ChemicalBook > CAS DataBase List > 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

Product Name: 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID
CAS No.: 725-14-4
Chemical Name: 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID
Synonyms: AKOS BAR-0018;RARECHEM AL BE 1217;CHEMBRDG-BB 5555852;4-(4-METHOXYPHENYL)BENZOIC ACID;4'-Methoxy-4-biphenylcarboxylicacid;4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID;4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID;4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy-;4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid
CBNumber: CB1743568
Molecular Formula: C14H12O3
Formula Weight: 228.24
MOL File: 725-14-4.mol

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4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Property

Melting point:: 253-256°
Boiling point:: 406.4±38.0 °C(Predicted)
Density: 1.193±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 4.28±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 725-14-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: M329528
Product name: 4-(4-Methoxyphenyl)benzoicacid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 045780
Product name: 4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid
Purity: >95%
Packaging: 1g
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 3565CH
Product name: 4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid
Packaging: 1g
Price: $77
Updated: 2021/12/16

Matrix Scientific

Product number: 045780
Product name: 4'-Methoxy[1,1'-biphenyl]-4-carboxylic acid
Purity: >95%
Packaging: 500mg
Price: $35
Updated: 2021/12/16

AK Scientific

Product number: 3565CH
Product name: 4'-Methoxy-[1,1'-biphenyl]-4-carboxylicacid
Packaging: 25g
Price: $284
Updated: 2021/12/16

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4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1648, 1946 DOI: 10.1021/ja01212a086

Synthesis

619-58-9

5720-07-0

725-14-4

A reaction mixture was prepared using 4-methoxyphenylboronic acid (1 g, 6.58 mmol) and 4-iodobenzoic acid (1.63 g, 6.58 mmol) as raw materials and cesium carbonate (5.36 g, 16.45 mmol) as base in a 3:1 solvent mixture of 1,2-dimethoxyethane/water. The reaction system was degassed with nitrogen for 15 min and then tetrakis(triphenylphosphine)palladium (380 mg, 0.329 mmol) was added as catalyst. The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 6 hours. Upon completion of the reaction, it was cooled to room temperature and acidified with 2M hydrochloric acid to pH<7, at which point a precipitate was generated. The precipitate was collected by filtration and the filtrate was extracted twice with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered through diatomaceous earth and concentrated under reduced pressure to give 1.50 g of 4'-methoxybiphenyl-4-carboxylic acid in 95% yield. The product was characterized by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6) with the following data: 1H NMR (DMSO-d6): δ 7.99 (d, J = 8.4 Hz, 2H), 7.74 (d, J = 8.4 Hz, 2H), 7.69 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 7.04 (d, J = 8.7 Hz, 2H), 3.80 (d, J = 8.7 Hz, 3.80 (d, J = 8.7 Hz, 2H), 4.50g of 4'-methoxybiphenyl-4-carboxylic acid. 2H), 3.80 (s, 3H); 13C NMR (DMSO-d6): δ 167.17, 159.49, 143.90, 131.16, 129.91, 128.77, 128.09, 126.08, 114.45, 55.17.

References

[1] Russian Chemical Bulletin, 2007, vol. 56, # 2, p. 369 - 370
[2] Green Chemistry, 2010, vol. 12, # 1, p. 150 - 158
[3] Patent: WO2009/146013, 2009, A1. Location in patent: Page/Page column 52
[4] Green Chemistry, 2009, vol. 11, # 12, p. 1929 - 1932
[5] Tetrahedron, 2012, vol. 68, # 32, p. 6517 - 6520

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 4'-Methoxy-4-biphenylcarboxylic acid 725-14-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-08

725-14-4, 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACIDRelated Search:

4-N-PROPYLOXYBIPHENYL-4'-CARBOXYLIC ACID 4-N-OCTYLOXYBIPHENYL-4'-CARBOXYLIC ACID Biphenyl 4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID (R)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE 4'-(NONYLOXY)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID 4-ETHOXY-4'-BIPHENYLCARBOXYLIC ACID 3'-FLUORO-4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE METHYL 4'-METHOXYBIPHENYL-4-CARBOXYLATE 4-(PENTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEXYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4-(HEPTYLOXY)-4'-BIPHENYLCARBOXYLIC ACID 4'-N-DECYLOXYBIPHENYL-4-CARBOXYLIC ACID (S)-4-[(1-METHYLHEPTYLOXY)CARBONYL]PHENYL 4'-OCTYLOXY-4-BIPHENYLCARBOXYLATE 4-BUTOXY-4'-BIPHENYLCARBOXYLIC ACID 4'-ACETOXY-BIPHENYL-4-CARBOXYLIC ACID 2'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID ETHYL ESTER

CHEMBRDG-BB 5555852

4-BIPHENYL-(4'-METHOXY)CARBOXYLIC ACID

4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID

4'-METHOXY-BIPHENYL-4-CARBOXYLIC ACID

4-(4-METHOXYPHENYL)BENZOIC ACID

AKOS BAR-0018

[1,1'-BIPHENYL]-4-CARBOXYLIC ACID, 4'-METHOXY-

RARECHEM AL BE 1217

4'-Methoxy-4-biphenylcarboxylicacid

4'-Methoxy-[1,1'-biphenyl]-4-carboxylic acid

1,1'-Biphenyl]-4-carboxylicacid, 4'-methoxy-

4′-Methoxybiphenyl-4-carboxylic acid, CAS 725-14-4

725-14-4

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