Acetoacetamide Property

Melting point:

53-56 °C(lit.)

Boiling point:

271.0±23.0 °C(Predicted)

Density 

1.093±0.06 g/cm3(Predicted)

vapor pressure 

0.93Pa at 20℃

Flash point:

>230 °F

storage temp. 

Refrigerator

solubility 

water: soluble1g/10 mL, clear, colorless

form 

Crystalline Powder

pka

12.38±0.46(Predicted)

color 

white to yellowish

Water Solubility 

1000g/L at 20℃

BRN 

1560550

InChIKey

GCPWJFKTWGFEHH-UHFFFAOYSA-N

LogP

-1.4 at 23℃

CAS DataBase Reference

5977-14-0(CAS DataBase Reference)

EPA Substance Registry System

Butanamide, 3-oxo- (5977-14-0)

Safety

WGK Germany 

1

RTECS 

EJ3667188

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Acetoacetamide Chemical Properties,Usage,Production

Chemical Properties

White to yellowish crystals

Uses

Acetoacetamide is used as intermediate for different organic syntheses, mainly organic dyestuffs. Product Data Sheet

Uses

Acetoacetamide was used in a study to assess the stability of artificial sweeteners- aspartame, acesulfame-K and binary sweetener blend of aspartame x acesulfame-K during storage. Acetoacetamide was also used in analysis of multiple sweeteners and their degradation products in lassi by HPLC.

Uses

Acetoacetamide is a β-keto amide commonly used in building heterocyclic systems. It can be used in synthesizing various N-substituted acetoacetamides, that are primary precursors for several organic dyes and pigments.

Definition

ChEBI: Acetoacetamide is a monocarboxylic acid amide of acetoacetic acid. It is functionally related to an acetoacetic acid.

General Description

Acetoacetamide is a degradation product of acesulfame-K, sweetener. Acetoacetamide undergoes alkaline hydrolysis to form salt of acetoacetic acid.

Flammability and Explosibility

Not classified

Purification Methods

Recrystallise the amide from CHCl3, or Me2CO/pet ether. It also crystallises from pyridine with 4mols of solvent. It is slightly soluble in H2O, EtOH and AcOH but is insoluble in Et2O. The phenylhydrazone has m 128o. [Kato Chem Pharm Bull Jpn 15 921 923 1967, Claisen & Meyer Chem Ber 35 583 1902, Beilstein 3 H 659, 3 I 231, 3 III 1204, 3 IV 1545.]