4-Methylsulphonylphenylacetic acid

Product Name: 4-Methylsulphonylphenylacetic acid
CAS No.: 90536-66-6
Chemical Name: 4-Methylsulphonylphenylacetic acid
Synonyms: TIMTEC-BB SBB009970;Etoricoxib?USP RC B;Etocoxib impurity 2;4-(Methylsulfonyl)ph;Etoricoxib impurity M;OTHER BUILDING BLOCKS;Etoricoxib Impurity 28;4-MESYLPHENYLACETIC ACID;4-Mesylbenzeneacetic acid;Etoricoxib Intermediate 5
CBNumber: CB8339797
Molecular Formula: C9H10O4S
Formula Weight: 214.24
MOL File: 90536-66-6.mol

More

Less

4-Methylsulphonylphenylacetic acid Property

Melting point:: 136-140 °C(lit.)
Boiling point:: 324.37°C (rough estimate)
Density: 1.4230 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.90±0.10(Predicted)
color: White to Pale Yellow
Water Solubility: slight
BRN: 2646649
CAS DataBase Reference: 90536-66-6(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29309090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 579114
Product name: 4-(Methylsulfonyl)phenylacetic acid
Purity: 97%
Packaging: 1g
Price: $20
Updated: 2023/06/20

Sigma-Aldrich

Product number: 579114
Product name: 4-(Methylsulfonyl)phenylacetic acid
Purity: 97%
Packaging: 5g
Price: $21
Updated: 2023/06/20

TCI Chemical

Product number: M1899
Product name: 4-(Methylsulfonyl)phenylacetic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: M1899
Product name: 4-(Methylsulfonyl)phenylacetic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $83
Updated: 2024/03/01

Alfa Aesar

Product number: L19504
Product name: 4-(Methylsulfonyl)phenylacetic acid, 97%
Packaging: 5g
Price: $51.65
Updated: 2024/03/01

More

Less

4-Methylsulphonylphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

yellow to beige-brown crystalline powder

Uses

4-(Methylsulfonyl)phenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Preparation

synthesis of 4-(Methylsulfonyl)phenylacetic acid: 1-(4-Methanesulfonyl-phenyl)-ethanone (20 mmol), morpholine (60 mmol) and elemental sulfur (40 mmol) were added in a round-bottom flask and refluxed for 2 h at 398 K. A 3N solution of NaOH (20 ml) was then added, and the reaction mixture refluxed for an additional 30 min. After cooling, the mixture was filtered and the filtrate was acidified with HCl to pH 6. The solution was again filtered off and washed with ethyl acetate. The resulting aqueous fraction was finally acidified with diluted HCl, to yield the pure product as a white solid. Crystals suitable for X-ray analysis were obtained by slow evaporation of an ethanol/water (1:1 v/v) solution.

Application

4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.

4-Methylsulphonylphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Methylsulphonylphenylacetic acid Suppliers

Americas 1 Belgium 1 China 223 Europe 3 France 3 Germany 4 India 52 Japan 4 Poland 2 South Korea 1 Sweden 2 Switzerland 3 United Kingdom 13 United States 29 Global 341

Shanghai Taijilin Industrial Co., Ltd.

Tel: 021-021-50630626 18964684208
Fax: 021-50563898
Email: kate@tajilin.com
Country: China
ProdList: 1230
Advantage: 58

Nantong Xiaochang Pharmaceutical Trading Co., Ltd.

Tel: 0513-82104991 18912868361
Fax: QQ1907456386
Email: sales2@btcpharm.com
Country: China
ProdList: 1329
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

More

Less

View Lastest Price from 4-Methylsulphonylphenylacetic acid manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 4-(Methylsulfonyl)phenylacetic acid 90536-66-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-07

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Methylsulphonylphenylacetic Acid 90536-66-6
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Anhui Ruihan Technology Co., Ltd

Product: 4-Methylsulphonylphenylacetic acid 90536-66-6
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-09-11

90536-66-6, 4-Methylsulphonylphenylacetic acidRelated Search:

2-Methylphenylacetic acid 2-Hydroxyphenylacetic acid 4-Methoxyphenylacetic acid Phenethyl phenylacetate 4-Hydroxyphenylacetic acid DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Methyl 2-methylnicotinate 4-(METHYLSULFONYL)PHENYLACETONITRILE Etoricoxib Impurity 18 Etoricoxib Etoricoxib Impurity 15 (Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime Etoricoxib Impurity 31 Etoricoxib iMpurity 1 Etoricoxib IMpurity Etoricoxib Impurity 7 Etoricoxib impurity 22 Etoricoxib Impurity 9

TIMTEC-BB SBB009970

4-MESYLPHENYLACETIC ACID

4-(METHANESULFONYL)PHENYLACETIC ACID

4-METHYLSULPHONYLPHENYLACETIC ACID

4-(METHYLSULFONYL)PHENYLACETIC ACID

4-methylsulfonyl benzeneacetic acid

4-(Methylsulfonyl)PhenylAceticAcid,Etoricoxib

4-Methyl Sulphonile Phenyle Acetic Acid

4-(Methanesulfonyl)phenylaceticacid,97%

4-Methylsulfonylphenylacetic

Benzeneacetic acid, 4-(methylsulfonyl)-

4-Mesylbenzeneacetic acid

4-Methylsulphonylphenylacetic acid,95%

4-(Methylsulfonyl)ph

2-(4-methylsulfonylphenyl)acetate

Etoricoxib?USP RC B

4-(Carboxymethyl)phenyl methyl sulphone

Etoricoxib Related CoMpound B

Etoricoxib impurity M

4-(Methylsulfonyl)phenylacetic acid 97%

Etoricoxib USP Related Compound B

Etoricoxib Intermediate 5

Etoricoxib Impurity 28

4-(Methylsulfonyl)phenylaceticAcid&gt

OTHER BUILDING BLOCKS

4-(Methylsulfonyl)phenylacetic Acid (Int of Etoricoxib)

Etocoxib impurity 2

90536-66-6

35230-23-1

C9H10O4S

H3CSO2C6H4CH2CO2H

Carboxylic acid

Carboxylic Acids

Chemical Synthesis

Organic Building Blocks

C9

Carbonyl Compounds

Carboxylic Acids

Building Blocks

Carbonyl Compounds