2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID
- Product Name
- 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID
- CAS No.
- 114776-15-7
- Chemical Name
- 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID
- Synonyms
- 2-chloro-4-fluoro-5-nitrobenzoate;2-Chloro-4-fluoro-5-nitrobenzoic ac;2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID;5-Carboxy-4-chloro-2-fluoronitrobenzene;2-Chloro-4-fluoro-5-nitrobenzoicacid98%;Benzoic acid, 2-chloro-4-fluoro-5-nitro-;2-Chloro-4-fluoro-5-nitrobenzoic acid 98%;2-Chloro-4-fluoro-5-nitrobenzoic Acid >2-Chloro-4-fluoro-5-nitrobenzoic acid, 97%,
- CBNumber
- CB1763913
- Molecular Formula
- C7H3ClFNO4
- Formula Weight
- 219.55
- MOL File
- 114776-15-7.mol
2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Property
- Melting point:
- 146-150
- Boiling point:
- 364.2±42.0 °C(Predicted)
- Density
- 1.689±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in methanol.
- pka
- 2.32±0.12(Predicted)
- form
- Powder
- color
- White
- InChI
- InChI=1S/C7H3ClFNO4/c8-4-2-5(9)6(10(13)14)1-3(4)7(11)12/h1-2H,(H,11,12)
- InChIKey
- SYZKAFCPWNFONG-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC([N+]([O-])=O)=C(F)C=C1Cl
- CAS DataBase Reference
- 114776-15-7
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2446
- Product name
- 2-Chloro-4-fluoro-5-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- C2446
- Product name
- 2-Chloro-4-fluoro-5-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $251
- Updated
- 2025/07/31
- Product number
- C367080
- Product name
- 2-Chloro-4-fluoro-5-nitrobenzoic Acid
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-D1754
- Product name
- 2-Chloro-4-fluoro-5-nitrobenzoic Acid
- Purity
- 99.24%
- Packaging
- 10g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- J57080
- Product name
- 2-Chloro-4-fluoro-5-nitrobenzoic Acid
- Packaging
- 10g
- Price
- $40
- Updated
- 2021/12/16
2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Chemical Properties,Usage,Production
Uses
2-Chloro-4-fluoro-5-nitrobenzoic acid is used as pharmaceutical intermediate.
Synthesis
2252-51-9
114776-15-7
The general procedure for the synthesis of 2-chloro-4-fluoro-5-nitrobenzoic acid from 2-chloro-4-fluorobenzoic acid was as follows: 50 g of concentrated sulfuric acid and 0.8 g of the catalyst prepared in Example 1 were added to a reaction flask, followed by the addition of 10 g of 2-chloro-4-fluorobenzoic acid in batches. The reaction mixture was stirred at 25°C for 1 hour. The reaction mixture was cooled to 0°C in an ice bath, and then 5 g of fuming nitric acid was added slowly and dropwise, controlling the reaction temperature between -5 and 8°C. The reaction was continued for 5 to 8 hours until the content of 2-chloro-4-fluorobenzoic acid was less than 0.5%. The reaction mixture was slowly poured into 80 g of crushed ice and the solid product was collected by filtration. The filter cake was washed with 30 g of ice water and subsequently air-dried at 65 °C to give 12.0 g of the white solid product 2-chloro-4-fluoro-5-nitrobenzoic acid in 97.1% yield and 97.2% purity. The isomer of formula (II) was 1.1% by weight.
References
[1] Patent: CN106866684, 2017, A. Location in patent: Paragraph 0131-0132; 0204-0205
[2] Patent: CN106905161, 2017, A. Location in patent: Paragraph 0014; 0015; 0016; 0017
[3] Farmaco, 2004, vol. 59, # 6, p. 463 - 471
[4] Synthesis, 1987, # 10, p. 883 - 887
[5] Patent: US2002/45550, 2002, A1
2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID manufacturers
- Product
- 2-Chloro-4-fluoro-5-nitrobenzoic Acid 114776-15-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2020-01-16
- Product
- 2-Chloro-4-fluoro-5-nitrobenzoic acid 114776-15-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%min
- Supply Ability
- 10tons
- Release date
- 2024-08-05
- Product
- 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID 114776-15-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16