3-Amino-4-fluorobenzoic acid
- Product Name
- 3-Amino-4-fluorobenzoic acid
- CAS No.
- 2365-85-7
- Chemical Name
- 3-Amino-4-fluorobenzoic acid
- Synonyms
- 3-Amino-4-fL;Afatinib Impurity Y;Afatinib Impurity 93;3-Amino-4-Fluorobenzoic;5-Carboxy-2-fluoroaniline;3-AMINO-4-FLUOROBENZOIC ACID;Benzoicacid, 3-amino-4-fluoro-;3-azanyl-4-fluoro-benzoic acid;3-Amino-4-fluorobenzoic Acid >3-AMino-4-fluorobenzoic Acid, 97+%
- CBNumber
- CB9239614
- Molecular Formula
- C7H6FNO2
- Formula Weight
- 155.13
- MOL File
- 2365-85-7.mol
3-Amino-4-fluorobenzoic acid Property
- Melting point:
- 184 °C
- Boiling point:
- 335.5±27.0 °C(Predicted)
- Density
- 1.430±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- pka
- 4.30±0.10(Predicted)
- form
- Powder
- color
- Off-white
- InChI
- InChI=1S/C7H6FNO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,9H2,(H,10,11)
- InChIKey
- WFSPEVFSRUTRCN-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(F)C(N)=C1
- CAS DataBase Reference
- 2365-85-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A1972
- Product name
- 3-Amino-4-fluorobenzoic Acid
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $93
- Updated
- 2024/03/01
- Product number
- A634640
- Product name
- 3-Amino-4-fluorobenzoic Acid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC9442
- Product name
- 3-Amino-4-fluorobenzoic Acid
- Packaging
- 5g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 4657-3-06
- Product name
- 3-Amino-4-fluorobenzoic acid
- Packaging
- 5G
- Price
- $29
- Updated
- 2021/12/16
- Product number
- FA64177
- Product name
- 3-Amino-4-fluorobenzoic acid
- Packaging
- 10g
- Price
- $50
- Updated
- 2021/12/16
3-Amino-4-fluorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
off-white powder
Synthesis
453-71-4
2365-85-7
3-Nitro-4-fluorobenzoic acid (1.85 g, 10.0 mmol) was dissolved in methanol (10 mL) and 5% Pd/C catalyst (100 mg) was added. The reaction mixture was stirred for 6 hours under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to remove the volatile solvent to afford the target product 3-amino-4-fluorobenzoic acid (8A) as a light yellow solid (1.50 g, 9.67 mmol, 97% yield).
References
[1] Patent: US2004/77696, 2004, A1. Location in patent: Page/Page column 11
[2] Patent: WO2010/126922, 2010, A1. Location in patent: Page/Page column 60
[3] Tetrahedron, 2018, vol. 74, # 47, p. 6795 - 6803
[4] Journal of Organic Chemistry, 2014, vol. 79, # 11, p. 5134 - 5144
[5] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 1873 - 1880
3-Amino-4-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-4-fluorobenzoic acid manufacturers
- Product
- Afatinib Impurity 93
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-05-30
- Product
- 3-Amino-4-fluorobenzoic acid 2365-85-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-25
- Product
- 3-Amino-4-fluorobenzoic acid 2365-85-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 10kg; 100kg
- Release date
- 2019-08-30