L-701,324
- Product Name
- L-701,324
- CAS No.
- 142326-59-8
- Chemical Name
- L-701,324
- Synonyms
- L-701;CS-2045;L-701,324;L-701,304;L-701324, 10 mM in DMSO;L 701324, glycine site NMDA receptor antagonist;7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)-quinolinone;7-CHLORO-4-HYDROXY-3-(3-PHENOXY)PHENYL-2(1H)-QUINOLINONE;7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one;7-chloro-1-(4-hydroxy-3-phenoxyphenyl)quinolin-2(1H)-one
- CBNumber
- CB1757589
- Molecular Formula
- C21H14ClNO3
- Formula Weight
- 363.79
- MOL File
- 142326-59-8.mol
L-701,324 Property
- Melting point:
- 308 °C
- Boiling point:
- 584.7±50.0 °C(Predicted)
- Density
- 1.389±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: soluble36.4mg/mL
- form
- solid
- pka
- 4.50±1.00(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 0907
- Product name
- L-701,324
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $156
- Updated
- 2021/12/16
- Product number
- 0907
- Product name
- L-701,324
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $645
- Updated
- 2021/12/16
- Product number
- L009510
- Product name
- L-701,324
- Packaging
- 10mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 453163
- Product name
- L-701,324
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- CS-4968
- Product name
- L-701324
- Purity
- 99.99%
- Packaging
- 10mg
- Price
- $132
- Updated
- 2021/12/16
L-701,324 Chemical Properties,Usage,Production
Uses
L-701,324 is a potential anticonvulsant with high selectivity and affinity for the NMDA receptor glycine site. NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment.
Definition
ChEBI: 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one is a member of quinolines.
Biological Activity
An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
in vivo
L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice[1].
L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus[1].
L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations[2].
| Animal Model: | Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) [1] |
| Dosage: | 5 and 10 mg/kg |
| Administration: | Intraperitoneal injection; daily, for 2 weeks |
| Result: | Reduced the immobility of C57BL/6 J mice. Increased the expression of BDNF, pTrkB and pCREB in the hippocampus. |
| Animal Model: | Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)[1] |
| Dosage: | 5 and 10 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Reduced the immobility of C57BL/6 J mice in the FST and TST. |
| Animal Model: | Male Sprague-Dawley rats (280-300 g)[2] |
| Dosage: | 2.5 and 5 mg/kg |
| Administration: | Oral administration; once |
| Result: | Increased in the percentage of time spent in the open arm in a dose-dependent. Increased punished responding in the Vogel's conflict test in a dose-dependent fashion. |
IC 50
NMDA Receptor
storage
Store at RT
L-701,324 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-701,324 manufacturers
- Product
- L-701,324 142326-59-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13