4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 676448-17-2
- Chemical Name
- 4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- N-Boc-4-bromoindole;1-Boc-4-bromoindole;4-BROMOINDOLE, N-BOC PROTECTED;4-Bromo-1H-indole, N-BOC protected;4-Bromo-1H-indole, N-BOC protected 95%;tert-butyl 4-bromo-1H-indole-1-carboxylate;4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;1H-Indole-1-carboxylic acid, 4-bromo-, 1,1-dimethylethyl ester;tert-Butyl 4-bromo-1H-indole-1-carboxylate, 4-Bromo-1-(tert-butoxycarbonyl)-1H-indole
- CBNumber
- CB1744378
- Molecular Formula
- C13H14BrNO2
- Formula Weight
- 296.16
- MOL File
- 676448-17-2.mol
4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Melting point:
- 183 - 185°C
- Boiling point:
- 367.9±34.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly, Heated, Sonicated)
- form
- Solid
- color
- White to Off-White
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B200943
- Product name
- 1-BOC-4-Bromoindole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR1655
- Product name
- 4-Bromo-1H-indole,N-BOCprotected
- Purity
- 95%
- Packaging
- 500mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H56-9-T4
- Product name
- 4-Bromoindole, N-Boc protected
- Purity
- 95%
- Packaging
- 500mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- OR1655
- Product name
- 4-Bromo-1H-indole,N-BOCprotected
- Purity
- 95%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 4H56-9-T4
- Product name
- 4-Bromoindole, N-Boc protected
- Purity
- 95%
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
52488-36-5
24424-99-5
676448-17-2
The general procedure for the synthesis of 1-Boc-4-bromoindole from 4-bromoindole and di-tert-butyl dicarbonate was as follows: di-tert-butyl dicarbonate (17 g, 76.5 mmol) was slowly added to tetrahydrofuran (THF, 120 mL) containing 4-bromoindole (10 g, 51 mmol) and 4-dimethylaminopyridine (DMAP, 0.62 g, 0.51 mmol) solution. The reaction mixture was stirred at room temperature for 15 min before the solvent was removed by rotary evaporation. The residual oil was dissolved in ether and extracted by partitioning with deionized water. The separated ether layer was washed sequentially with saturated sodium bicarbonate solution (3 x 50 mL) and brine (1 x 75 mL). The washed ether layer was dried with anhydrous magnesium sulfate, filtered and the solvent was again removed by rotary evaporation. The resulting brown oil was purified by silica gel column chromatography with the eluent ethyl acetate:hexane (1:100, v/v) to give 15 g (100% yield) of tert-butyl 4-bromo-indole-1-carboxylate (1-Boc-4-bromoindole).
References
[1] Patent: US2004/72844, 2004, A1. Location in patent: Page/Page column 13-14
[2] Patent: CN107973780, 2018, A. Location in patent: Paragraph 0233; 0234; 0235; 0236
[3] Tetrahedron, 2009, vol. 65, # 34, p. 6877 - 6881
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9179 - 9195
[5] Tetrahedron Letters, 2017, vol. 58, # 15, p. 1499 - 1500
4-BROMOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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