4-Nitrophenyl isocyanate Property

Melting point:

56-59 °C(lit.)

Boiling point:

137-138 °C11 mm Hg(lit.)

Density 

1.5018 (rough estimate)

refractive index 

1.5300 (estimate)

Flash point:

>110°C

storage temp. 

2-8°C

solubility 

soluble in Benzene,Toluene

form 

Crystalline Solid

color 

Yellow

Water Solubility 

Insoluble in water.

Sensitive 

Moisture Sensitive

BRN 

389516

CAS DataBase Reference

100-28-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-isocyanato-4-nitro-(100-28-7)

EPA Substance Registry System

p-Nitrophenyl isocyanate (100-28-7)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-42

Safety Statements 

22-26-36/37/39-45

RIDADR 

2206

WGK Germany 

3

RTECS 

DA3692500

F 

10-19-21

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29291090

Toxicity

LD50 orl-rat: 1600 mg/kg NTIS** OTS0528342

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Nitrophenyl isocyanate Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline solid

Uses

4-Nitrophenyl isocyanate is used as pharmaceutical intermediates. 4-Nitrophenyl isocyanate was used in the synthesis of 2-(5-methyl-3,4-diphenyl-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide.

Safety Profile

A poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic vapors of NOx.

Purification Methods

Distil the isocyanate in a vacuum, and/or recrystallise it from pet ether (b 28-38o), *C6H6/pet ether (m 58o) or CCl4 (m 56-57o). [Beilstein 12 H 725, 12 III 1630.]