4-HYDROXYPHENOXYACETIC ACID Property

Melting point:

154-157 °C (lit.)

Boiling point:

372.6±17.0 °C(Predicted)

Density 

1.367±0.06 g/cm3(Predicted)

solubility 

soluble in Methanol

form 

Fine Crystalline Powder

pka

3.27±0.10(Predicted)

color 

Off-white to beige

BRN 

1952779

LogP

0.650

CAS DataBase Reference

1878-84-8(CAS DataBase Reference)

EPA Substance Registry System

Acetic acid, (4-hydroxyphenoxy)- (1878-84-8)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

TSCA 

Yes

HS Code 

29189990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-HYDROXYPHENOXYACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

off-white to beige fine crystalline powder

Uses

2-(4-Hydroxyphenoxy)acetic Acid is used in the design, synthesis and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hyroxyphenylpyruvate dioxygenase. Acts as a reagent in the preparation, anti-HIV and kinesin Eg5 inhibitory activities, QSAR, and modeling studies of triazolothiadiazole and triazolothiadiazine derivatives. Synthesis of thiadiazolotriazin-4-ones and study of their mosquito-larvicidal and antibacterial properties.

Definition

ChEBI: 4-Hydroxypheoxyacetate is a monocarboxylic acid.

General Description

(4-Hydroxyphenoxy)acetic acid along with formaldehyde ammonium salt forms a polyaromatic anionic compound RG-13577. RG-13577 mimics the synthetic heparin and specifically binds to the vascular smooth muscle cells (SMCs) and inhibits their proliferative growth. In the molecules of (4-hydroxyphenoxy)acetic acid, the carboxyl groups are held together by R₂²(8) hydrogen bonds.