4-Hydroxypiperidine hydrochloride

Product Name: 4-Hydroxypiperidine hydrochloride
CAS No.: 5382-17-2
Chemical Name: 4-Hydroxypiperidine hydrochloride
Synonyms: 4-PiperidinolHCl;piperidin-4-ol hcl;TIMTEC-BB SBB004192;4-Hydroxypiperidine HCl;4 HYDROXY PIPERADINE HCL;Piperidin-4-olhydrochlorid;4-PIPIRIDINOL HYDROCHLORIDE;4-PIPERIDINOL HYDROCHLORIDE;PIPERIDIN-4-OL HYDROCHLORIDE;2-FLUOROPHENYL HYDRAZINE BASE
CBNumber: CB1758834
Molecular Formula: C5H12ClNO
Formula Weight: 137.61
MOL File: 5382-17-2.mol

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4-Hydroxypiperidine hydrochloride Property

Melting point:: 155-157 °C(lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: methanol: soluble25mg/mL, clear, colorless
form: powder to crystaline
color: White to Orange to Green
Water Solubility: very faint turbidity
BRN: 3908995
InChI: 1S/C5H11NO.ClH/c7-5-1-3-6-4-2-5;/h5-7H,1-4H2;1H
InChIKey: VKCORPXOKYDINR-UHFFFAOYSA-N
SMILES: Cl[H].OC1CCNCC1
CAS DataBase Reference: 5382-17-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3
HS Code: 29333990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 391468
Product name: 4-Hydroxypiperidine hydrochloride
Purity: 98%
Packaging: 5g
Price: $61
Updated: 2023/01/07

TCI Chemical

Product number: H0686
Product name: 4-Hydroxypiperidine Hydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $118
Updated: 2023/06/20

TRC

Product number: H952208
Product name: 4-Hydroxypiperidine hydrochloride
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: H952208
Product name: 4-Hydroxypiperidine hydrochloride
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H952208
Product name: 4-Hydroxypiperidine hydrochloride
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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4-Hydroxypiperidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

4-Hydroxypiperidine, HCl

Uses

4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester.

General Description

4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor.

Synthesis

109384-19-2

5382-17-2

The general procedure for the synthesis of 4-hydroxypiperidine hydrochloride from N-Boc-4-hydroxypiperidine was as follows: tert-butyl 4-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol, 1.00 eq.) was mixed with a saturated HCl solution dissolved in 30 mL of 1,4-dioxane, and the reaction was stirred for 2 h at room temperature. Upon completion of the reaction, the mixture was concentrated in vacuum to afford 4-hydroxypiperidine hydrochloride (3.4 g, 99% yield) as an off-white solid.

References

[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0918; 0919
[2] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 120

4-Hydroxypiperidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxypiperidine hydrochloride Suppliers

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View Lastest Price from 4-Hydroxypiperidine hydrochloride manufacturers

Career Henan Chemical Co

Product: 4-Hydroxypiperidine hydrochloride 5382-17-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

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