4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

Product Name: 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID
CAS No.: 725-14-4
Chemical Name: 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID
Synonyms: AKOS BAR-0018;RARECHEM AL BE 1217;CHEMBRDG-BB 5555852;4-(4-METHOXYPHENYL)BENZOIC ACID;4'-Methoxy-4-biphenylcarboxylicacid;4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID;4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID;4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy-;4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid
CBNumber: CB1743568
Molecular Formula: C14H12O3
Formula Weight: 228.24
MOL File: 725-14-4.mol

More

Less

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Property

Melting point:: 253-256°
Boiling point:: 406.4±38.0 °C(Predicted)
Density: 1.193±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 4.28±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 725-14-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TRC

Product number: M329528
Product name: 4-(4-Methoxyphenyl)benzoicacid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 045780
Product name: 4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid
Purity: >95%
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 3565CH
Product name: 4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid
Packaging: 1g
Price: $77
Updated: 2021/12/16

Matrix Scientific

Product number: 045780
Product name: 4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid
Purity: >95%
Packaging: 500mg
Price: $35
Updated: 2021/12/16

AK Scientific

Product number: 3565CH
Product name: 4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid
Packaging: 25g
Price: $284
Updated: 2021/12/16

More

Less

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1648, 1946 DOI: 10.1021/ja01212a086

Synthesis

619-58-9

5720-07-0

725-14-4

A reaction mixture was prepared using 4-methoxyphenylboronic acid (1 g, 6.58 mmol) and 4-iodobenzoic acid (1.63 g, 6.58 mmol) as raw materials and cesium carbonate (5.36 g, 16.45 mmol) as base in a 3:1 solvent mixture of 1,2-dimethoxyethane/water. The reaction system was degassed with nitrogen for 15 min and then tetrakis(triphenylphosphine)palladium (380 mg, 0.329 mmol) was added as catalyst. The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 6 hours. Upon completion of the reaction, it was cooled to room temperature and acidified with 2M hydrochloric acid to pH<7, at which point a precipitate was generated. The precipitate was collected by filtration and the filtrate was extracted twice with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered through diatomaceous earth and concentrated under reduced pressure to give 1.50 g of 4'-methoxybiphenyl-4-carboxylic acid in 95% yield. The product was characterized by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6) with the following data: 1H NMR (DMSO-d6): δ 7.99 (d, J = 8.4 Hz, 2H), 7.74 (d, J = 8.4 Hz, 2H), 7.69 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 3.80 (d, J = 8.7 Hz, 3.80 (d, J = 8.7 Hz, 2H), 4.50g of 4'-methoxybiphenyl-4-carboxylic acid. 2H), 3.80 (s, 3H); 13C NMR (DMSO-d6): δ 167.17, 159.49, 143.90, 131.16, 129.91, 128.77, 128.09, 126.08, 114.45, 55.17.

References

[1] Russian Chemical Bulletin, 2007, vol. 56, # 2, p. 369 - 370
[2] Green Chemistry, 2010, vol. 12, # 1, p. 150 - 158
[3] Patent: WO2009/146013, 2009, A1. Location in patent: Page/Page column 52
[4] Green Chemistry, 2009, vol. 11, # 12, p. 1929 - 1932
[5] Tetrahedron, 2012, vol. 68, # 32, p. 6517 - 6520

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Suppliers

China 53 Germany 5 India 2 Russia 1 Ukraine 2 United Kingdom 5 United States 11 Global 79

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: 15026594951
Fax: 0556-5030632
Email: rs@raise-chem.com
Country: China
ProdList: 4454
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

More

Less

View Lastest Price from 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 4'-Methoxy-4-biphenylcarboxylic acid 725-14-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-08

725-14-4, 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACIDRelated Search:

4-N-PROPYLOXYBIPHENYL-4'-CARBOXYLIC ACID 4-N-OCTYLOXYBIPHENYL-4'-CARBOXYLIC ACID Biphenyl 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID (R)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE 4'-(NONYLOXY)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID 4-ETHOXY-4'-BIPHENYLCARBOXYLIC ACID 3'-FLUORO-4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE METHYL 4'-METHOXYBIPHENYL-4-CARBOXYLATE 4-(PENTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEXYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEPTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4'-N-DECYLOXYBIPHENYL-4-CARBOXYLIC ACID (S)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE 4-BUTOXY-4'-BIPHENYLCARBOXYLIC ACID 4'-ACETOXY-BIPHENYL-4-CARBOXYLIC ACID 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER

CHEMBRDG-BB 5555852

4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID

4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

4-(4-METHOXYPHENYL)BENZOIC ACID

AKOS BAR-0018

[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 4'-METHOXY-

RARECHEM AL BE 1217

4'-Methoxy-4-biphenylcarboxylicacid

4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid

1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy-

4′-Methoxybiphenyl-4-carboxylic acid, CAS 725-14-4

725-14-4

pharmacetical