIDINOETHYL SULFONATERelated Search:


  • 2-GUANIDINOETHANE SULFONIC ACID
  • 2-([AMINO(IMINO)METHYL]AMINO)ETHANE-1-SULFONIC ACID
  • GUANIDINOETHYL SULFONATE
  • TAUROCYAMINE
  • 2-{[amino(imino)methyl]amino}ethane-1-sulphonic acid
  • N-Amidinotaurine
  • 2-(diaminomethylideneamino)ethanesulfonic acid
  • 2-[(Aminoiminomethyl)amino]thanesulfonic Acid
  • 2-Guanylaminoethanesulfonic Acid
  • Amidinotaurine
  • Guanidinoethanesulfonic Acid
  • N-Guanyltaurine
  • NSC 667063
  • Taurocyamin
  • taurocyamine zwitterion
  • Ethanesulfonic acid,2-[(aminoiminomethyl)amino]-
  • SKL456
  • Guanidinoethyl sulfonate,Endogenous Metabolite,inhibit,Inhibitor,taurine transport antagonist
  • 543-18-0
  • C3H9N3O3S
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds