4-Chlorophenyl isocyanate
- Product Name
- 4-Chlorophenyl isocyanate
- CAS No.
- 104-12-1
- Chemical Name
- 4-Chlorophenyl isocyanate
- Synonyms
- 1-Chloro-4-isocyanatobenzene;P-CHLOROPHENYL ISOCYANATE;PCPI;4-Chlorphenylisocyanate;PARA CHLOROPHENYL ISOCYANATE;pcic;4-Chlorophenyl isocy;p-Chlorfenylisokyanat;4-Chlorphenylisocyanat;chlorophenylisocyanate
- CBNumber
- CB6680525
- Molecular Formula
- C7H4ClNO
- Formula Weight
- 153.57
- MOL File
- 104-12-1.mol
4-Chlorophenyl isocyanate Property
- Melting point:
- 26-29 °C (lit.)
- Boiling point:
- 203-204 °C (lit.)
- Density
- 1.2 g/mL at 25 °C (lit.)
- vapor pressure
- 30Pa at 20℃
- refractive index
- n20/D 1.5618(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly)
- form
- Crystalline Solid
- color
- White to yellow
- Odor
- sharp irritating odor
- Water Solubility
- DECOMPOSES
- Sensitive
- Moisture Sensitive/Lachrymatory
- BRN
- 386235
- LogP
- 3.12 at 22℃
- CAS DataBase Reference
- 104-12-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1-chloro-4-isocyanato-(104-12-1)
- EPA Substance Registry System
- p-Chlorophenyl isocyanate (104-12-1)
Safety
- Hazard Codes
- T+,T,C
- Risk Statements
- 25-26-37/38-41-42-52/53
- Safety Statements
- 23-26-28-36/37/39-45-61-38-37/39-28A-22
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- NQ8575000
- F
- 10-19-21
- Hazard Note
- Toxic/Corrosive/Lachrymatory/Moisture Sensitive
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29291090
- Hazardous Substances Data
- 104-12-1(Hazardous Substances Data)
- Toxicity
- mammal (species unspecified),LC50,inhalation,53mg/m3 (53mg/m3),Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 11(4), Pg. 23, 1967.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H330Fatal if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 152277
- Product name
- 4-Chlorophenyl isocyanate
- Purity
- 98%
- Packaging
- 5g
- Price
- $54.2
- Updated
- 2024/03/01
- Product number
- 152277
- Product name
- 4-Chlorophenyl isocyanate
- Purity
- 98%
- Packaging
- 100g
- Price
- $116
- Updated
- 2024/03/01
- Product number
- A14966
- Product name
- 4-Chlorophenyl isocyanate, 98%
- Packaging
- 5g
- Price
- $21.65
- Updated
- 2024/03/01
- Product number
- A14966
- Product name
- 4-Chlorophenyl isocyanate, 98%
- Packaging
- 25g
- Price
- $41.65
- Updated
- 2024/03/01
- Product number
- A14966
- Product name
- 4-Chlorophenyl isocyanate, 98%
- Packaging
- 100g
- Price
- $104.65
- Updated
- 2024/03/01
4-Chlorophenyl isocyanate Chemical Properties,Usage,Production
Chemical Properties
white to yellow crystalline solid
Uses
4-Chlorophenyl isocyanate is used in the preparation of isothiocyanates. Aryl isocyanates undergo [2+2] cycloaddition reactions with dihydrofuran to give bicyclic ?-lactams in high yield.
Uses
4-Chlorophenyl isocyanate was used in the preparation of isothiocyanates.
Synthesis Reference(s)
The Journal of Organic Chemistry, 34, p. 3200, 1969 DOI: 10.1021/jo01262a089
General Description
Colorless to yellow liquid or crystals. Used as an intermediate in pesticide and pharmaceutical manufacture.
Reactivity Profile
Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Safety Profile
Poison by ingestion and inhalation. Unspecified human systemic effects. A severe eye and moderate skin irritant. A flammable liquid when exposed to heat or flame. Dangerous, can explode on distillation. When heated to decomposition it emits toxic fumes of Cl-, CN-, and NOx.
Purification Methods
Purify the isocyanate by recrystallisation from pet ether (b 30-40o) or better by fractional distillation. TOXIC irritant. [Beilstein 12 H 616, 12 III 1376, 12 IV 1213.]
4-Chlorophenyl isocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chlorophenyl isocyanate manufacturers
- Product
- 4-Chlorophenyl isocyanate 104-12-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.6%
- Supply Ability
- 100000
- Release date
- 2024-04-23
- Product
- 4-Chlorophenyl isocyanate 104-12-1
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-05-25
- Product
- 4-Chlorophenyl isocyanate 104-12-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-17