4-Methylsulphonylphenylacetic acid

Product Name: 4-Methylsulphonylphenylacetic acid
CAS No.: 90536-66-6
Chemical Name: 4-Methylsulphonylphenylacetic acid
Synonyms: TIMTEC-BB SBB009970;Etoricoxib?USP RC B;Etocoxib impurity 2;4-(Methylsulfonyl)ph;Etoricoxib impurity M;OTHER BUILDING BLOCKS;Etoricoxib Impurity 28;4-MESYLPHENYLACETIC ACID;4-Mesylbenzeneacetic acid;Etoricoxib Intermediate 5
CBNumber: CB8339797
Molecular Formula: C9H10O4S
Formula Weight: 214.24
MOL File: 90536-66-6.mol

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4-Methylsulphonylphenylacetic acid Property

Melting point:: 136-140 °C(lit.)
Boiling point:: 324.37°C (rough estimate)
Density: 1.4230 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.90±0.10(Predicted)
color: White to Pale Yellow
Water Solubility: slight
BRN: 2646649
CAS DataBase Reference: 90536-66-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 579114
Product name: 4-(Methylsulfonyl)phenylacetic acid
Purity: 97%
Packaging: 1g
Price: $20
Updated: 2023/06/20

Sigma-Aldrich

Product number: 579114
Product name: 4-(Methylsulfonyl)phenylacetic acid
Purity: 97%
Packaging: 5g
Price: $21
Updated: 2023/06/20

TCI Chemical

Product number: M1899
Product name: 4-(Methylsulfonyl)phenylacetic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: M1899
Product name: 4-(Methylsulfonyl)phenylacetic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $83
Updated: 2024/03/01

Alfa Aesar

Product number: L19504
Product name: 4-(Methylsulfonyl)phenylacetic acid, 97%
Packaging: 5g
Price: $51.65
Updated: 2024/03/01

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4-Methylsulphonylphenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

yellow to beige-brown crystalline powder

Uses

4-(Methylsulfonyl)phenylacetic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Preparation

synthesis of 4-(Methylsulfonyl)phenylacetic acid: 1-(4-Methanesulfonyl-phenyl)-ethanone (20 mmol), morpholine (60 mmol) and elemental sulfur (40 mmol) were added in a round-bottom flask and refluxed for 2 h at 398 K. A 3N solution of NaOH (20 ml) was then added, and the reaction mixture refluxed for an additional 30 min. After cooling, the mixture was filtered and the filtrate was acidified with HCl to pH 6. The solution was again filtered off and washed with ethyl acetate. The resulting aqueous fraction was finally acidified with diluted HCl, to yield the pure product as a white solid. Crystals suitable for X-ray analysis were obtained by slow evaporation of an ethanol/water (1:1 v/v) solution.

Application

4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.

4-Methylsulphonylphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methylsulphonylphenylacetic acid Suppliers

Americas 1 Belgium 1 China 224 Europe 3 France 3 Germany 4 India 51 Japan 4 Poland 2 South Korea 1 Sweden 2 Switzerland 3 United Kingdom 13 United States 29 Global 341

Shanghai Taijilin Industrial Co., Ltd.

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J & K SCIENTIFIC LTD.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Adamas Reagent, Ltd.

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View Lastest Price from 4-Methylsulphonylphenylacetic acid manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 4-(Methylsulfonyl)phenylacetic acid 90536-66-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-07

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Methylsulphonylphenylacetic Acid 90536-66-6
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Anhui Ruihan Technology Co., Ltd

Product: 4-Methylsulphonylphenylacetic acid 90536-66-6
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-09-11

90536-66-6, 4-Methylsulphonylphenylacetic acidRelated Search:

2-Methylphenylacetic acid 2-Hydroxyphenylacetic acid 4-Methoxyphenylacetic acid Phenethyl phenylacetate 4-Hydroxyphenylacetic acid DIMETHYL PYRIDINE-2,5-DICARBOXYLATE Methyl 2-methylnicotinate 4-(METHYLSULFONYL)PHENYLACETONITRILE Etoricoxib Impurity 18 Etoricoxib Etoricoxib Impurity 15 (Z)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone oxime Etoricoxib Impurity 31 Etoricoxib iMpurity 1 Etoricoxib IMpurity Etoricoxib Impurity 7 Etoricoxib impurity 22 Etoricoxib Impurity 9

TIMTEC-BB SBB009970

4-MESYLPHENYLACETIC ACID

4-(METHANESULFONYL)PHENYLACETIC ACID

4-METHYLSULPHONYLPHENYLACETIC ACID

4-(METHYLSULFONYL)PHENYLACETIC ACID

4-methylsulfonyl benzeneacetic acid

4-(Methylsulfonyl)PhenylAceticAcid,Etoricoxib

4-Methyl Sulphonile Phenyle Acetic Acid

4-(Methanesulfonyl)phenylaceticacid,97%

4-Methylsulfonylphenylacetic

Benzeneacetic acid, 4-(methylsulfonyl)-

4-Mesylbenzeneacetic acid

4-Methylsulphonylphenylacetic acid,95%

4-(Methylsulfonyl)ph

2-(4-methylsulfonylphenyl)acetate

Etoricoxib?USP RC B

4-(Carboxymethyl)phenyl methyl sulphone

Etoricoxib Related CoMpound B

Etoricoxib impurity M

4-(Methylsulfonyl)phenylacetic acid 97%

Etoricoxib USP Related Compound B

Etoricoxib Intermediate 5

Etoricoxib Impurity 28

4-(Methylsulfonyl)phenylaceticAcid&gt

OTHER BUILDING BLOCKS

4-(Methylsulfonyl)phenylacetic Acid (Int of Etoricoxib)

Etocoxib impurity 2

90536-66-6

35230-23-1

C9H10O4S

H3CSO2C6H4CH2CO2H

Carboxylic acid

Carboxylic Acids

Chemical Synthesis

Organic Building Blocks

C9

Carbonyl Compounds

Carboxylic Acids

Building Blocks

Carbonyl Compounds