ChemicalBook > CAS DataBase List > 4-Methylsulphonylphenylacetic acid

4-Methylsulphonylphenylacetic acid

Product Name
4-Methylsulphonylphenylacetic acid
CAS No.
90536-66-6
Chemical Name
4-Methylsulphonylphenylacetic acid
Synonyms
TIMTEC-BB SBB009970;Etoricoxib?USP RC B;Etocoxib impurity 2;4-(Methylsulfonyl)ph;Etoricoxib impurity M;OTHER BUILDING BLOCKS;Etoricoxib Impurity 28;4-MESYLPHENYLACETIC ACID;4-Mesylbenzeneacetic acid;Etoricoxib Intermediate 5
CBNumber
CB8339797
Molecular Formula
C9H10O4S
Formula Weight
214.24
MOL File
90536-66-6.mol
More
Less

4-Methylsulphonylphenylacetic acid Property

Melting point:
136-140 °C(lit.)
Boiling point:
324.37°C (rough estimate)
Density 
1.4230 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.90±0.10(Predicted)
color 
White to Pale Yellow
Water Solubility 
slight
BRN 
2646649
CAS DataBase Reference
90536-66-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29309090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
579114
Product name
4-(Methylsulfonyl)phenylacetic acid
Purity
97%
Packaging
1g
Price
$20
Updated
2023/06/20
Sigma-Aldrich
Product number
579114
Product name
4-(Methylsulfonyl)phenylacetic acid
Purity
97%
Packaging
5g
Price
$21
Updated
2023/06/20
TCI Chemical
Product number
M1899
Product name
4-(Methylsulfonyl)phenylacetic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$28
Updated
2024/03/01
TCI Chemical
Product number
M1899
Product name
4-(Methylsulfonyl)phenylacetic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$83
Updated
2024/03/01
Alfa Aesar
Product number
L19504
Product name
4-(Methylsulfonyl)phenylacetic acid, 97%
Packaging
5g
Price
$51.65
Updated
2024/03/01
More
Less

4-Methylsulphonylphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

yellow to beige-brown crystalline powder

Uses

4-(Methylsulfonyl)phenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Preparation

synthesis of 4-(Methylsulfonyl)phenylacetic acid: 1-(4-Methanesulfonyl-phenyl)-ethanone (20 mmol), morpholine (60 mmol) and elemental sulfur (40 mmol) were added in a round-bottom flask and refluxed for 2 h at 398 K. A 3N solution of NaOH (20 ml) was then added, and the reaction mixture refluxed for an additional 30 min. After cooling, the mixture was filtered and the filtrate was acidified with HCl to pH 6. The solution was again filtered off and washed with ethyl acetate. The resulting aqueous fraction was finally acidified with diluted HCl, to yield the pure product as a white solid. Crystals suitable for X-ray analysis were obtained by slow evaporation of an ethanol/water (1:1 v/v) solution.

Application

4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.

4-Methylsulphonylphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Methylsulphonylphenylacetic acid Suppliers

Shanghai Taijilin Industrial Co., Ltd.
Tel
021-021-50630626 18964684208
Fax
021-50563898
Email
kate@tajilin.com
Country
China
ProdList
1218
Advantage
58
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
Tel
0513-82104991 18912868322
Fax
QQ1907456386
Email
sales11@btcpharm.com
Country
China
ProdList
1332
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
More
Less

View Lastest Price from 4-Methylsulphonylphenylacetic acid manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
4-(Methylsulfonyl)phenylacetic acid 90536-66-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-07
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Methylsulphonylphenylacetic Acid 90536-66-6
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
Anhui Ruihan Technology Co., Ltd
Product
4-Methylsulphonylphenylacetic acid 90536-66-6
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-11

90536-66-6, 4-Methylsulphonylphenylacetic acidRelated Search:


  • TIMTEC-BB SBB009970
  • 4-MESYLPHENYLACETIC ACID
  • 4-(METHANESULFONYL)PHENYLACETIC ACID
  • 4-METHYLSULPHONYLPHENYLACETIC ACID
  • 4-(METHYLSULFONYL)PHENYLACETIC ACID
  • 4-methylsulfonyl benzeneacetic acid
  • 4-(Methylsulfonyl)PhenylAceticAcid,Etoricoxib
  • 4-Methyl Sulphonile Phenyle Acetic Acid
  • 4-(Methanesulfonyl)phenylaceticacid,97%
  • 4-Methylsulfonylphenylacetic
  • Benzeneacetic acid, 4-(methylsulfonyl)-
  • 4-Mesylbenzeneacetic acid
  • 4-Methylsulphonylphenylacetic acid,95%
  • 4-(Methylsulfonyl)ph
  • 2-(4-methylsulfonylphenyl)acetate
  • Etoricoxib?USP RC B
  • 4-(Carboxymethyl)phenyl methyl sulphone
  • Etoricoxib Related CoMpound B
  • Etoricoxib impurity M
  • 4-(Methylsulfonyl)phenylacetic acid 97%
  • Etoricoxib USP Related Compound B
  • Etoricoxib Intermediate 5
  • Etoricoxib Impurity 28
  • 4-(Methylsulfonyl)phenylaceticAcid&gt
  • OTHER BUILDING BLOCKS
  • 4-(Methylsulfonyl)phenylacetic Acid (Int of Etoricoxib)
  • Etocoxib impurity 2
  • 90536-66-6
  • 35230-23-1
  • C9H10O4S
  • H3CSO2C6H4CH2CO2H
  • Carboxylic acid
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • C9
  • Carbonyl Compounds
  • Carboxylic Acids
  • Building Blocks
  • Carbonyl Compounds