DIMETHYL PYRIDINE-2,5-DICARBOXYLATE

Product Name: DIMETHYL PYRIDINE-2,5-DICARBOXYLATE
CAS No.: 881-86-7
Chemical Name: DIMETHYL PYRIDINE-2,5-DICARBOXYLATE
Synonyms: Acifluorfen Impurity 7;dimethyl isocinchomeronate;Dimethyl-2,5-pyridinecarboxylate;Dimethy1-2.5-pyridineaarbanylate;DIMETHYL 2,5-PYRIDINEDICARBOXYLATE;DIMETHYL PYRIDINE-2,5-DICARBOXYLATE;METHYL 6-METHOXYCARBONYL NICOTINATE;2,5-pyridine-dimethyl dicarboxylate;2,5-dimethyl pyridine-2,5-dicarboxylate;Dimethyl 2,5-pyridine dicarboxylate 97%
CBNumber: CB1767704
Molecular Formula: C9H9NO4
Formula Weight: 195.17
MOL File: 881-86-7.mol

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DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Property

Melting point:: 213-217 °C(lit.)
Boiling point:: 302.9±22.0 °C(Predicted)
Density: 1.231±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Dichloromethane, Ethyl Acetate
pka: -0.35±0.10(Predicted)
Appearance: White to off-white Solid
Water Solubility: Soluble in Dichloromethane and Ethyl Acetate. Insoluble in water.
BRN: 172251
InChI: InChI=1S/C9H9NO4/c1-13-8(11)6-3-4-7(10-5-6)9(12)14-2/h3-5H,1-2H3
InChIKey: TUGSJNQAIMFEDY-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(C(OC)=O)C=C1
CAS DataBase Reference: 881-86-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 540234
Product name: Dimethyl 2,5-pyridine dicarboxylate
Purity: 97%
Packaging: 25g
Price: $79.62
Updated: 2025/07/31

TRC

Product number: D479050
Product name: Dimethyl 2,5-pyridine dicarboxylate
Packaging: 25g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153579
Product name: Dimethyl pyridine-2,5-dicarboxylate
Packaging: 5G
Price: $40
Updated: 2021/12/16

Matrix Scientific

Product number: 083391
Product name: Dimethyl pyridine-2,5-dicarboxylate
Purity: 97%
Packaging: 25g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153579
Product name: Dimethyl pyridine-2,5-dicarboxylate
Packaging: 10g
Price: $60
Updated: 2021/12/16

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DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Chemical Properties,Usage,Production

Uses

Intermediate for the synthesis of potent antitumor agents.

Uses

It is the intermediate in the synthesis of potent antitumor agents.

General Description

Dimethyl 2,5-pyridine dicarboxylate can be prepared from 2,5-pyridinedicarboxylic acid.

Synthesis

67-56-1

100-26-5

881-86-7

Oxalyl chloride (60.96 g, 480 mmol) was slowly added dropwise over 20 min to a suspension of 2,5-pyridinedicarboxylic acid (20 g, 120 mmol) in dichloromethane (396 mL) and N,N-dimethylformamide (DMF, 6.6 mL). The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was concentrated under reduced pressure by rotary evaporator and the residue was azeotroped with toluene to remove residual water. The residue was dissolved in methanol (276 mL) pre-cooled to 0 °C and stirred for 15 min. Upon completion of the reaction, the solution was concentrated under reduced pressure and the residue was dissolved in ethyl acetate. The organic phase was washed sequentially with saturated aqueous sodium bicarbonate solution, deionized water and saturated brine. Some of the product was collected as a white precipitate. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2,5-pyridinedicarboxylate as a white solid (Yield: 22.93 g, 98% yield). It was analyzed by liquid chromatography-mass spectrometry (LCMS, Method B) with a retention time (R t) of 2.48 min and a molecular ion peak [M + H] + = 196.

References

[1] Patent: WO2009/85983, 2009, A1. Location in patent: Page/Page column 65
[2] Molecules, 2014, vol. 19, # 1, p. 102 - 121
[3] European Journal of Organic Chemistry, 2013, # 3, p. 541 - 549
[4] Tetrahedron Letters, 2005, vol. 46, # 6, p. 967 - 969
[5] Patent: US2007/231300, 2007, A1. Location in patent: Page/Page column 13-14

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Suppliers

Belgium 1 Canada 1 China 154 Germany 3 India 5 Switzerland 1 The Netherlands 1 United Kingdom 8 United States 17 Global 191

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View Lastest Price from DIMETHYL PYRIDINE-2,5-DICARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Dimethyl-2,5-pyridinecarboxylate 881-86-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Career Henan Chemical Co

Product: Dimethyl 2,5-pyridinedicarboxylate 881-86-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-25

881-86-7, DIMETHYL PYRIDINE-2,5-DICARBOXYLATERelated Search:

(Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime 3-amino-2-chloroacrolein 4-Methylsulphonylacetophenone Methyl 6-methylnicotinate 4-Methylsulphonylphenylacetic acid Etoricoxib Impurity 7 2-Chloro-1,3-bis(dimentylamino)trimethinium hexafluorophosphate Etoricoxib Impurity 3 Etoricoxib Impurity 8 Etoricoxib Impurity 13 4-Methylsulphonylbenzoic acid Methyl 2-methylnicotinate 2-Methyl-5-(3-(4-(Methylsulfonyl)phenyl)furan-2-yl)pyridine Etoricoxib iMpurity 1 Deschloro Etoricoxib NA Etoricoxib Impurity 16 Etoricoxib iMpurity 2

METHYL 6-METHOXYCARBONYL NICOTINATE

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE

DIMETHYL 2,5-PYRIDINEDICARBOXYLATE

PYRIDINE-2,5-DICARBOXYLIC ACID DIMETHYL ESTER

2,5-dimethyl pyridine-2,5-dicarboxylate

Dimethyl isocinchomeronate~Pyridine-2,5-dicarboxylic acid dimethyl ester

dimethyl isocinchomeronate

Dimethyl-2,5-pyridinecarboxylate

2,5-Pyridinedicarboxylic acid, 2,5-diMethyl ester

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE HYDROCHLORIDE

Dimethyl pyridine-2,5-dicarboxylate, 98+%

2,5-Pyridinedicarboxylic acid dimethyl ester

Dimethyl 2,5-pyridine dicarboxylate 97%

Dimethyl pyridine-2,5-dicarboxylate 97%

2,5-pyridine-dimethyl dicarboxylate

DIMETHYL PYRIDINE-2,5-DICARBOXYLATE ISO 9001：2015 REACH

Dimethyl-2,5-Pyridine Dicarboxylic Acid

Dimethy1-2.5-pyridineaarbanylate

Acifluorfen Impurity 7

881-86-7

Pyridines

Heterocyclic Building Blocks

C9 to C46

Building Blocks

Pyridine series

Esters

Pyridines

API intermediates

Aromatics

Heterocycles

Intermediates