ChemicalBook > CAS DataBase List > 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

Product Name
4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID
CAS No.
725-14-4
Chemical Name
4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID
Synonyms
AKOS BAR-0018;RARECHEM AL BE 1217;CHEMBRDG-BB 5555852;4-(4-METHOXYPHENYL)BENZOIC ACID;4'-Methoxy-4-biphenylcarboxylicacid;4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID;4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID;4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy-;4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid
CBNumber
CB1743568
Molecular Formula
C14H12O3
Formula Weight
228.24
MOL File
725-14-4.mol
More
Less

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Property

Melting point:
253-256°
Boiling point:
406.4±38.0 °C(Predicted)
Density 
1.193±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
4.28±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
725-14-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M329528
Product name
4-(4-Methoxyphenyl)benzoicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
045780
Product name
4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid
Purity
>95%
Packaging
1g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
3565CH
Product name
4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid
Packaging
1g
Price
$77
Updated
2021/12/16
Matrix Scientific
Product number
045780
Product name
4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid
Purity
>95%
Packaging
500mg
Price
$35
Updated
2021/12/16
AK Scientific
Product number
3565CH
Product name
4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid
Packaging
25g
Price
$284
Updated
2021/12/16
More
Less

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1648, 1946 DOI: 10.1021/ja01212a086

Synthesis

619-58-9

5720-07-0

725-14-4

A reaction mixture was prepared using 4-methoxyphenylboronic acid (1 g, 6.58 mmol) and 4-iodobenzoic acid (1.63 g, 6.58 mmol) as raw materials and cesium carbonate (5.36 g, 16.45 mmol) as base in a 3:1 solvent mixture of 1,2-dimethoxyethane/water. The reaction system was degassed with nitrogen for 15 min and then tetrakis(triphenylphosphine)palladium (380 mg, 0.329 mmol) was added as catalyst. The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 6 hours. Upon completion of the reaction, it was cooled to room temperature and acidified with 2M hydrochloric acid to pH<7, at which point a precipitate was generated. The precipitate was collected by filtration and the filtrate was extracted twice with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered through diatomaceous earth and concentrated under reduced pressure to give 1.50 g of 4'-methoxybiphenyl-4-carboxylic acid in 95% yield. The product was characterized by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6) with the following data: 1H NMR (DMSO-d6): δ 7.99 (d, J = 8.4 Hz, 2H), 7.74 (d, J = 8.4 Hz, 2H), 7.69 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 3.80 (d, J = 8.7 Hz, 3.80 (d, J = 8.7 Hz, 2H), 4.50g of 4'-methoxybiphenyl-4-carboxylic acid. 2H), 3.80 (s, 3H); 13C NMR (DMSO-d6): δ 167.17, 159.49, 143.90, 131.16, 129.91, 128.77, 128.09, 126.08, 114.45, 55.17.

References

[1] Russian Chemical Bulletin, 2007, vol. 56, # 2, p. 369 - 370
[2] Green Chemistry, 2010, vol. 12, # 1, p. 150 - 158
[3] Patent: WO2009/146013, 2009, A1. Location in patent: Page/Page column 52
[4] Green Chemistry, 2009, vol. 11, # 12, p. 1929 - 1932
[5] Tetrahedron, 2012, vol. 68, # 32, p. 6517 - 6520

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Suppliers

China 53 Germany 5 India 2 Russia 1 Ukraine 2 United Kingdom 5 United States 11 Global 79
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
AKos Consulting & Solutions GmbH
Tel
--
Fax
--
Email
akos@akosgmbh.de
Country
Germany
ProdList
6717
Advantage
72
ChemCollect GmbH
Tel
--
Fax
--
Email
contact@chemcollect.de
Country
Germany
ProdList
6214
Advantage
54
Rare Chemicals GmbH
Tel
--
Fax
--
Email
sales@rarechem.de
Country
Germany
ProdList
6297
Advantage
38
More
Less

View Lastest Price from 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
4'-Methoxy-4-biphenylcarboxylic acid 725-14-4
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-08

725-14-4, 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACIDRelated Search:

4-N-PROPYLOXYBIPHENYL-4'-CARBOXYLIC ACID 4-N-OCTYLOXYBIPHENYL-4'-CARBOXYLIC ACID Biphenyl 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID (R)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE 4'-(NONYLOXY)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID 4-ETHOXY-4'-BIPHENYLCARBOXYLIC ACID 3'-FLUORO-4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE METHYL 4'-METHOXYBIPHENYL-4-CARBOXYLATE 4-(PENTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEXYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEPTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4'-N-DECYLOXYBIPHENYL-4-CARBOXYLIC ACID (S)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE 4-BUTOXY-4'-BIPHENYLCARBOXYLIC ACID 4'-ACETOXY-BIPHENYL-4-CARBOXYLIC ACID 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER

  • CHEMBRDG-BB 5555852
  • 4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID
  • 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID
  • 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID
  • 4-(4-METHOXYPHENYL)BENZOIC ACID
  • AKOS BAR-0018
  • [1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 4'-METHOXY-
  • RARECHEM AL BE 1217
  • 4'-Methoxy-4-biphenylcarboxylicacid
  • 4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid
  • 1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy-
  • 4′-Methoxybiphenyl-4-carboxylic acid, CAS 725-14-4
  • 725-14-4
  • pharmacetical